Old Dogs, New Research and the Secrets of Aging • Hacker News Board

Re: Old Dogs, New Research and the Secrets of Aging

#41

Post by panopticon » Sat, Nov 14, 2020, 1:23 AM UTC

slacka wrote: post #22

From my grandparent to me, there has always been German Shepherds in our family. Starting the 80's all of our dogs started dying much earlier, ~6-7 of cancer. In the early 2000's, we switched to raw diet from premium store bought kibble to raw. Sure enough, not only did their coat improve not a single cancer death under age of 13. I know it's anecdotal, but in my dog world circle and family, we've all observed simila…

The handful of dogs I knew that broke 18+ years were mutts on garbage kibble like Ol' Roy. And these were medium-sized dogs (30-50lbs), not Chihuahuas.

Anyone I know who can afford to feed their dogs raw also generally get purebred or "designer breed" dogs, and they've all lead shorter lives with more diseases (cancers, autoimmune disorders, bone problems, etc).

My anecdotal experience leads me to believe that breeding practices are a bigger part of the problem, but these are quite small sample sizes.

Re: Old Dogs, New Research and the Secrets of Aging

#42

Post by 1996 » Sat, Nov 14, 2020, 1:37 AM UTC

api wrote: post #24

drran wrote: post #15

Earlier quoted context omitted.

I take anti-aging drugs for about 10 years. I heard about them at HN.

What's in your stack bruh?

Metformin 1g twice a day

MSM 3g + Vitamin C 1g + NAC 600mg thrice a day

Kimchi (for Vitamin K) at breakfast, Niacinamide from a multivitamin B + Vitamin D 5kUI + Magnesium glycinate at night, with Melatonin 60 mg sublingual at night (20x the doses for sleeping is among other things anti-inflammatory and radioprotective)

Every few months an azythromycin+doxycyclin+vitamin C cure as a senolytic: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6520007/

Every few month a dasatinib+quercetin cure as another senolytic : https://sci-hub.se/10.1146/annurev-pharmtox-050120-105018

BTW dasatinib+quercetin are also in clinical trials NCT02848131 and NCT02874989

Re: Old Dogs, New Research and the Secrets of Aging

#43

Post by cambalache » Sat, Nov 14, 2020, 2:07 AM UTC

season2episode3 wrote: post #21

rantwasp wrote: post #6

aging (and anti-aging medication) has the potential to become the next big thing. My dog is part if the DogAgingProject and it’s really exciting to see some focus on something that impacts all of us.

I have such mixed feelings about this. It's not a great movie but this really does remind me of Elysium, in that we're truly heading for a world where those with means can live indefinitely. And those without means...

I dont understand this argument. Let's for a moment think it will happen (it wont, any actual anti-aging treatment would be immediately commoditized)How is that situation "worse" than the one we have right now?

Re: Old Dogs, New Research and the Secrets of Aging

#44

Post by aaron695 » Sat, Nov 14, 2020, 3:59 AM UTC

You should have your dog on rapamycin.

Assuming you want it healthy and to live longer and can pay for that.

Re: Old Dogs, New Research and the Secrets of Aging

#45

Post by milleramp » Sat, Nov 14, 2020, 4:38 AM UTC

slacka wrote: post #22

From my grandparent to me, there has always been German Shepherds in our family. Starting the 80's all of our dogs started dying much earlier, ~6-7 of cancer. In the early 2000's, we switched to raw diet from premium store bought kibble to raw. Sure enough, not only did their coat improve not a single cancer death under age of 13. I know it's anecdotal, but in my dog world circle and family, we've all observed simila…

I wish I would have known about this a while ago, lost my GSD over 2 years ago with spleen cancer at 11. Still Sprinting up stairs and playing with toys, up to the week before. Still am pissed how it ended.

Re: Old Dogs, New Research and the Secrets of Aging

#46

Post by duskwuff » Sat, Nov 14, 2020, 4:43 AM UTC

Ancalagon wrote: post #30

duskwuff wrote: post #16

Earlier quoted context omitted.

Playing around with the numbers a bit, I think it's pretty seriously wrong. A 6-month old dog is still a child, in dog terms. This formula says they're nearly 20 years old; I'd be inclined to say that the "right" answer is more like 15 years, if not less. A 1-year old dog is beyond adolescence but is still maturing, but this formula says they're 31 years old, well into adulthood. A 5-year old dog is in the prime of t…

Actually I think I agree with your assessment more. None of the age alignments really make a whole lot of sense to me, even for bigger breeds of dogs. Also, I feel like I've noticed adolescent and mischevious behavior in some of our dogs well into the 2-3 age range on occasion This behavior mainly noted for cocker spaniels and Korean jindos

Giant breeds mature much more slowly, taking two to three years to be fully grown, and effectively age faster after they reach that point, to the extent that they'd be considered elderly by eight or nine years. The 16ln(x)+31 formula already overestimates the effective age of young dogs and underestimates for old dogs; taking giant breeds into consideration just makes its failures even worse.

Re: Old Dogs, New Research and the Secrets of Aging

#47

Post by JacobAldridge » Sat, Nov 14, 2020, 5:03 AM UTC

I was a regular at the HN London Meetups, when I was living over there, and fondly remember (after yet another founder anecdote on stage) someone tweeting “Do founders at dog food companies eat their own dog food?”

Many years later two owners of a dog food company attended one of my workshops, so I had the chance to ask them in person. They never had. (Although several younger employees had done so, with no side effects.)

Re: Old Dogs, New Research and the Secrets of Aging

#48

Post by conductr » Sat, Nov 14, 2020, 5:18 AM UTC

> the Vienna study dogs were all Border collies, so I’m a little surprised that any of them were mature. That would suggest a certain calm, a willingness to tilt the head and muse that doesn’t seem to fit the breed, with its desperate desire to be constantly chasing sheep, geese, children or Frisbees.

I had a border collie from 6 weeks through every stage there is. And while I may be biased, I’d counter point that the author is ignorant here.

I’ve been lucky enough to have many “smart breeds” in my life. Labs, shepherds, etc. and the border collie is the most human in personality. They are just extremely smart. But in a different way that makes them seem more human. Like they have reasoning skills at a higher level. Head tilting in this breed is a body language. My dog and I had a full language we spoke based on head tilts, eye movements and other minor body movements. I could nod my head from across a park/field and he knew if he was getting food, water, a ball, if I was calling a route for him to run, or if it was just time to go home to say a few. This body language extended into pretty much all situations. Most people thought/joked he read my mind because it wasn’t like it was sign language. The movements were so subtle people didn’t even notice them. And I could read his movements too.

Any way , I think this is a great breed for this type of study. I certainly remember my dog’s phases fondly and can relate to the basis of the study.

Re: Old Dogs, New Research and the Secrets of Aging

#49

Post by MperorM » Sat, Nov 14, 2020, 8:12 AM UTC

smt88 wrote: post #34

slacka wrote: post #22

From my grandparent to me, there has always been German Shepherds in our family. Starting the 80's all of our dogs started dying much earlier, ~6-7 of cancer. In the early 2000's, we switched to raw diet from premium store bought kibble to raw. Sure enough, not only did their coat improve not a single cancer death under age of 13. I know it's anecdotal, but in my dog world circle and family, we've all observed simila…

Dogs evolved to eat human scraps. Raw diets may be better nutritionally than kibbles, but cooking the same food is more nutritious and much safer[1] than raw food. After talking to board-certified vets who actually research this stuff, I feed my dog home-cooked human-grade food. 1. https://skeptvet.com/Blog/2018/02/yet-another-study-shows-th...

Growing up my mother let us feed our dog whatever leftovers we had after our dinner, which would sometimes be half a steak that one of my siblings didn't finish or a bowl of liver-paté growing stale in the fridge. She'd make up the difference with generic dog food.

Our dog had a clear preference for our food, and it felt deeply wrong when we would feed it only dog food. It was a part of our family why should it not eat like we did?

If I ever adopt a dog for my family, it will be fed the same way.

Re: Old Dogs, New Research and the Secrets of Aging

#50

Post by [deleted] » Sat, Nov 14, 2020, 10:53 AM UTC

duskwuff wrote: post #16

Ancalagon wrote: post #13

Earlier quoted context omitted.

Anecdotally I'm assuming this equation must be breed-specific because I've had a number of dogs 8+ years old that did not appear to act or look very senior.

Playing around with the numbers a bit, I think it's pretty seriously wrong. A 6-month old dog is still a child, in dog terms. This formula says they're nearly 20 years old; I'd be inclined to say that the "right" answer is more like 15 years, if not less. A 1-year old dog is beyond adolescence but is still maturing, but this formula says they're 31 years old, well into adulthood. A 5-year old dog is in the prime of t…

[deleted]