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Pfizer submits Covid vaccine to FDA for approval, to distribute in December

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Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#41

Post by tuna-piano »

Jaruzel wrote: post #25
tuna-piano wrote: post #18

-Great great news. Can't wait to get the needle in the arm ASAP. -Seems extremely effective at limiting covid disease. -Very curious as to how long will the vaccine immunity will last? -Seems with the second dose for 18-55 year olds, perhaps 75% will feel fatigue, 50% have chills and 20% will have a fever.[1] This hasn't been widely shared yet and I'm a bit concerned how the public will react. -Safety: Given the huge…

Seems with the second dose for 18-55 year olds, perhaps 75% will feel fatigue, 50% have chills and 20% will have a fever.[1] This hasn't been widely shared yet and I'm a bit concerned how the public will react. Isn't the Flu vaccine side effects the same though?

Looks like for fever, flue vaccine is more like 1-2%. So maybe 10-20x more fever with this vaccine than flu vaccine.

https://www.washingtonpost.com/health/flu-shot-facts/2020/09...

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#42

Post by mindcrime »

gvv wrote: post #29

Well just like I don't immediately update to the latest OS I think I'll wait for the beta testing to happen :)

Same. I'm not an anti-vaxxer or anything like that. But I think "don't use version 1.0" advice applies here just like it does for software. Especially given the possibility that things have been "hurried" in the name of expediency in terms of getting the vaccine(s) developed, tested, and approved.

The good news, in a sort of perverse sense, is that some delay to see what happens with "early adopters" is kinda inevitable anyway, due to the distribution logistics. Unless you're a health care provider, first responder, or in a high risk group, you'll probably have to wait a while to get access to the vaccine even if you want to take "version 1.0".

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#43

Post by chadash »

qwerty456127 wrote: post #16
DSingularity wrote: post #3

Does this feel rushed to anyone? Why don’t they stagger the release? Why jump from initial trials involving thousands to widespread distribution involving millions?

Despite being extremely pro-vac I'm going to postpone getting vaccinated with this for as long as possible (at least a couple of years hopefully). Even if they would disallow me to travel abroad I would rather stay in my home country. I've heard about a guy who volunteered to try the Russian vaccine - he got extremely sick and almost died from inflammatory cardiomyopathy as the result. So I want to see thousands of p…

I heard about several guys who died or were seriously injured by Covid. I know a few of them personally. Pick your poison.

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#44

Post by solarhoma »

gvv wrote: post #29

Well just like I don't immediately update to the latest OS I think I'll wait for the beta testing to happen :)

Do you think private companies will require vaccination to return to work?

*Here is an article I found on the subject. Essentially stating in general employers could require vaccination. https://www.usatoday.com/story/money/2020/08/26/coronavirus-...

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#45

Post by Erlich_Bachman »

tuna-piano wrote: post #18

-Great great news. Can't wait to get the needle in the arm ASAP. -Seems extremely effective at limiting covid disease. -Very curious as to how long will the vaccine immunity will last? -Seems with the second dose for 18-55 year olds, perhaps 75% will feel fatigue, 50% have chills and 20% will have a fever.[1] This hasn't been widely shared yet and I'm a bit concerned how the public will react. -Safety: Given the huge…

Not sure why you are being downvoted. Those are legitimate concerns. This vaccine has only been tested for a small number of months. We simply don't know whether it is safe long-term and what exact statistical level of safety it has. This is not some quasi-scientific bullshit about energies, these are simple medical facts. We have not been testing them. Testing is the only scientific method that matters.

I don't think anyone is saying that we should never sell any vaccine before it has been tested for 100+ years, that's obviously impossible. But to ignore obvious concerns is just religious scientifism in the worst possible sense.

These are good concerns for any medication.

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#46

Post by tuna-piano »

nojito wrote: post #34
tuna-piano wrote: post #18

-Great great news. Can't wait to get the needle in the arm ASAP. -Seems extremely effective at limiting covid disease. -Very curious as to how long will the vaccine immunity will last? -Seems with the second dose for 18-55 year olds, perhaps 75% will feel fatigue, 50% have chills and 20% will have a fever.[1] This hasn't been widely shared yet and I'm a bit concerned how the public will react. -Safety: Given the huge…

>Other vaccines have been pulled from the market for safety reasons This isn't true at all. There has been 2 voluntary recalls due to manufacturing issues which not led to any health problems.

I don't believe that's an accurate statement. Problems have been rare, but not unheard of.

A list here for the US (most of the listed vaccines on the page were later found not concerning):

https://www.cdc.gov/vaccinesafety/concerns/concerns-history....

-The results of the investigations showed that RotaShield vaccine caused intussusception in some healthy infants younger than 12 months of age who normally would be at low risk for this condition... the manufacturer voluntarily withdrew RotaShield from the market in October 1999.

-...that people who received the 1976 swine influenza vaccine had an increased risk for developing GBS .

-And the very recent Dengue vaccine made by Sanofi, which was given to 700k people. "Sanofi had found evidence that the vaccine increases the risk of hospitalization and cytoplasmic leakage syndrome in children who had no prior exposure to dengue, regardless of age."[1][2]

[1]https://www.npr.org/sections/goatsandsoda/2019/05/03/7190377...

[2]https://en.wikipedia.org/wiki/Dengvaxia_controversy

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#47

Post by klmadfejno »

nojito wrote: post #17
klmadfejno wrote: post #12

Earlier quoted context omitted.

> 95% with a p of That can't possibly be true. Not to diminish the accomplishment though.

How is it not true? Most are 85-90% but the jump from high 80s --> 95% is massive,

Well a one second google search says chickenpox is 98% effective, so already that's not unheard of.

I would think extremely low p values are not just normative, but required for a vaccine to reach public acceptance. This vaccine is noteworthy for the speed at which it was developed, but its not the first really good vaccine.

edit: and because I'm getting a lot of downvotes for some reason, Anthrax, Measles, Rubella, and Polio also seem to have 90%+ effectiveness ratings.

edit edit: and as a corollary, with equivalent n sizes for the trials and higher effect sizes, the p value is by necessity smaller, not that it matters below very small thresholds

edit^3: high 80s to 95 isn't that noteworthy, and is likely within the margin of error of the clinical trials.

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#48

Post by strombofulous »

solarhoma wrote: post #44
gvv wrote: post #29

Well just like I don't immediately update to the latest OS I think I'll wait for the beta testing to happen :)

Do you think private companies will require vaccination to return to work? *Here is an article I found on the subject. Essentially stating in general employers could require vaccination. https://www.usatoday.com/story/money/2020/08/26/coronavirus-...

I hope so. I would be upset if I got the vaccine and people who didn't have it were allowed to work near me, but I would just keep WFH. I would be outraged if I were forced to work with them

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#49

Post by pritovido »

DSingularity wrote: post #3

Does this feel rushed to anyone? Why don’t they stagger the release? Why jump from initial trials involving thousands to widespread distribution involving millions?

For me the testing process feels painful and slow. I believe the best way to know the illness is through controlled infection of volunteers. I would have volunteered myself.

I have been around people risking their lives in B.A.S.E jumps, scuba diving or aircraft acrobatics.

If people can risk their own lives for the adrenaline rush, I don't know why they can't risk their lives for the improvement of all humanity.

Re: Pfizer submits Covid vaccine to FDA for approval, to distribute in December

#50

Post by nojito »

mindcrime wrote: post #42
gvv wrote: post #29

Well just like I don't immediately update to the latest OS I think I'll wait for the beta testing to happen :)

Same. I'm not an anti-vaxxer or anything like that. But I think "don't use version 1.0" advice applies here just like it does for software. Especially given the possibility that things have been "hurried" in the name of expediency in terms of getting the vaccine(s) developed, tested, and approved. The good news, in a sort of perverse sense, is that some delay to see what happens with "early adopters" is kinda inevita…

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