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Fentanyl vaccine tested in rats

uh.edu

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Re: Fentanyl vaccine tested in rats

#41

Post by DiabloD3 »

eddsh1994 wrote: post #26
DiabloD3 wrote: post #6

Earlier quoted context omitted.

Let's go another way with this: You are extremely unlikely to ever come across a fentanyl user, even if you work for law enforcement, even if you're a LEO in a major metro. 10x people died of heart attacks than any opioid, not only fentenyl, over the past few years. Almost as many people died of cancer as heart attacks, and half as many people died of COVID as cancer. Obviously, you can't equate research with other r…

Fentanyl is the leading cause of death for those aged 18 to 45 in the US. Seems pretty important to me. We can also look at the things you suggested, it's not like there's an Obesity OR Fentanyl choice here.

> it's not like there's an Obesity OR Fentanyl choice here

Thats kind of my point. If they managed to make a working vaccine, good on them. It doesn't necessarily take away from efforts into other things, as two parents above me were casually implying.

Re: Fentanyl vaccine tested in rats

#44

Post by slowking2 »

pazimzadeh wrote: post #21
shadowgovt wrote: post #9

This is a good time to remind people that https://twitter.com/justsaysinrats exists for a reason. ... and, indeed, the uh.edu article only tangentially indicates that the actual study ( https://www.mdpi.com/1999-4923/14/11/2290/htm ) has only been conducted in rats at this time. Interesting, but since it's brain chemistry we should be wary of getting too excited about the likelihood that this chemical pathway works s…

Isn't the whole point of doing it in rats that it's way more similar to humans than say Drosophila flies? Somewhat related: has the result from the Rat Park experiment been debunked or shown not to apply in humans? https://en.wikipedia.org/wiki/Rat_Park

The link you posted says that the original rat park researcher's own graduate student was unable to replicate the original experiment when he tried reducing the confounds. That seems like the most favorable possible situation for a replication to me. It also says that one confound was that morphine consumption wasn't measured in the same way between conditions in the original experiment. That seems pretty bad to me. Linked article also mentions that other researchers have had trouble replicating the results fully.

Rat park doesn't consistently apply to rats, so why should its results be considered particularly informative about humans?

Has someone done a much better study on rats since then? Significantly larger N, always taking measurements the same way across conditions, genetics carefully controlled or at least measured? I'm not an animal behavior researcher, so I'm sure there could be other things important to handle.

Rats are certainly more similar to humans that flies are, but that doesn't mean any particular study is informative about humans.

Re: Fentanyl vaccine tested in rats

#45

Post by denimnerd42 »

rcpt wrote: post #40
denimnerd42 wrote: post #15

Earlier quoted context omitted.

Yes people take fentanyl intentionally. The real heroin, the real opioid pills, and other forms of opioids have mostly dried up. Now we get fentanyl and fentanyl analogs, and other potent synthetic opioids that aren't well tracked. The reason is that it's extremely potent so it's easier to smuggle from China, Mexico, wherever it's being made. So now you get "pressies" [homemade pressed pills] which is diluted fentany…

Would this be solved by legalizing and regulating opiates?

You would think. But FDA is going opposite direction making legal opiates even harder to get by putting pressure on doctors.

Re: Fentanyl vaccine tested in rats

#46

Post by factsarelolz »

Ekaros wrote: post #39
ARandomerDude wrote: post #13

Earlier quoted context omitted.

And how do you propose we get all the users vaccinated with the fentanyl jab? Another round of mass vaccinations? Make all the kids in school do it? Forced vaccinations for anyone in jail or rehab? Honestly, all of those seem like bad ideas.

Didn't we already do it? Ban people from working if they don't take it, maybe take away any benefits too. Don't allow them to public places?

> Ban people from working if they don't take it, maybe take away any benefits too. Don't allow them to public places?

Over a one's own choice to not have a medical procedure?

Should we do the same to those whom have abortions?

Who gets to make a choice on what medical procedures a population should have? Why is it not the individuals decision?

Re: Fentanyl vaccine tested in rats

#47

Post by cinntaile »

chitowneats wrote: post #43
lazyeye wrote: post #42

[flagged]

No, it's a miracle painkiller used by doctors all over the world. Just like oxycontin it has a legitimate medical use.

Please don't do this, it's very tiring to discuss like this. He's obviously talking about illegal fentanyl use.

Re: Fentanyl vaccine tested in rats

#48

Post by klyrs »

actionfromafar wrote: post #30
version_five wrote: post #22

Earlier quoted context omitted.

> Something like this happened in neuromancer. Right, and Case bought betaphenethylamine instead of speed which was way harsher. That's exactly what is going to happen, some more potent drug that escapes the vaccine is going to get more popular. It's a bandaid solution that ignores the root cause (drug prohibition)

Wait, what? Selling fentanyl as candy in every street corner shop is going to fix this?

There is a broad gulf between selling something like candy and criminalizing its possession. You need to be of-age to buy beer. Sudafed is sold OTC but with strict limits. You need a prescription to get many pharmaceuticals.

Re: Fentanyl vaccine tested in rats

#49

Post by freedomben »

sandermvanvliet wrote: post #33
shadowtree wrote: post #32

Pray you then never get cancer or other nasty shit that requires proper painkillers.

The article mentions that it’s specifically targeted at fentanyl and doesn’t interact with other opioids such as morphine

Fentanyl is preferred for cancer patients and end-of-life patients for a reason. Morphine is difficult to administer efficaciously at those levels of suffering, and has some very undesirable side effects (so I've been told. IANA Anesthesiologist).

Re: Fentanyl vaccine tested in rats

#50

Post by factsarelolz »

kjkjadksj wrote: post #23
D13Fd wrote: post #8

Earlier quoted context omitted.

Yeah but my understanding is that most of the overdosing are from people seeking something else. In some cases it’s akin to a contamination problem.

We are at the point in the fentanyl epidemic where most users are specifically seeking out fentanyl or fentanyl laced drugs.

Because fentanyl is way cheaper by itself. Why mix in more expensive drugs? The issue is China, full stop.
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