Anti-Aging: State of the Art • Hacker News Board

Re: Anti-Aging: State of the Art

#41

Post by abrichr » Sat, Jan 02, 2021, 4:26 PM UTC

maria_weber23 wrote: post #34

abrichr wrote: post #31

Earlier quoted context omitted.

> calorie free sweeteners Could you please provide some evidence for how these impact longevity? Especially those from natural sources, e.g. stevia and monk fruit. Not trying to be snarky, just genuinely curious!

Well for one, natural sweeteners interfere with the bodies insulin response. I.e. it will overproduce in anticipation, but then your blood sugar drops into oblivion, because well, you didn't actually eat sugar. Is this bad? Probably not if you don't overuse them. Besides that? I can tell you my body is very sensitive and artificial sweeteners (I literally tried all different kinds) make hell break lose in it, much wo…

Thanks for the information. After a bit of research I found this study from May 2020:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7257251/

> Artificial sweeteners are related to non-alcoholic fatty liver disease: Microbiota dysbiosis as a novel potential mechanism

> Non-alcoholic fatty liver disease (NAFLD) is a systemic and wide-spread disease characterized by accumulation of excess fat in the liver of people who drink little or no alcohol. Artificial sweeteners (ASs) or sugar substitutes are food additives that provide a sweet taste, and are also known as low-calorie or non-calorie sweeteners. Recently people consume increasingly more ASs to reduce their calorie intake. Gut microbiome is a complex ecosystem where 1014 microorganisms play several roles in host nutrition, bone mineralization, immune system regulation, xenobiotics metabolism, proliferation of intestinal cells, and protection against pathogens. A disruption in composition of the normal microbiota is known as ‘gut dysbiosis’ which may adversely affect body metabolism. It has recently been suggested that dysbiosis may contribute to the occurrence of NAFLD. The aim of the present study was to investigate the effects of ASs on the risk of NAFLD. The focus of this review is on microbiota changes and dysbiosis. Increasing evidence shows that ASs have a potential role in microbiota alteration and dysbiosis. We speculate that increased consumption of ASs can further raise the prevalence of NAFLD. However, further human studies are needed to determine this relationship definitively.

Re: Anti-Aging: State of the Art

#42

Post by mleonhard » Sat, Jan 02, 2021, 7:10 PM UTC

jelliclesfarm wrote: post #39

kkoncevicius wrote: post #7

I find majority of anti-aging articles to be way too optimistic. Consider the following: We still cannot treat many well understood diseases, including tuberous sclerosis, allergies, asthma, etc. We don't know the exact cause of multiple sclerosis, Parkinson's disease, type 2 diabetes, etc, despite studying those diseases for decades. We can't help you keep the color of your hair or regrow your missing teeth, despite…

The key is regrowing teeth and keeping hair colour..because that’s the crux of rejevenuation. One of the crudest forms of medicine is dentistry. It’s a very brute force method of replacing lost parts. Teeth are the extension of our bodies and it’s connected to every aspect of life. It’s similar to a living organ and is the sum total of our health. And what do we do with tooth loss? We replace it cosmetically and func…

> It is known that plaque in teeth is indicative of heart plaque.

Would you please link to some information about this?

Re: Anti-Aging: State of the Art

#43

Post by mrfusion » Sat, Jan 02, 2021, 9:46 PM UTC

baccheion wrote: post #32

Sustained-release melatonin before bed (minimum dose to maintain youthful serum; eg, REMfresh). Balance with vitamin D3 (+ K2) in the morning. Meet all RDAs with just a variety of whole quality foods. Last meal 3-4 hours before bed or earlier to not ruin hGH/IGF-1 release during first few hours of sleep. 2:2:1-2 calcium:phosphorus:magnesium ratio.

How about protein before bed if you’re getting a lot of exercise and looking for muscle gains? Or still bad?

Re: Anti-Aging: State of the Art

#44

Post by jelliclesfarm » Sat, Jan 02, 2021, 10:53 PM UTC

mleonhard wrote: post #42

jelliclesfarm wrote: post #39

Earlier quoted context omitted.

The key is regrowing teeth and keeping hair colour..because that’s the crux of rejevenuation. One of the crudest forms of medicine is dentistry. It’s a very brute force method of replacing lost parts. Teeth are the extension of our bodies and it’s connected to every aspect of life. It’s similar to a living organ and is the sum total of our health. And what do we do with tooth loss? We replace it cosmetically and func…

> It is known that plaque in teeth is indicative of heart plaque. Would you please link to some information about this?

https://www.medicalnewstoday.com/articles/how-is-gum-disease... (2020)

Also: https://www.health.harvard.edu/heart-health/gum-disease-and-... (2018)

Re: Anti-Aging: State of the Art

#45

Post by t0s » Sat, Jan 02, 2021, 11:12 PM UTC

jmiskovic wrote: post #33

kkoncevicius wrote: post #7

I find majority of anti-aging articles to be way too optimistic. Consider the following: We still cannot treat many well understood diseases, including tuberous sclerosis, allergies, asthma, etc. We don't know the exact cause of multiple sclerosis, Parkinson's disease, type 2 diabetes, etc, despite studying those diseases for decades. We can't help you keep the color of your hair or regrow your missing teeth, despite…

Scepticism is healthy. That said, aging affects 100% of population and is lethal. The amount of funding & effort should be orders of magnitude larger than for any of diseases you mentioned. I'm reading through Sinclair's book "Lifespan - Why We Age and Why We Don’t Have To" and I find it fascinating (especially the chapter on origins of life and proto-genes of aging). When Sinclair talks about time-scales, he makes c…

Interesting! Is this book approachable by someone who knows nothing regarding biology/medicine/etc ? Thanks

Re: Anti-Aging: State of the Art

#46

Post by rishav_sharan » Sun, Jan 03, 2021, 7:51 AM UTC

novok wrote: post #11

domenicd wrote: post #4

As someone already totally on board with ending aging, I found this article not terribly helpful. My main questions are "what should I be doing right now to stop my own body from aging?" and "when will more stuff be available for me to do that is not currently?" The article didn't help much in this regard. As far as I can tell, there are a number of clinical trials I should watch to see if those drugs work in humans?…

Do you avoid sugar, fructose, calorie free sweeteners? Do you do strength training & cardio? Are you overweight? Is your waist to hip ratio ideal for your gender? Do you monitor your blood glucose? Get 8 hours of sleep consistently? Avoid stress? Do not live close to a highway / live in a place with high air quality? Get consistent screening for issues that your family has to catch them early? Get enough sunshine? Re…

Add one more from a previous thread on similar topics; regularly donate blood. Forcing your marrows to create new blood often seems to have a great effect on joint and heart problems.

Re: Anti-Aging: State of the Art

#47

Post by kgin » Sun, Jan 03, 2021, 7:55 AM UTC

t0s wrote: post #45

jmiskovic wrote: post #33

Earlier quoted context omitted.

Scepticism is healthy. That said, aging affects 100% of population and is lethal. The amount of funding & effort should be orders of magnitude larger than for any of diseases you mentioned. I'm reading through Sinclair's book "Lifespan - Why We Age and Why We Don’t Have To" and I find it fascinating (especially the chapter on origins of life and proto-genes of aging). When Sinclair talks about time-scales, he makes c…

Interesting! Is this book approachable by someone who knows nothing regarding biology/medicine/etc ? Thanks

Very much so. It's written for an interested and intelligent general audience.

Re: Anti-Aging: State of the Art

#48

Post by deegles » Sun, Jan 03, 2021, 5:59 PM UTC

iridium_core wrote: post #22

phkahler wrote: post #19

Earlier quoted context omitted.

I cured my asthma with Iodine and Magesium. Iodine also seems to help type II according to some doctors. Progress is slow, and I agree that most anti-aging results are over hyped.

We need automated and mainstream Vitamin and Mineral testing - without needing to go through the traditional healthcare system.

Theranos probably set that goal back a decade.

Re: Anti-Aging: State of the Art

#49

Post by baccheion » Fri, Jan 15, 2021, 2:41 AM UTC

mrfusion wrote: post #43

baccheion wrote: post #32

Sustained-release melatonin before bed (minimum dose to maintain youthful serum; eg, REMfresh). Balance with vitamin D3 (+ K2) in the morning. Meet all RDAs with just a variety of whole quality foods. Last meal 3-4 hours before bed or earlier to not ruin hGH/IGF-1 release during first few hours of sleep. 2:2:1-2 calcium:phosphorus:magnesium ratio.

How about protein before bed if you’re getting a lot of exercise and looking for muscle gains? Or still bad?

I don't believe gains are that fragile. IGF-1 has a longer half-life.

More important is overall surplus (hard gainers need more), nutrition, regular gym time, and low stress/catabolism. Normalize cortisol, insulin, and thyroid/HPTA/metabolism.