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FDA approves first monthly injectable to treat HIV infection

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Re: FDA approves first monthly injectable to treat HIV infection

#41
post #35

Earlier quoted context omitted.

No, that's not the reason, given that PrEP exists. The actual reason is that Truvada, like other healthcare, can be hard to get in the American system.

Have we considered telling people to "just stay home" and to "not have sex"? Maybe that's the trick.

Right. Abstinence doesn't really work in the real world, only in the spherical-cow world where humans are perfectly obedient.

Re: FDA approves first monthly injectable to treat HIV infection

#42

Earlier quoted context omitted.

Instead of downvotes, I'm curious what evidence there is on either side of this claim.

The claim logically holds together. There is even evidence on its side. But one reason for the downvotes may be that it might be too narrow-minded. For one thing, it completely neglects to consider the relative difficulty of treating symptoms versus being fully curative. Secondly, it half undermines itself by lumping vaccines into the same bucket as symptomatic treatment. Clearly the economic incentives for vaccine,…

The claim doesn't logically hold together: it assumes a monopoly in medicine. It might not be profitable for the company with a treatment regimen to develop a cure. But for the company without the treatment regiment to develop a cure and take away all of a competitor's business and capture a significant part of it as their own? That's extremely profitable. You can charge far more for a cure than for a regular preventative treatment (per dose) so margins are far higher even if volume over time is lower. Suffice it to say cures are sufficiently profitable to enough of the actors in the system that they are worth exploring. And there is evidence of cures being researched successfully as referenced in the comment above. Also, I don't think all pharma companies are perfectly 'rational' actors in this sense. They are composed of people who got into medicine with the interest to help people, and those people know both cures and vaccines help more than just symptom mitigation. The motivation of the actors in the system to do good leads to even more research of cures and vaccines than the non-zero amount that is sufficiently incentivized (even if cures are less profitable than symptom mitigations).

Re: FDA approves first monthly injectable to treat HIV infection

#43

> In 2018, for instance, there were approximately 36,400 newly infected patients living with HIV in the U.S. This number seems insane to me in the USA . Why is a well known deadly disease, with well understood transmission vectors, still spreading so prominently here?

Ronald Reagan had a hand to play in this, and the AIDS epidemic in america can be seen as the real birth of the neoconservative movement in united states' politics.

Regan refused to even acknowledge the disease until he couldn't get away. This put the US on a deficit addressing AIDS that continues to this day.

American Republicanism kills people.

Re: FDA approves first monthly injectable to treat HIV infection

#44
I'm hopeful that this is a step towards getting an injectable on a longer time scale even though it's likely the treatment technology would be different. If we could get to something on a 2-year or 5-year time horizon we may just start giving it to everyone preventatively, the way we do tetanus shots. The larger volume might mean enough total profits at a price scale that makes it affordable for the pharma company to do that at a price point that makes sense for the buyer. If we get to a universal treatment that we can apply globally, we may see AIDS become a thing of the past in a few generations. Given unequal access to care that may be substantially challenging in regions with poor health care and we may need an outright vaccine that lasts permanently to successfully treat it globally. But this seems to be a step along that pathway even if new technologies are needed to complete it.

Re: FDA approves first monthly injectable to treat HIV infection

#45
post #35

Earlier quoted context omitted.

Because people really, really like having risky and unsafe sex?

No, that's not the reason, given that PrEP exists. The actual reason is that Truvada, like other healthcare, can be hard to get in the American system.

The incidence rate of HIV infection is the same in the US as it is in France, Span, or Italy though higher than the Scandinavian countries. I couldn't easily find data for the current rate of new infections, but its not immediately obvious to me that access to health care is the major driving factor.

https://en.wikipedia.org/wiki/List_of_countries_by_HIV/AIDS_...

Re: FDA approves first monthly injectable to treat HIV infection

#46

> In 2018, for instance, there were approximately 36,400 newly infected patients living with HIV in the U.S. It's 2021, why are we only seeing 3 year old HIV infection numbers? How come I can see coronavirus infection numbers updated pretty much hourly but reporting on HIV infection rates in this country is lagging 3 years?

Neither should be reported as they're lifestyle ailments, ailments that occur as a result of poor lifestyle choices.

Re: FDA approves first monthly injectable to treat HIV infection

#47
post #9

Earlier quoted context omitted.

https://www.ncbi.nlm.nih.gov/books/NBK217902/ https://fee.org/articles/curing-diseases-is-sustainable-gove... https://www.bmj.com/content/363/bmj.k4351 https://theconversation.com/amp/how-pharmaceutical-companies... https://yaledailynews.com/blog/2017/02/09/lewis-the-need-for... https://www.medpagetoday.com/blogs/revolutionandrevelation/7... https://pnhp.org/news/eliminate-the-profit-motive-in-health-...

Many of these seem to support GP's comment.

I don't really understand the downvotes and reactions of the other commenters to the gp's post. There's a whole bunch of studies showing there's less incentive to find cures opposed to ongoing treatments under for profit health systems.

On a website where products as a service are discussed regularly i'm confused as to how the parallels between that and profit driven 'healthcare as a service' are ignored or looked at with hostility.

Re: FDA approves first monthly injectable to treat HIV infection

#48

> In 2018, for instance, there were approximately 36,400 newly infected patients living with HIV in the U.S. This number seems insane to me in the USA . Why is a well known deadly disease, with well understood transmission vectors, still spreading so prominently here?

Because people don't have healthcare. We've decided as a society that it's better for undesirable people (gay men, IV drug users) to die instead of paying a cent more than we absolutely must in taxes.

Re: FDA approves first monthly injectable to treat HIV infection

#49

> In 2018, for instance, there were approximately 36,400 newly infected patients living with HIV in the U.S. It's 2021, why are we only seeing 3 year old HIV infection numbers? How come I can see coronavirus infection numbers updated pretty much hourly but reporting on HIV infection rates in this country is lagging 3 years?

COVID takes a few days to show symptoms and get diagnosed. HIV takes a lot longer. https://www.onlineathens.com/news/2017-11-28/cdc-lag-time-be... > In their monthly Vital Signs report out Tuesday, the Centers for Disease Control and Prevention reported that the median time between infection and diagnosis with HIV was three years in 2014, about seven months shorter than in 2011. If you got HIV in 2020, chances are yo…

I understand that, but I don't see what is so complicated about reporting # of HIV tests conducted in a certain timeframe (daily, monthly, whatever) and what portion of those tests came back positive, just like we currently do with coronavirus. It doesn't matter what the lag time is in between being exposed and receiving a positive test. What we are interested in is # of positive tests, why is there a 3 year lag here?

Re: FDA approves first monthly injectable to treat HIV infection

#50
post #35

Earlier quoted context omitted.

No, that's not the reason, given that PrEP exists. The actual reason is that Truvada, like other healthcare, can be hard to get in the American system.

The incidence rate of HIV infection is the same in the US as it is in France, Span, or Italy though higher than the Scandinavian countries. I couldn't easily find data for the current rate of new infections, but its not immediately obvious to me that access to health care is the major driving factor. https://en.wikipedia.org/wiki/List_of_countries_by_HIV/AIDS_...

I don't know enough to comment on European countries, but I wouldn't be surprised if access was a big problem there as well. The American healthcare system is pretty bad, but it's not the only bad system in existence. There may be other linked factors like stigma at play as well.
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