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It took my savings and 14 years but I’m about to beat arthritis

thetimes.com

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Re: It took my savings and 14 years but I’m about to beat arthritis

#41

Post by adgjlsfhk1 »

Noumenon72 wrote: post #27
kbos87 wrote: post #22

Earlier quoted context omitted.

Anyone who takes a drug every day has had this thought and quickly moved past this narrow point of view. We all want to live long, healthy lives, and whether we like to admit it or not, the human body isn't built to match our modern expectations for longevity. If you plan to live a long and comfortable life, taking multiple drugs every day is in your future. For some of us it comes sooner than it does for others.

According to the first page of Google, > Nearly nine in ten (89%) adults 65 and older report they are currently taking any prescription medicine. This compares to three-fourths of 50-64 year olds who report taking prescription drugs, half (51%) of 30-49 year olds, and four in ten (38%) 18-29 year olds. I, of course, am built different.

It would be interesting to see this broken down by gender since birth control likely accounts for a substantial portion of the 18-49 year olds.

Re: It took my savings and 14 years but I’m about to beat arthritis

#42

Post by ramraj07 »

brianleb wrote: post #20

My only commentary would be that these results do not read like clinical success, but rather something suggesting they should move on to phase III clinical trials. This is the only publication I found in a quick search: https://pubmed.ncbi.nlm.nih.gov/37976118/ >> Abstract Objectives: Nerve growth factor β (β-NGF) is a protein which is important to the development of neurons particularly those involved in the transmi…

It’s phase 2, not peer review published yet but results are out -https://www.morningstar.com/news/globe-newswire/1000985090/l...

Sounds significant. Phase II is typically not enough to tell if a drug is good because most drugs aren’t that effective compared to current standard of care- you need the large numbers of phase iii to see the real difference. But looks like this drug shows a marked improvement in phase ii itself so it’s actually quite impressive. Last time I read such a story was for imatinib. Expecting good things from this.

Re: It took my savings and 14 years but I’m about to beat arthritis

#44

Post by Cerium »

ein0p wrote: post #43

> The drug is based on a molecule he discovered while working at Pfizer I can see Pfizer lawyers salivating uncontrollably after reading that phrase. Extremely unwise of him to mention this.

Until they read the next part:

> On leaving the company, he acquired the intellectual property [IP] rights from his former employer

Re: It took my savings and 14 years but I’m about to beat arthritis

#46

Post by VintageCool »

Cerium wrote: post #44
ein0p wrote: post #43

> The drug is based on a molecule he discovered while working at Pfizer I can see Pfizer lawyers salivating uncontrollably after reading that phrase. Extremely unwise of him to mention this.

Until they read the next part: > On leaving the company, he acquired the intellectual property [IP] rights from his former employer

And Pfizer is an investor in his company.

Re: It took my savings and 14 years but I’m about to beat arthritis

#47

Post by aszantu »

purple-leafy wrote: post #21

Paywalled. How legitimate is this? As a young sufferer

been on an elimination diet for a while, because if I'm not, I get depression and suicidal ideation.

I don't have a diagnosis for arthritis, but I'm testing around a lot and maybe this info helps you in your journey:

I make gelatine from pig's feet occasionally, when I make it with just salt and some lemon or vinegar, I don't have problems.

Last time I thought, maybe try bell pepper, haven't tried for a while and I seem to do okay with capsaicin. Boy was I wrong, within a week I got horrible joint pain in the feet.

Bell peppers are seemingly high in lectin and other phyto-nutrients.

I recently found on hacker news, that I can neutralize oxolates with a pro-biotic - will try that for lectins next. Have to prepare the gut with L-Glutamine and Silicea.

God's speed!

Edit: Between ingestion and symptoms, it takes about 3-4 days

Re: It took my savings and 14 years but I’m about to beat arthritis

#48

Post by sargun »

fnord77 wrote: post #17

They had very good, robust Phase II results. Thinks can go wrong in Phase III. Relyvrio (HIV vaccine) did well in P2 but flopped on P3. Cancer drug xevinapant failed in P3 after Merck executives were reassuring analysts that the failure of a phase 3 trial of xevinapant was “unlikely.”

Relyvrio was ALS drug.

I don't think any HIV vaccines have gotten to phase III yet.

Re: It took my savings and 14 years but I’m about to beat arthritis

#49

Post by deamanto »

brianleb wrote: post #20

My only commentary would be that these results do not read like clinical success, but rather something suggesting they should move on to phase III clinical trials. This is the only publication I found in a quick search: https://pubmed.ncbi.nlm.nih.gov/37976118/ >> Abstract Objectives: Nerve growth factor β (β-NGF) is a protein which is important to the development of neurons particularly those involved in the transmi…

Interesting - this looks like Beransa[1] (Librela) which is a monthly injection for canines that have osteoarthritis. My dog did not have any noticeable changes to pain after using this for 2 months so I've decided to take him off of it.

[1] - https://en.wikipedia.org/wiki/Bedinvetmab

Re: It took my savings and 14 years but I’m about to beat arthritis

#50

Post by gamblor956 »

The drug is based on a molecule he discovered while working at Pfizer

On leaving the company, he acquired the intellectual property [IP] rights from his former employer

A lot of people don't do this when they leave or are terminated. It doesn't usually succeed, but it's always worth at least making the attempt. (In this case, Pfizer gave him the IP rights to the molecule he discovered in exchange for a portion of his company.)

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