Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Possible impact of functional active gpcr-autoantibodies in long Covid

iovs.arvojournals.org

Post reply on HN
Print view View original

41–50 of 53 posts

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#41

Post by languageserver »

cjbgkagh wrote: post #36
kens wrote: post #23

The title here ("100% of Long Covid patients have GPCR-autoantibodies") is editorialized, making this sound interesting. The actual title is "Possible Impact of functional active GPCR-autoantibodies on retinal microcirculation in Long-COVID." The study looked at 76 long covid patients with no control group, so you can't make a general conclusion from it. This post is a waste of time unless you're interested in obscur…

I couldn't tell from the abstract (is there a link I missed), but I suspect that the test for GPCR-autoantibodies has a baseline (e.g. to test positive you must be 2-sd above the mean). From that if all 76 test positive you can know without a control group that that is otherwise very unlikely and a strong signal of correlation.

yea, these people have had covid.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#42

Post by yunohn »

robonerd wrote: post #30
evandijk70 wrote: post #5

Earlier quoted context omitted.

Another question: how common are GPCR-antibodies in non-covid patients?

Very common, no doubt. Targeting GPCRs is a very wide net, GPCRs are a huge superfamily of proteins. > GPCRs are an important drug target and approximately 34%[6] of all Food and Drug Administration (FDA) approved drugs target 108 members of this family. The global sales volume for these drugs is estimated to be 180 billion US dollars as of 2018.[6] It is estimated that GPCRs are targets for about 50% of drugs curren…

I’m not a medical expert, but antibodies and auto-antibodies are not the same thing.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#43

Post by robonerd »

yunohn wrote: post #42
robonerd wrote: post #30

Earlier quoted context omitted.

Very common, no doubt. Targeting GPCRs is a very wide net, GPCRs are a huge superfamily of proteins. > GPCRs are an important drug target and approximately 34%[6] of all Food and Drug Administration (FDA) approved drugs target 108 members of this family. The global sales volume for these drugs is estimated to be 180 billion US dollars as of 2018.[6] It is estimated that GPCRs are targets for about 50% of drugs curren…

I’m not a medical expert, but antibodies and auto-antibodies are not the same thing.

An auto-antibody is any antibody targeting your own proteins. My point is GPCR is not a protein, but a huge family of proteins that are broadly relevant to a huge range of conditions.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#44

Post by kennywinker »

IMTDb wrote: post #39
kennywinker wrote: post #24

Earlier quoted context omitted.

I think at this point diagnosing long covid necessarily involves trusting patients. If you had no chronic illness symptoms you were aware of, and then get covid, and then have chronic illness symptoms - that's long covid. Until we understand what it is better, there's not going to be any way to objectively test for it, or define it more clearly.

After two years of confinement I have exhibited several of the symptoms associated with long covid. I have done an asymptomatic COVID, so by all definition, I do suffer of long COVID. Of course it could also be due to the fact that I am just generally getting older, being more tired and having a bit more headaches. Also, like many people I am doing a bit less sports than I used to, and my alcohol consumption has incr…

So how do you measure it then?

Because if you're saying "self diagnosis is the wrong way", but there is no other way yet, you're effectively saying you don't believe anyone who has it has it. And that isn't helpful.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#45

Post by kennywinker »

robonerd wrote: post #32
kennywinker wrote: post #24

Earlier quoted context omitted.

I think at this point diagnosing long covid necessarily involves trusting patients. If you had no chronic illness symptoms you were aware of, and then get covid, and then have chronic illness symptoms - that's long covid. Until we understand what it is better, there's not going to be any way to objectively test for it, or define it more clearly.

> If you had no chronic illness symptoms you were aware of, and then get covid, and then have chronic illness symptoms - that's long covid. Or a coincidence.. Not an unlikely one either, given the broad and vague set of symptoms.

Sure, but until we know what it is and how to measure if you have it - there is no difference between a coincidence and it. Would you rather we tell everybody who says they have it they don't, or accept everybody's self-assessment? Because until we have a way to diagnose it using an objective measure, those are the options.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#46

Post by IMTDb »

kennywinker wrote: post #44
IMTDb wrote: post #39

Earlier quoted context omitted.

After two years of confinement I have exhibited several of the symptoms associated with long covid. I have done an asymptomatic COVID, so by all definition, I do suffer of long COVID. Of course it could also be due to the fact that I am just generally getting older, being more tired and having a bit more headaches. Also, like many people I am doing a bit less sports than I used to, and my alcohol consumption has incr…

So how do you measure it then? Because if you're saying "self diagnosis is the wrong way", but there is no other way yet, you're effectively saying you don't believe anyone who has it has it. And that isn't helpful.

As per my message: we have the CT scan/Xray to the chest showing clear signs of reduced lungs capacity following a COVID infection. Let's call this "doctor diagnosed long covid".

We also have the other self reported symptom. Because it's crazy to give it the same name, let's give it another one. We might call it the "I am feeling less well than 2 years ago" disease. It's a very common one.

Now the "I am feeling less well than 2 years ago" disease might have many origin. COVID being one of them. But considering that it has been rampant for years before COVID appeared, it's unlikely that it is the main origin of it.

According to me, it's not up to patient to diagnose it, just like we don't let patient self-diagnose brain cancer after letting them read 5 health article on Google otherwise everyone would have it - you know that joke, since why shouldn't it apply to COVID as well ? And since "long COVID" is discussed everywhere online and in the media, so it's natural people will associate with that, that does not make it true.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#47

Post by dominotw »

KevinGlass wrote: post #16
dominotw wrote: post #7

Earlier quoted context omitted.

Not sure why this is downvoted. I am not qualified to read the paper but I have the same question. My impression was that "long covid" was self reported and there is no way to medically confirm if someone is actually has "long covid"

How can you medically confirm someone has depression, chronic pain, or anxiety? You can't with diagnostic tests but you can observe their behavior and ask them. "Long Covid" is extremely similar to other post viral illnesses that have been observed for decades, just getting more attention now.

I can say my left toe is hurting from long covid and no one can deny that. But if you say my left toe is hurting from depression that won't be taken seriously.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#48

Post by jrnichols »

IMTDb wrote: post #39
kennywinker wrote: post #24

Earlier quoted context omitted.

I think at this point diagnosing long covid necessarily involves trusting patients. If you had no chronic illness symptoms you were aware of, and then get covid, and then have chronic illness symptoms - that's long covid. Until we understand what it is better, there's not going to be any way to objectively test for it, or define it more clearly.

After two years of confinement I have exhibited several of the symptoms associated with long covid. I have done an asymptomatic COVID, so by all definition, I do suffer of long COVID. Of course it could also be due to the fact that I am just generally getting older, being more tired and having a bit more headaches. Also, like many people I am doing a bit less sports than I used to, and my alcohol consumption has incr…

"long covid" is also going to be a goldmine for research funding for years to come, so it's not surprising that the term remains so vague.

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#49

Post by dang »

kens wrote: post #23

The title here ("100% of Long Covid patients have GPCR-autoantibodies") is editorialized, making this sound interesting. The actual title is "Possible Impact of functional active GPCR-autoantibodies on retinal microcirculation in Long-COVID." The study looked at 76 long covid patients with no control group, so you can't make a general conclusion from it. This post is a waste of time unless you're interested in obscur…

Thanks - I've changed it to the original title now (or rather, a truncated version to fit HN's 80 char limit).

Submitters: please follow the site guidelines, which ask: "Please use the original title, unless it is misleading or linkbait; don't editorialize."

Re: Possible impact of functional active gpcr-autoantibodies in long Covid

#50

Post by AndrewUnmuted »

nicoburns wrote: post #8
AndrewUnmuted wrote: post #4

What is "Long COVID" and how was it proved that all participants in the study "have" it?

Long covid is ongoing chronic illness symptoms following a covid infection, including but not limited to fatigue, heart problem, lung problems, brain fog, and auto-immune problems.

You're a loser.
Post reply on HN