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Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

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Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#41

Post by sausagefeet »

gadders wrote: post #39
sausagefeet wrote: post #38

Earlier quoted context omitted.

Well, people are people, and nobody does anything with 100% accuracy. You, trying to put this on the people, is pretty despicable. Context matters a lot. Education matters a lot. Life gets in the way. It sucks. But when you have 8+ billion of people on the planet, expect some percentage of them to do things you think don't make sense to you. Accept it. Telling people to use condoms neither solves the problem, helps t…

>>You, trying to put this on the people, is pretty despicable. To be clear, I am talking about in first world countries where people have more agency and are expected to take responsibility for their own health.

Really? That makes it better? Living in the first world country means you don't make very human mistakes? It means life doesn't get in the way sometimes?

Look, your view seems to be "people in first world countries should be acting how I think they should act, and I just can't imagine myself getting into this situation so that means they can't, and thus I'm going to treat them like they did something wrong".

You don't know the context other people have, so don't judge them.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#42

Post by mort96 »

l5870uoo9y wrote: post #33
mort96 wrote: post #25

Earlier quoted context omitted.

From USAID: > When used correctly and consistently, male condoms are estimated to be 90 percent effective in reducing HIV transmission. They work to a degree, but they're not perfect

They are however effective in preventing transmission of many other STDs that PREP doesn't prevent (and that PREP perhaps indirectly contribute to increasing transmission of including antibiotic resistant STDs).

Yeah, my comment wasn't meant to be anti-condom

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#43

Post by ChrisRR »

Aardwolf wrote: post #3

> and results published Wednesday show it worked nearly as well in men. So not as well? Is there a biological reason for this? Also, is it typical to do such studies on single genders rather than on a mix of humans?

When you're trying to limit the variables on a study, yes. HIV reception between men and women has many differences so it can be better to limit your study and get twice as much data

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#44

Post by n4r9 »

b112 wrote: post #26
mort96 wrote: post #24

Earlier quoted context omitted.

I know from experience that I'm not able to take a vitamin D pill every day in the winter months to combat winter depression. It's actually kinda difficult to build habits like that, and I'd have to remember to bring it with me wherever I may go and stay for a couple of days.

Interesting. Such variance in humans. I find such things inordinately simple. I wake, stretch, urinate, go take my vitamins and drink two glasses of water. A third follows me to my current home office, where I process emails, alerts, whatever may be. I find the best time to triage overnight emails is when I'm not quite awake yet to realise I'm doing it. Less pain that way. The key is it being part of a routine, and t…

How do you ensure that you always have a sufficient stock of vitamins either you, despite being in a different part of the world on a weekly basis?

Do you have kids, if so how do you deal with frequent disruptions to the morning routine? Do you not have days where you just need to get up and go e.g. to catch a flight, get to a meeting, take a kid to school, or because you stayed up late and got drunk, etc... and taking vitamins took a back seat?

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#45

Post by magicalhippo »

gadders wrote: post #40
t-writescode wrote: post #35

Earlier quoted context omitted.

Per https://www.uspharmacist.com/article/medication-adherence-th... > Typically, adherence rates of 80% or more are needed for optimal therapeutic efficacy. However, it is estimated that adherence to chronic medications is around 50%.[3] Adherence rates can go down as time passes after the initial prescription is written, or as barriers emerge or multiply. [3] 3. DiMatteo MR, Giordani PJ, Lepper HS, et al. Patient ad…

People are dumb.

I recently had to take some antibiotics. Three times a day for two weeks.

After about a week I found I started to forget taking them, or getting confused if I had already taken it that morning/afternoon or not.

At the end of my two week stint I had a few pills left, so clearly I had f'ed something up along the way.

Gave me a refreshed perspective on just how difficult it can be to do the seemingly simplest things.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#46

Post by 2Gkashmiri »

t-writescode wrote: post #15
thaumasiotes wrote: post #11

Earlier quoted context omitted.

> Daily pills take a lot of time investment; monthly shots are better That is a matter of opinion. How much time do you think it takes to swallow a pill?

You need to be in the same place, at the same time, every day, and always have them with you, continually. You also need to keep them dry and at room temperature all the time, so no leaving them in your car. Here's another example of a pill that needs to be taken every day, at approximately the same time of day: https://www.plannedparenthood.org/learn/birth-control/birth-... From this article on that pill, > But peop…

https://en.m.wikipedia.org/wiki/Directly_observed_treatment,...

This is already possible by DOTS.

In India it did wonders

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#47

Post by rcxdude »

2Gkashmiri wrote: post #46
t-writescode wrote: post #15

Earlier quoted context omitted.

You need to be in the same place, at the same time, every day, and always have them with you, continually. You also need to keep them dry and at room temperature all the time, so no leaving them in your car. Here's another example of a pill that needs to be taken every day, at approximately the same time of day: https://www.plannedparenthood.org/learn/birth-control/birth-... From this article on that pill, > But peop…

https://en.m.wikipedia.org/wiki/Directly_observed_treatment,... This is already possible by DOTS. In India it did wonders

It's also quite expensive

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#48

Post by raylad »

This treatment does not in fact prevent HIV infection. It prevents infected cells from producing viable virus particles.

Because of this, it seems very likely that if any patient being treated with this drug ever discontinued it, they could develop HIV quickly from cells that were already infected in their body that had been suppressed from producing virus particles but were no longer suppressed.

I was not able to find, in a little searching, any study at all on whether cells infected during treatment survive or are somehow cleared by the immune system or undergo apoptosis. Without this information it seems highly irresponsible to claim that this is a method of preventing HIV infection.

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#49

Post by slashnode »

2Gkashmiri wrote: post #46
t-writescode wrote: post #15

Earlier quoted context omitted.

You need to be in the same place, at the same time, every day, and always have them with you, continually. You also need to keep them dry and at room temperature all the time, so no leaving them in your car. Here's another example of a pill that needs to be taken every day, at approximately the same time of day: https://www.plannedparenthood.org/learn/birth-control/birth-... From this article on that pill, > But peop…

https://en.m.wikipedia.org/wiki/Directly_observed_treatment,... This is already possible by DOTS. In India it did wonders

DOTS is effective for TB because it’s a time-limited treatment (usually 4 months for drug susceptible strains of TB) and is only relevant for treating infected individuals

DOTS wouldn’t be feasible for a prophylactic treatment like this as the number of participants would be huge and the treatment period is indefinite (ie: the patient’s lifespan)

Re: Twice-Yearly HIV Shot Shows 100% Effectiveness in Women

#50

Post by prmoustache »

sausagefeet wrote: post #41
gadders wrote: post #39

Earlier quoted context omitted.

>>You, trying to put this on the people, is pretty despicable. To be clear, I am talking about in first world countries where people have more agency and are expected to take responsibility for their own health.

Really? That makes it better? Living in the first world country means you don't make very human mistakes? It means life doesn't get in the way sometimes? Look, your view seems to be "people in first world countries should be acting how I think they should act, and I just can't imagine myself getting into this situation so that means they can't, and thus I'm going to treat them like they did something wrong". You don'…

Also living in a "first world country" vs "third world country" doesn't mean anything at all. Personal situation, social class and wealth are the key parameters as is financement of specific drug by social security and private insurances.
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