This is Jake Seliger ('jseliger)'s partner, if you're wondering.
mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
41–50 of 111 posts
Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#42Earlier quoted context omitted.
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> Anti-vaxxers predate Covid. Every idea exists, the question is how prevalent. I knew many people who did not take it due to mandates, or took it and resisted the mandates (never showed card etc). In retrospect the alarmism you’re still using was totally wrong. I believe the official story now is that Covid vaccines mildy reduce symptoms and more effectively reduce transmission?
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Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#43> RNA is fragile. So, like in the COVID mRNA vaccines, these instructions can be delivered in a protective fatty bubble called a “lipid nanoparticle.” Think of it like a balloon made of fatty acids, with the instructions nestled inside. Once injected, these lipid nanoparticles take the mRNA instructions into cells, where the fatty bubble degrades, mRNA instructions are released, and the cell’s machinery start to prod…
Everything you said sounds interesting, but my experience, as a scientist in a different field, is that media focused for regular non-expert people simply isn't going to capture those kinds of things. You need to find recent papers, review articles or maybe textbooks to get that kind of information, basically its going to be in documents targeted at experts in this field not lay people.
You are correct, and the problem with these articles is that they sound too much like a sales pitch and less like a responsible general-public divulgation article.
She may not go in detail about the items aforementioned, but she doesn't even mention once that the technology might have have possible dangers, and that one must exercise caution in its evaluation. The article its all about the potential benefits of the technology, without warning the public about its potential dangers.
She even mentions that "the FDA is so painfully slow, and so indifferent to human suffering. It takes, on average, eight years to get a new drug through clinical trials."
Yeah, those pesky thorough clinical trials, they are a hurdle on the return on investment.
Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#44Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#45It's a shame mRNA vaccines don't work like traditional vaccines. The problem with mRNA vaccines is that they cause the immune system to attack healthy cells throughout the body, when the injected mRNA causes those cells to emit foreign proteins. For most parts of the body, that's fine, because it's okay to gain some muscle scar tissue in the arm. But muscle scar tissue in the heart will measurably shorten one's life…
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Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#46Earlier quoted context omitted.
Making the immune system target tissue produced by the body, even a cancerous growth, is risky business.
The immune system does this all the time. They're called natural killer cells (NK Cells) and they regularly target cells that have become cancerous or infected.
Well yes, NK cells do that when we're infected with a malignant infection.
For the last hundred years, or so, vaccines have been non-malignant, so we've never had to question such things.
However, mRNA vaccines are an entirely novel class of technology, so it's appropriate for us question:
a) how long mRNA vaccines persist in the body? b) how discriminating are mRNA vaccines in which cells they impact? c) if any testing was done on the side effects of accidental intravenuous injection of mRNA vaccines? (given that there are plenty of blood vessels in muscle tissue) d) if any longitudinal studies have been done on mRNA vaccination of humans? e) if any comprehensive studies have been done on pregnant or nursing women injected with mRNA vaccines, and the impact on their infants?
Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#47Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#48> RNA is fragile. So, like in the COVID mRNA vaccines, these instructions can be delivered in a protective fatty bubble called a “lipid nanoparticle.” Think of it like a balloon made of fatty acids, with the instructions nestled inside. Once injected, these lipid nanoparticles take the mRNA instructions into cells, where the fatty bubble degrades, mRNA instructions are released, and the cell’s machinery start to prod…
The mRNA vaccine mostly stays near the site of injection: your arm. This is why your arm mostly aches, and the rest of your body not so much. A bunch of cells there will die, because your immune system much prefers an innocent cell dead than a infected cell continuing to multiply. But you have plenty of cells. Really quite a lot. So it is entirely worth it.
We can try to optimize how much protein cells will make from the mRNA. The goal is "as much as possible, for as long as possible", but mRNA is not meant to be long lived. And foreign mRNA trying to make its way into cells would be destroyed very quickly without trickery (like the nanoparticle and the pseudouridine).
But either way, medicine works just the same (a surprising amount of the time!) in the cases where the precise details and mechanisms haven't been elucidated yet. If it works empirically, the details are just details.
Re: mRNA vaccines: let's eradicate herpes, cure cancer, and be sick a whole lot less
#49> RNA is fragile. So, like in the COVID mRNA vaccines, these instructions can be delivered in a protective fatty bubble called a “lipid nanoparticle.” Think of it like a balloon made of fatty acids, with the instructions nestled inside. Once injected, these lipid nanoparticles take the mRNA instructions into cells, where the fatty bubble degrades, mRNA instructions are released, and the cell’s machinery start to prod…
Similarly, my question is if we trick random cells around the body into producing these spike proteins, and they presumably don't stop for a while (no idea on how long), does this not also create an undo burdon on the immune system until the cells artificially producing the protein die? And if there's loose RNA floating around, after these cells die can another cell _also_ start reproducing the protein?
I think the idea is that the RNA doesn't last long. It's quite fragile. You might get fragments of it though, but not enough to print out the whole protein.