If you're interested in high performance video processing with Python and want something more than just a fancy ffmpeg wrapper, then I can highly recommend checking out Vapoursynth: https://www.vapoursynth.com/ It's been around for ~9 years and has a relatively large community around it, most visibly found on the Doom9 forums: http://forum.doom9.org/forumdisplay.php?f=82 I'm personally still mostly using Avisynth the…
For those desiring a GUI interface around VapourSynth and other advanced A/V processing tools, I strongly recommend StaxRip: https://github.com/staxrip/staxrip
Not a full blown GUI, but it shows you a video preview, syntax highlighting, function definitions for plugins, etc. It doesn't support Vapoursynth, but you can program macros in Python.