Earlier quoted context omitted.
> not a big gaping structural hole. It's an exit door opening, not some random part of the fuselage developing a potentially structure-compromising hole...
Bad wording on my part since I implied but didn't state the alternative. In my mind, the alternative scenario that would create a depressurization event would be a small hole or a hole that is not visible from the passenger compartment. I.e., a hole from which a passenger or attendant could not exit the plane.
I suppose if the small hole had existed since before takeoff, you could avoid catastrophic damage as the aircraft will not be pressurized at all. I wouldn't call it a depressurization event, though.