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Projecting the transmission dynamics of SARS-CoV-2 through postpandemic period

science.sciencemag.org

41–50 of 70 posts

Re: Projecting the transmission dynamics of SARS-CoV-2 through postpandemic period

#41
post #30

This paper seems to have every imaginable scenario of which 2022 is a worst case. But, now actual data is starting to come in - such as the extremely interesting serum testing in Scotland (1) - which suggests that the infection rate is much much higher than previously supposed. The Scotland serum testing shows that around 35000 people were infected at a time when only 110 cases were known officially, and strongly sug…

And also a similar study in Germany with similar results [1]. The result is of course to mechanically reduce the fatality rate to a number close to that of the flu (the problem for hospitals being not so much the fatality rate than the high number of infections), and well within the 0.1-1% range that US health authorities have been advertising for a while. Regarding models, it seems 0.15% is the new basis [2]. Even o…

NYC population is 8.4 million. Their death rate is 6,589 (Apr 13). 0.1% of 8.4 million is 8400, that would mean almost everyone in NYC has been infected, I'm not sure that is feasible at the moment.

https://www1.nyc.gov/assets/doh/downloads/pdf/imm/covid-19-d...

Re: Projecting the transmission dynamics of SARS-CoV-2 through postpandemic period

#42
post #39

This paper seems to have every imaginable scenario of which 2022 is a worst case. But, now actual data is starting to come in - such as the extremely interesting serum testing in Scotland (1) - which suggests that the infection rate is much much higher than previously supposed. The Scotland serum testing shows that around 35000 people were infected at a time when only 110 cases were known officially, and strongly sug…

The tests might be inaccurate. Current antibody tests seem to conflate the common cold with covid-19, as they are both coronaviruses. https://edition.cnn.com/2020/04/14/health/coronavirus-antibo...

That is not the case for this study, see here for why:

https://news.ycombinator.com/item?id=22879363

Re: Projecting the transmission dynamics of SARS-CoV-2 through postpandemic period

#43
post #40
post #34

Earlier quoted context omitted.

It happens all the time, in exactly the same sense that people are dying “from” COVID-19 (i.e. usually combined with other morbidities). How much of this pandemic is due to the disease actually being worse than other coronavirus diseases, and how much is simply due to the rapid spread/no pre-existing immunity, remains to be seen. Who else here remembers learning that AIDS patients (people with acquired immunodeficien…

I disagree. I'm unable to find any source with numbers. At best I've seen the statement "it's rarely fatal except in very rare circumstances". Like the flu, you don't die from the flu, but really it's the last straw on top of other issues that pushes people over the edge. But the flu is far more deadly than the common cold, it's misleading to talk about them together like that.

There are no numbers. Nobody has ever bothered to measure it separately from pneumonia. It’s hardly ever tested for or listed under cause of death, even when it’s obviously a factor. Once things change in the aftermath of all of this, we will see if your instinct is correct.

Re: Projecting the transmission dynamics of SARS-CoV-2 through postpandemic period

#44
post #30

This paper seems to have every imaginable scenario of which 2022 is a worst case. But, now actual data is starting to come in - such as the extremely interesting serum testing in Scotland (1) - which suggests that the infection rate is much much higher than previously supposed. The Scotland serum testing shows that around 35000 people were infected at a time when only 110 cases were known officially, and strongly sug…

And also a similar study in Germany with similar results [1]. The result is of course to mechanically reduce the fatality rate to a number close to that of the flu (the problem for hospitals being not so much the fatality rate than the high number of infections), and well within the 0.1-1% range that US health authorities have been advertising for a while. Regarding models, it seems 0.15% is the new basis [2]. Even o…

South Korea’s fatality ratio at the time was obviously lagging, and has since gone above 1%. The true infection fatality rate might still be low but certainly the final case fatality rate won’t be, even with their mass testing.

Re: Projecting the transmission dynamics of SARS-CoV-2 through postpandemic period

#45
post #41
post #30

Earlier quoted context omitted.

And also a similar study in Germany with similar results [1]. The result is of course to mechanically reduce the fatality rate to a number close to that of the flu (the problem for hospitals being not so much the fatality rate than the high number of infections), and well within the 0.1-1% range that US health authorities have been advertising for a while. Regarding models, it seems 0.15% is the new basis [2]. Even o…

NYC population is 8.4 million. Their death rate is 6,589 (Apr 13). 0.1% of 8.4 million is 8400, that would mean almost everyone in NYC has been infected, I'm not sure that is feasible at the moment. https://www1.nyc.gov/assets/doh/downloads/pdf/imm/covid-19-d...

It would only take a 0.25% fatality rate to imply 30% of the NY population to have been infected, which is plausible.

Re: Projecting the transmission dynamics of SARS-CoV-2 through postpandemic period

#46
post #3

Earlier quoted context omitted.

Intermittent seems quite possible. Every time the death rate spikes, we'll have to lock down again. Chances are, some region will decide against doing that, and their outcome will provide a clear incentive for everyone else to be more rigorous about it.

That's happening right now with Sweden and it's sure to be a pretty interesting case study. Their health system hasn't yet been overwhelmed, but they've had a lot of cases (and a lot of deaths), especially on a per capita basis for a smaller country: https://www.theguardian.com/world/2020/apr/15/sweden-coronav... Of course, some right-wing media outlets have still been touting this as a success and a model for a less…

Funny world we’ve come to when right-wingers are pointing to Sweden as an example of how they want to handle an issue.

Re: Projecting the transmission dynamics of SARS-CoV-2 through postpandemic period

#47
post #5

This article brings up something I was thinking about when this all first started: cross-immunity with other coronaviruses and whether or not infection with one of them could at least give partial immunity to SARS-CoV-2. As the study points out, there are less harmful human coronaviruses which are thought to cause around 15% of common colds worldwide. I wonder if anybody has thought to research using these viruses as…

Yeah I’ve been asking about this for a while with no good answers. Why aren’t we looking into whether it would be helpful to enable every healthy person to get the Coronavirus common cold to help boost herd immunity?

Re: Projecting the transmission dynamics of SARS-CoV-2 through postpandemic period

#48
post #39

Earlier quoted context omitted.

The tests might be inaccurate. Current antibody tests seem to conflate the common cold with covid-19, as they are both coronaviruses. https://edition.cnn.com/2020/04/14/health/coronavirus-antibo...

That is not the case for this study, see here for why: https://news.ycombinator.com/item?id=22879363

That is good news if that's the case!

Re: Projecting the transmission dynamics of SARS-CoV-2 through postpandemic period

#49
post #6
post #5

This article brings up something I was thinking about when this all first started: cross-immunity with other coronaviruses and whether or not infection with one of them could at least give partial immunity to SARS-CoV-2. As the study points out, there are less harmful human coronaviruses which are thought to cause around 15% of common colds worldwide. I wonder if anybody has thought to research using these viruses as…

The existing human coronaviruses aren't the most well-researched things around, but as I understand it there's evidence infection with them might actually be pretty dangerous to at-risk people. They just can't cause a pandemic because too many people are immune.

Maybe we could give them to people who aren’t at-risk though, so they are more likely to fight off covid -19 and less likely to transmit it around.

Re: Projecting the transmission dynamics of SARS-CoV-2 through postpandemic period

#50
post #34
post #10

Earlier quoted context omitted.

The common cold is dangerous to people? The flu, sure, but I never heard of people dying from a cold. I'm sure it happens, but in comparable numbers though? I don't think so.

It happens all the time, in exactly the same sense that people are dying “from” COVID-19 (i.e. usually combined with other morbidities). How much of this pandemic is due to the disease actually being worse than other coronavirus diseases, and how much is simply due to the rapid spread/no pre-existing immunity, remains to be seen. Who else here remembers learning that AIDS patients (people with acquired immunodeficien…

Covid-19 is killing healthy young people with no known pre-existing conditions at very high rates. It just happens to be killing the elderly and those with comorbidites (which includes normal ailments like diabetes and obesity) at even higher rates.

It isn’t just some new common cold that we don’t have herd immunity for. Different viruses have different lethality; common cold corona viruses are far milder than SARS-Ncov-2 which is in turn far milder than MERS.

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