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The brain has its own microbiome

newscientist.com

41–50 of 53 posts

Re: The brain has its own microbiome

#41

I have a genetic partial immunodeficiency (PNP Deficiency) and I constantly get fungal infections. Living in warm, humid climates is a challenge for me. Reading just the beginning of that article "she experienced chronic pain, digestive problems and a cardiac arrhythmia", well, that is my life. I constantly have minor aspergillosis, and I have some lung nodules from some past fungal infections as well. Keeping the mi…

So, something is weird here, just want to invade this thread and ask HN if there should be a change. I literally have no idea why someone would downvote this comment. But someone did. This does not bother my ego, it bothers my sensibilities. So, maybe we should not allow downvotes unless someone comments on why they thing the comment is negative. No need to do this for upvotes because there is no need to comment on t…

From my experience with making comments connecting guy problems to other illnesses, I think the issue is HN hates anecdotal reports and especially when it contradicts "science".

I put that in quotes because we barely study the microbiome as the root cause for many issues (incredibly difficult to isolate variables) and there's constantly reports of academic malfeasance. As time goes on we also see the microbiome is responsible in things like Alzheimer's and Parkinson's. But after every new discovery if you try to insinuate there's others, people will say "no no, it's just there's nothing else has to do with that"... intil the next discovery that was only found because they decided to actually invest money into researching it.

Re: The brain has its own microbiome

#43

Earlier quoted context omitted.

Or maybe your reaction to this downvote is the problem?

Down voting parent because it is entirely unproductive -- combative, with no attempt to explain itself.

Ha! Thanks! Nice! So I want to add as well, why just can I not down vote someone who makes a comment under mine but I can still up vote them? Why does my down vote not count when in this case?

To me it seems to make HN favor bias instead of new ideas (which may be right or wrong, but without

Re: The brain has its own microbiome

#44

I mentioned Adam Savage's "Scariest [Podcast] Episode Yet" in a different context the other day[0] in which I remember Joe DeRisi[1] saying something along the lines of brain & spinal fluid being "absolutely pristine" when it comes to the presence/absence of a microbiome (in healthy individuals) and that it'd be real problem if there were one. I'm just a layman but can anyone ELI5 how this can be squared with the OP,…

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Re: The brain has its own microbiome

#45
post #7
post #3

Earlier quoted context omitted.

We can take it one step further: There are microbes everywhere in your body, they matter and they do things. When you take them away or fuck with them too much, weird things start happening. It is I think not a particularly surprising take. But then often it can be valuable to have things that are kind of obvious codified into a paper of some sort so that we no longer have to rely on "but isn't that obvious?" and can…

Is there any evidence (yet?) of an autoimmune disease caused by the immune system accidentally attacking part of the micro-biome?

Yes, as far as I know. I thought this was a nice overview: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6300652/

Re: The brain has its own microbiome

#46

Surprised as how such basic stuff gets "discovered" now and then. For all the toot of science, how come it took us that long to realise such a basic (in appearance at least I'm sure) fact ?

I'm sure there are many other things still unknown and many things known but may change. Science is about discovery and many new discoveries are made even basic but also complex discoveries. Information known can change when new information is discovered. Science is not carved in stone it's not faith and corrections, updates are welcome part of discovery.

Re: The brain has its own microbiome

#47
post #23

Next will we find that there is an exchange of microbes between the brain and gut?

Of course. Gut microbes to blood via leaky gut, small enough blood microbes to brain via BBB.

So-called " leaky gut" is hogwash pushed by quacks. It's what influencers push on TikTok or at least their interpretation of it.

https://www.mcgill.ca/oss/article/medical-critical-thinking/...

Re: The brain has its own microbiome

#48
post #23

Earlier quoted context omitted.

Of course. Gut microbes to blood via leaky gut, small enough blood microbes to brain via BBB.

So-called " leaky gut" is hogwash pushed by quacks. It's what influencers push on TikTok or at least their interpretation of it. https://www.mcgill.ca/oss/article/medical-critical-thinking/...

Sure, leaky gut as a diagnosis is a misapplication for the science. What is real is varying permeability of the intestinal lining in all humans.

Re: The brain has its own microbiome

#49
post #9
post #6

Earlier quoted context omitted.

The most foundational science is pretty obvious after all. We all know that apples fall from trees and that banging 2 rocks together makes sparks.

It's obvious from apples falling from trees that gravity is actually the curvature of spacetime?

I think maybe “foundation” was the wrong word.

Maybe origins?

My point was that the basic ideas that have been studied and refined over centuries were simple.

Re: The brain has its own microbiome

#50
post #23

Earlier quoted context omitted.

Of course. Gut microbes to blood via leaky gut, small enough blood microbes to brain via BBB.

So-called " leaky gut" is hogwash pushed by quacks. It's what influencers push on TikTok or at least their interpretation of it. https://www.mcgill.ca/oss/article/medical-critical-thinking/...

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