Oxford University breakthrough on global COVID-19 vaccine • Hacker News Board

Re: Oxford University breakthrough on global COVID-19 vaccine

#41

Post by jakozaur » Mon, Nov 23, 2020, 8:12 AM UTC

Title is misleading. They tested few configurations, we should use the most optimal one, not the average. Much better source: https://www.astrazeneca.com/media-centre/press-releases/2020...

Good:

+ likely 90% effective if we use optimal dosing

+ no significant side effective. Looks better than Pfizer or Moderna.

+ already pre-produced at huge scale, 3 Bln doses in 2021

+ easy to store and administer, just regular fridge required

+ several times cheaper than mRNA

+ more traditional vaccine than novel mRNA, less tail risk in production and scaling up the process

Not good:

- two doses, efficient one month after first injection

- likely public will be confused about efficiency due to dosing regime

Re: Oxford University breakthrough on global COVID-19 vaccine

#42

Post by singingfish » Mon, Nov 23, 2020, 8:12 AM UTC

wereHamster wrote: post #38

mcdowall wrote: post #5

The key differentiator here is the storage requirements (2-8c ‘normal refrigerator’). That’s much more accessible to developing / low GDP countries as opposed the cumbersome and expensive storage requirements of the other two.

What are the storage requirements for the other two?

-20c and -70c from what I remember

Re: Oxford University breakthrough on global COVID-19 vaccine

#43

Post by [deleted] » Mon, Nov 23, 2020, 8:13 AM UTC

wereHamster wrote: post #38

mcdowall wrote: post #5

The key differentiator here is the storage requirements (2-8c ‘normal refrigerator’). That’s much more accessible to developing / low GDP countries as opposed the cumbersome and expensive storage requirements of the other two.

What are the storage requirements for the other two?

[deleted]

Re: Oxford University breakthrough on global COVID-19 vaccine

#44

Post by [deleted] » Mon, Nov 23, 2020, 8:13 AM UTC

camkego wrote: post #16

This statement seems a big deal: "There were no hospitalised or severe cases in anyone who received the vaccine" Is that also true of the Pfizer and Moderna trials? Are the various trials measuring 'effectiveness' in the same way? Is there a standard for 'effectiveness' in these Covid-19 trials? It will take some digging and real effort to compare the risks and benefits of the various vaccines coming to market.

[deleted]

Re: Oxford University breakthrough on global COVID-19 vaccine

#45

Post by afterburner » Mon, Nov 23, 2020, 8:14 AM UTC

jakozaur wrote: post #41

Title is misleading. They tested few configurations, we should use the most optimal one, not the average. Much better source: https://www.astrazeneca.com/media-centre/press-releases/2020... Good: + likely 90% effective if we use optimal dosing + no significant side effective. Looks better than Pfizer or Moderna. + already pre-produced at huge scale, 3 Bln doses in 2021 + easy to store and administer, just regular fri…

The two existing mRNA vaccines touted earlier also require two doses.

Re: Oxford University breakthrough on global COVID-19 vaccine

#46

Post by singingfish » Mon, Nov 23, 2020, 8:14 AM UTC

ksec wrote: post #31

Incoming possible Silly, Stupid and Lazy Questions, 1. Are there any vaccine ( of any Disease ) that are 100% effective? Or do we operate ( as I would assume ) something like 5 Nines effective rate and call it 100%? 2. Across all type of Vaccine, what are the average or median effective rate? i.e Should we expect Vaccine to be 90%+ effective in the first place? Or is that a wrong expectation to make? 3. What happens…

1. Smallpox vaccine is 100% effective 2. 90% is high. 3. Probably not. Immune systems are weird and incredibly complicated (think even more complicated than the brain).

Re: Oxford University breakthrough on global COVID-19 vaccine

#47

Post by SpaceRaccoon » Mon, Nov 23, 2020, 8:14 AM UTC

threeseed wrote: post #21

camkego wrote: post #16

This statement seems a big deal: "There were no hospitalised or severe cases in anyone who received the vaccine" Is that also true of the Pfizer and Moderna trials? Are the various trials measuring 'effectiveness' in the same way? Is there a standard for 'effectiveness' in these Covid-19 trials? It will take some digging and real effort to compare the risks and benefits of the various vaccines coming to market.

There were no hospitalisations or severe incidents for either the Pfizer and Moderna trials were was related to the vaccine. And it's pretty easy to compare the vaccines. It will mostly come down to price, ease of manufacture and ease of distribution i.e. temperature. Given that for the 3 viruses all have no risks associated with their use.

How do we know there aren't long term side effects?

Re: Oxford University breakthrough on global COVID-19 vaccine

#48

Post by ksec » Mon, Nov 23, 2020, 8:14 AM UTC

dragontamer wrote: post #36

ksec wrote: post #31

Incoming possible Silly, Stupid and Lazy Questions, 1. Are there any vaccine ( of any Disease ) that are 100% effective? Or do we operate ( as I would assume ) something like 5 Nines effective rate and call it 100%? 2. Across all type of Vaccine, what are the average or median effective rate? i.e Should we expect Vaccine to be 90%+ effective in the first place? Or is that a wrong expectation to make? 3. What happens…

> 2. Across all type of Vaccine, what are the average or median effective rate? i.e Should we expect Vaccine to be 90%+ effective in the first place? Or is that a wrong expectation to make? Sometimes, vaccines are only 30% or 40% effective, leading to terrible flu seasons. I don't really know the mean/median/mode, but 90% is really high for a vaccine. > 3. What happens in the case of 10% ineffective, do they take a t…

>How do you know if someone is one of those 10%?

I would assume everyone have the vaccine and they still get caught COVID afterwards?

Or do I misunderstood what effective means?

Re: Oxford University breakthrough on global COVID-19 vaccine

#49

Post by pvsukale3 » Mon, Nov 23, 2020, 8:15 AM UTC

wereHamster wrote: post #38

mcdowall wrote: post #5

The key differentiator here is the storage requirements (2-8c ‘normal refrigerator’). That’s much more accessible to developing / low GDP countries as opposed the cumbersome and expensive storage requirements of the other two.

What are the storage requirements for the other two?

-80ºC for Pfizer vaccine and -20ºC for mRNA vaccine. https://www.npr.org/sections/health-shots/2020/11/17/9355633...

Re: Oxford University breakthrough on global COVID-19 vaccine

#50

Post by throwawayiionqz » Mon, Nov 23, 2020, 8:15 AM UTC

mcdowall wrote: post #5

The key differentiator here is the storage requirements (2-8c ‘normal refrigerator’). That’s much more accessible to developing / low GDP countries as opposed the cumbersome and expensive storage requirements of the other two.

Another huge differentiator is price. At $3 to $4, many countries will jump on board ASAP and stay away from the expensive vaccines from Pfizer and Moderna.