Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Oral cancer drug kills 100% of tumors in vitro and in animal models

twitter.com

Post reply on HN
Print view View original

41–50 of 108 posts

Re: Oral cancer drug kills 100% of tumors in vitro and in animal models

#41

Post by plibither8 »

isoprophlex wrote: post #12

https://en.m.wikipedia.org/wiki/AOH1996 Look at that molecular structure. Incredible. Two amide bonds, a completely unremarkable aryl ether and an unsubstituted naphthalene ring system. No fussy weird metals or bonds that need pampering, no chiral carbon atom in sight. You could probably pay someone a very modest amount of money to end up with kilograms of this stuff, and it would probably not degrade at all under am…

> Look at that molecular structure. Incredible.

I first thought it was a joke because of the two "HN" bonds hah, pardon me.

Re: Oral cancer drug kills 100% of tumors in vitro and in animal models

#42

Post by emn13 »

malfist wrote: post #16

Temper expectations, in vitro tests are very different than in vivo tests. Arsenic also kills 100% of tumors in vitro. In vitro doesn't answers the question of "can this drug be taken safely" nor "can this drug be delivered to the cancer cells"

Sure, and most miracle drugs don't pan out. Yet there is some reason to at least hope this is a little better than arsenic - it didn't kill the mice nor dogs, and there are various plausible sounding claims about toxicity made (to a non-expert, I just googled the various methods and showed the paper to cancer-researching friend that didn't immediately cry foul).

I mean, the track record of such drugs still suggests it'll likely not live up to the hype of the title here, but that's the point of further research, which does appear to be happening. It's quite likely there's some unforeseen limitation, but hey, we can always hope.

Re: Oral cancer drug kills 100% of tumors in vitro and in animal models

#43

Post by [deleted] »

teruakohatu wrote: post #37
isoprophlex wrote: post #12

https://en.m.wikipedia.org/wiki/AOH1996 Look at that molecular structure. Incredible. Two amide bonds, a completely unremarkable aryl ether and an unsubstituted naphthalene ring system. No fussy weird metals or bonds that need pampering, no chiral carbon atom in sight. You could probably pay someone a very modest amount of money to end up with kilograms of this stuff, and it would probably not degrade at all under am…

Can you explain to a layman why works to kill tumors and not healthy cells?

[deleted]

Re: Oral cancer drug kills 100% of tumors in vitro and in animal models

#44

Post by metadat »

Related recent discussions:

A New Mode of Cancer Treatment - https://news.ycombinator.com/item?id=36982813 - Aug 2023 (205 comments)

New targeted chemotherapy able to kill all solid tumors in preclinical research - https://news.ycombinator.com/item?id=36978199 - Aug 2023 (32 comments)

'Cancer-killing pill' is now being tested on humans - https://news.ycombinator.com/item?id=36969500 - Aug 2023 (33 comments)

Cancer pill AOH1996 shows promise in annihilating all solid tumours - https://news.ycombinator.com/item?id=36960895 - Aug 2023 (19 comments)

Cancer pill AOH1996 shows promise in annihilating all solid tumours - https://news.ycombinator.com/item?id=36960292 - Aug 2023 (16 comments)

Edit: @dang: Thanks, incorporated your addition.

Re: Oral cancer drug kills 100% of tumors in vitro and in animal models

#46

Post by amluto »

SketchySeaBeast wrote: post #19
malfist wrote: post #16

Temper expectations, in vitro tests are very different than in vivo tests. Arsenic also kills 100% of tumors in vitro. In vitro doesn't answers the question of "can this drug be taken safely" nor "can this drug be delivered to the cancer cells"

Obligatory xkcd https://xkcd.com/1217/

I admit I’ve never been convinced that a handgun would be especially effective. I would certainly not expect a bullet to make a dish full of airborne pathogenic bacteria or viruses safe.

Re: Oral cancer drug kills 100% of tumors in vitro and in animal models

#47

Post by danielvaughn »

zer8k wrote: post #36

Given the importance of this medication and it's promising initial data I have no idea why it's not given "warp speed" clearance. We cleared mRNA technology almost overnight in response to the pandemic. I feel like society as a whole has collective amnesia on how this happened. A relatively novel strategy to rapidly produce a vaccine in response to a pandemic was trialed essentially on a global scale. The phase 1/2/3…

Agreed; it should at least match the energy devoted to superconductivity.

Re: Oral cancer drug kills 100% of tumors in vitro and in animal models

#48

Post by jokowueu »

syntaxing wrote: post #18
jokowueu wrote: post #13

Earlier quoted context omitted.

Tbh Since it's a small molecule you can just hire a lab to make a custom synth , I've seen it done a few times,

So…what kind of labs can you hire to make this and how much would it cost?

It depends on the difficulty of making it and the amount required.

https://pastebin.com/0pyuDBX1

Re: Oral cancer drug kills 100% of tumors in vitro and in animal models

#49

Post by kybernetikos »

isoprophlex wrote: post #12

https://en.m.wikipedia.org/wiki/AOH1996 Look at that molecular structure. Incredible. Two amide bonds, a completely unremarkable aryl ether and an unsubstituted naphthalene ring system. No fussy weird metals or bonds that need pampering, no chiral carbon atom in sight. You could probably pay someone a very modest amount of money to end up with kilograms of this stuff, and it would probably not degrade at all under am…

Derek Lowe had a similar take:

"AOH1996 is a very unremarkable-looking molecule - to be honest, it looks like the sort of stuff that you used to see in old combinatorial chemistry libraries in the late 90s and early 2000s, a couple of aryl-rich groups strung together with amide bonds."

https://www.science.org/content/blog-post/new-mode-cancer-tr...

Re: Oral cancer drug kills 100% of tumors in vitro and in animal models

#50

Post by janejeon »

Terr_ wrote: post #27
isoprophlex wrote: post #12

https://en.m.wikipedia.org/wiki/AOH1996 Look at that molecular structure. Incredible. Two amide bonds, a completely unremarkable aryl ether and an unsubstituted naphthalene ring system. No fussy weird metals or bonds that need pampering, no chiral carbon atom in sight. You could probably pay someone a very modest amount of money to end up with kilograms of this stuff, and it would probably not degrade at all under am…

> Look at that molecular structure. Incredible. Two amide bonds, a completely unremarkable aryl ether and an unsubstituted naphthalene ring system. Something about this delivery reminds of the business-card scene from Psycho [0]. > Look at that subtle off-white coloring, the tasteful thickness of it--Oh my God, it even has a watermark..." [0] https://www.youtube.com/watch?v=cISYzA36-ZY

Now let's see Paul Allen's molecule.
Post reply on HN