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Promising Covid-19 treatment using convalescent serum therapy fast-tracked

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Re: Promising Covid-19 treatment using convalescent serum therapy fast-tracked

#41

Earlier quoted context omitted.

> Apparently - as with other respiratory viral infections - if you don't get it really bad then you may not be immune. Source?

Start here and keep on reading, it is fascinating stuff. https://en.wikipedia.org/wiki/Adaptive_immune_system

I'm not referring the general concept. I've asked for a source that supported the claim that covid19 patients that "don't get it really bad" have been found to not get immune.

Re: Promising Covid-19 treatment using convalescent serum therapy fast-tracked

#42
post #29

Dr. Peter Hotez has been proposing clinical trials of convalescent serum therapy for several weeks now. If it works it could potentially be used both to treat infected patients, and reduce the risk of infection for healthcare workers. https://twitter.com/peterhotez/status/1239387184681177090?la...

I don't know if Dr. Hotez is directly involved, but St. Luke's, which is a Houston-based hospital heavily affiliated with BCM/TCH (where Dr. Hotez works), started trialing this in patients a few days ago.

Re: Promising Covid-19 treatment using convalescent serum therapy fast-tracked

#43

Earlier quoted context omitted.

Start here and keep on reading, it is fascinating stuff. https://en.wikipedia.org/wiki/Adaptive_immune_system

I'm not referring the general concept. I've asked for a source that supported the claim that covid19 patients that "don't get it really bad" have been found to not get immune.

That was straight from a government hearing today here in NL, those usually don't come with conveniently linked sources but at the same time they tend not to have bullshit in them.

Re: Promising Covid-19 treatment using convalescent serum therapy fast-tracked

#44
I really, really wish there could be a clear answer on at least this one basic thing that one would think (as a layman) to be fairly understood about viruses and immune response: Having had a SARS COVID 2 infection and assuming the virus hasn't mutated in the way that influenza does periodically to keep needing new vaccines, does or does not your body gain bloody immunity for some time after recovery? From everything I've know to date, the absolute normal, standard thing is that yes, being sick with something viral that doesn't cause your death gives you at least a certain period of months or usually years of immunity to it unless it mutates enough to re-attack without being recognized immediately. Is this not correct? For smallpox it applied, for chicken pox it does, for measles it mostly does for many years, likewise for many viruses for which there are vaccines. We even get immunity from the flu once we've had it for at least some months to a year or two. So why would Covid 2 be different?

Re: Promising Covid-19 treatment using convalescent serum therapy fast-tracked

#45

Earlier quoted context omitted.

I'm not referring the general concept. I've asked for a source that supported the claim that covid19 patients that "don't get it really bad" have been found to not get immune.

That was straight from a government hearing today here in NL, those usually don't come with conveniently linked sources but at the same time they tend not to have bullshit in them.

But do you have a source that backs up your baseless assertion? The world is tired of random guys online saying all type of nonsense and making all sorts of wild claims to then cower behind empty appeals to authority. I can just as easily claim that the pope said to me personally the exact opposite of what you're saying.

Re: Promising Covid-19 treatment using convalescent serum therapy fast-tracked

#46

I really, really wish there could be a clear answer on at least this one basic thing that one would think (as a layman) to be fairly understood about viruses and immune response: Having had a SARS COVID 2 infection and assuming the virus hasn't mutated in the way that influenza does periodically to keep needing new vaccines, does or does not your body gain bloody immunity for some time after recovery? From everything…

Short answer: recovering from Covid-19 probably does give immunity, based on all the precedents you mention, but we can't prove it for sure yet because not enough time has elapsed and no sufficiently rigorous studies have been done.

Of course viral antibodies persist for some amount of time, they don't disappear immediately upon clearing the virus. What we don't know is anything about the shape of that persistence. Is it days or weeks or years? Does it decline linearly, or exponentially (as a half-life), or on some other schedule? What kind of variance between people is there? How much does it vary based on all the other factors, like other health and immunological conditions, or re-exposure to the virus? This is all what we don't know yet, but need to before we can make assumptions regarding herd immunity to start lifting lockdowns.

Re: Promising Covid-19 treatment using convalescent serum therapy fast-tracked

#47

I read this last night: https://www.scmp.com/news/china/science/article/3078840/coro... It's not peer reviewed so might not be valid or entirely accurate but worrying nevertheless.

So, young people have way less antibodies. Lots of stats also show people aged 0-19 have barely any test-confirmed infetions compared to older populations. I also read that for the first 7 days, the virus mostly stays in your throat with mild symptoms and only after that it goes to the lungs causing major issues. Could it be that young people with strong immune systems easily fight the virus away within the first wee…

> for the first 7 days, the virus mostly stays in your throat with mild symptoms

I'm sorry but do you have a source for that? The only place I read this was in nonsensical WhatsApp forwards.

Re: Promising Covid-19 treatment using convalescent serum therapy fast-tracked

#48

I read this last night: https://www.scmp.com/news/china/science/article/3078840/coro... It's not peer reviewed so might not be valid or entirely accurate but worrying nevertheless.

So, young people have way less antibodies. Lots of stats also show people aged 0-19 have barely any test-confirmed infetions compared to older populations. I also read that for the first 7 days, the virus mostly stays in your throat with mild symptoms and only after that it goes to the lungs causing major issues. Could it be that young people with strong immune systems easily fight the virus away within the first wee…

Yes, I had something like this. Felt like a mild cold combined with altitude sickness. No cough.

Re: Promising Covid-19 treatment using convalescent serum therapy fast-tracked

#49

I read this last night: https://www.scmp.com/news/china/science/article/3078840/coro... It's not peer reviewed so might not be valid or entirely accurate but worrying nevertheless.

So, young people have way less antibodies. Lots of stats also show people aged 0-19 have barely any test-confirmed infetions compared to older populations. I also read that for the first 7 days, the virus mostly stays in your throat with mild symptoms and only after that it goes to the lungs causing major issues. Could it be that young people with strong immune systems easily fight the virus away within the first wee…

Out of my keister I'd assume young people's innate immune response might often defeat the virus on it's own. By the time the adaptive immune system kicks in the war is over.

Re: Promising Covid-19 treatment using convalescent serum therapy fast-tracked

#50

Earlier quoted context omitted.

So, young people have way less antibodies. Lots of stats also show people aged 0-19 have barely any test-confirmed infetions compared to older populations. I also read that for the first 7 days, the virus mostly stays in your throat with mild symptoms and only after that it goes to the lungs causing major issues. Could it be that young people with strong immune systems easily fight the virus away within the first wee…

Yes, I had something like this. Felt like a mild cold combined with altitude sickness. No cough.

Did the symptoms get worse and/or did you test positive for corona virus?
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