Funny, psilocybin has been largely detrimental to the mental health of everyone I know.
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Psilocybin bests SSRI for major depression in first long-term comparison
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Re: Psilocybin bests SSRI for major depression in first long-term comparison
#42Re: Psilocybin bests SSRI for major depression in first long-term comparison
#43When this topic comes up on HN I'm always sure to mention the book:
"How to Change Your Mind" by Michael Pollan
There's also a Netflix doc series based on the book.
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#44Funny, psilocybin has been largely detrimental to the mental health of everyone I know.
Agreed with a caveat: SSRIs and other antidepressants are far worse.
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#45https://en.wikipedia.org/wiki/Selective_serotonin_reuptake_i... >Post-SSRI sexual dysfunction (PSSD)[62][63] refers to a set of symptoms reported by some people who have taken SSRIs or other serotonin reuptake-inhibiting (SRI) drugs, in which sexual dysfunction symptoms persist for at least three months[64][65][66] after ceasing to take the drug. The status of PSSD as a legitimate and distinct pathology is contentiou…
Can psilocybin restore the mojo, or are you just commenting on the downside of SSRIs?
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#46I think a major criticism of how this study is designed is that it is not truly "blinded". I doubt many of the participants were unsure if they received psilocybin vs escitalopram. That being said, there are a number of studies that suggest this is an effective treatment, so I hope this can become more available to those who need it. However, for treatment resistant depression (especially with a catatonia component),…
The doses of psilocybin being used were so low as to be barely perceptible.
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#47It’s a neat study. I don’t know how you account for the intense placebo effect of a psychedelic experience for six hours though. We know that traditional antidepressants may work through this method already where you feel “different” and fix yourself. Trials with an active placebo often have results very similar to antidepressants. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4172306/ I guess maybe it doesn’t even ma…
For obvious reasons you probably can't put a patient under general anaesthetic before giving them either the placebo or the drug, but I wonder what would happen if you did. Does a patient have to be awake to see the antidepressant effect? How do sedation and sleep differ?
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Re: Psilocybin bests SSRI for major depression in first long-term comparison
#48Earlier quoted context omitted.
Is it something that you still take here and there or was it a time limited therapy ? Congrats on finding a cure for your ailments
Psilocybin tolerance starts building immediately. Even if you microdose (100 mg), it will stop being effective after 3-4 days.
100mg psilocybin is several times a heroic dose, but 100ug is far below a microdose. Do you mean 100mg of dried mushrooms?
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#49> "Psychiatrists really focus on negative symptoms of depression. So, if you are not sad anymore, if your sleep or appetite is not impaired, they think you're better. But if you look at what patients define as important, they say it's the degree in which their life is meaningful, in which they can connect with people around them, in which they can function in everyday life," Barba said. A more wholistic approach to h…
> I often hear people talk about the risks of psychedelics, which are to be considered, but what’s the risk of doing nothing or withholding the best treatment?
The risk is to make things worse.
And I know that I am preaching to people that are of the opinion that they know better than the FDA, scientists and doctors and are all for self-medicating based off of the echo chamber here and a few cherry-picked, limited and flawed by default (like in the case of this one) studies on the first page of Google.
Re: Psilocybin bests SSRI for major depression in first long-term comparison
#50Earlier quoted context omitted.
Is it something that you still take here and there or was it a time limited therapy ? Congrats on finding a cure for your ailments
Psilocybin tolerance starts building immediately. Even if you microdose (100 mg), it will stop being effective after 3-4 days.
Tolerance also wanes quickly. In 3 days of abstaining, you’re nearly entirely back to baseline tolerance. In 2 weeks you’re entirely back to baseline.