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Psilocybin desynchronizes the human brain

nature.com

41–50 of 276 posts

Re: Psilocybin desynchronizes the human brain

#42
post #39

Earlier quoted context omitted.

It can also induce a psychological break and/or acute schizophrenia and/or lasting distortions of perception, so maybe cool it with the unwarranted medical advice

So can plenty of prescription drugs. I suspect you wouldn't criticize someone for suggesting, "unwarranted", that someone tries anti-depressants or any number of potentially dangerous anxiolytics. Cool it with your moral authority.

I would absolutely give them flak because you are exactly right about these drugs. If certain medications/"medications" can help people in any way, that's awesome! But we can't treat them like harmless fun candy or like a productivity/meditation hack.

Re: Psilocybin desynchronizes the human brain

#43

Earlier quoted context omitted.

Around 1% of people have schizophrenia. This holds over a lifetime - there's a structural, unavoidable component to the person's neural wiring or physiology that will result in a schizophrenic break. Prior to the break, they may seem more or less normal, but after, they will experience deficits in cognition and perception, and may have significant barriers to living a normal life. Schizophrenics, as a rule, will have…

As I said in another post, the mental illness is not the issue here, the immediate access to a gun while blasted on shrooms is.

At least 42% of Americans live in a household with a gun so it isn't particularly useful to write off the anecdote.

Re: Psilocybin desynchronizes the human brain

#44

Earlier quoted context omitted.

Around 1% of people have schizophrenia. This holds over a lifetime - there's a structural, unavoidable component to the person's neural wiring or physiology that will result in a schizophrenic break. Prior to the break, they may seem more or less normal, but after, they will experience deficits in cognition and perception, and may have significant barriers to living a normal life. Schizophrenics, as a rule, will have…

As I said in another post, the mental illness is not the issue here, the immediate access to a gun while blasted on shrooms is.

Not really, here in Amsterdam we had tourist jump of bridges and buildings on shrooms.

Re: Psilocybin desynchronizes the human brain

#45
post #12

While the analogies are often useful, everyone reading HN comments should be very aware and very skeptical of just how often computer/tech people rely on computer/tech analogies to understand things that are fundamentally not computers/tech. It is very very easy for smart people with functionally specific jobs/hobbies/ways of thinking to see all reality through that narrow window. It often leads to important details…

Feeling "it is just a feeling" is also just a feeling.

Not in the sense I meant. The “enlightenment” confidence and awe-struck assuredness is the feeling and it comes from deep inside.

Recognizing that confidence and assuredness are not knowledge is not quite the same as those feelings themselves. Though I do recognize this is sort of recursive and cyclical and ultimately there’s nothing but some type of faith to build everything on, including doubt/skepticism.

Re: Psilocybin desynchronizes the human brain

#46

[flagged]

It can also induce a psychological break and/or acute schizophrenia and/or lasting distortions of perception, so maybe cool it with the unwarranted medical advice

We are going to need to know the rate of this happening. And who said it happens?

Re: Psilocybin desynchronizes the human brain

#47
post #39

Earlier quoted context omitted.

It can also induce a psychological break and/or acute schizophrenia and/or lasting distortions of perception, so maybe cool it with the unwarranted medical advice

So can plenty of prescription drugs. I suspect you wouldn't criticize someone for suggesting, "unwarranted", that someone tries anti-depressants or any number of potentially dangerous anxiolytics. Cool it with your moral authority.

Telling everyone to do a dose of anti-depressants is just the same. Not a great idea.

Re: Psilocybin desynchronizes the human brain

#48
post #12

While the analogies are often useful, everyone reading HN comments should be very aware and very skeptical of just how often computer/tech people rely on computer/tech analogies to understand things that are fundamentally not computers/tech. It is very very easy for smart people with functionally specific jobs/hobbies/ways of thinking to see all reality through that narrow window. It often leads to important details…

There are ways things can be computers that don't require the typical setup of a von Neumann architecture. Psilocybin taught me that. My education and subsequent studies confirmed that.

Re: Psilocybin desynchronizes the human brain

#50

>Healthy adults were tracked before, during and for 3 weeks after high-dose psilocybin (25 mg) and methylphenidate (40 mg), and brought back for an additional psilocybin dose 6–12 months later. Not simultaneously I hope.. that sounds like it would be a rough ride

No, they were separate dosages to compare FC effects.
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