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Diabetes in mice cured rapidly using human stem cell strategy

medicine.wustl.edu

41–50 of 76 posts

Re: Diabetes in mice cured rapidly using human stem cell strategy

#41
post #3
post #2

Am I assuming correctly that this only applies for type 1 diabetes? With type 2 diabetes the body is in general less sensitive to insulin, more insulin producing cells won't fix the underlying insensitivity issue, right?

Isn't type 2 somewhat reversible by cleaning up diet and a prolonged fast?

>> prolonged fast

That can potentially kill a person with T2 through diabetic ketoacidosis(DKA). Please be careful if you refer this to someone else.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#42
post #8

Earlier quoted context omitted.

Not sure about a prolonged fast but I had my HbA1c levels at 6.8 (very much diabetic) once and by dropping sugar, white flour, white rice and potatoes and generally eating less (fasting is bad as far as I understand) every check I had since has been 5.3 (very much non-diabetic).

What's wrong with (intermittent) fasting? Of course if you don't raise your blood sugar as much by changing the diet, your HbA1c goes down by definition. However, limiting your feeding window will naturally reduce the amount of time you spend with elevated blood sugar, without any calorie reduction. Again, that'll lower your HbA1c by definition. Calorie reduction on the other hand can slow down metabolism and cause a…

https://www.medicalnewstoday.com/articles/321864

> New research suggests that intermittent fasting may raise insulin levels, damage pancreatic cells, and increase the amount of abdominal fat.

> Specifically, the new study — led by Ana Cláudia Munhoz Bonassa, a researcher at the University of São Paulo in Brazil — suggests that intermittent fasting may impair the normal activity of the pancreas and the production of insulin, which may, in turn, raise the risk of type 2 diabetes.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#43
post #42

Earlier quoted context omitted.

What's wrong with (intermittent) fasting? Of course if you don't raise your blood sugar as much by changing the diet, your HbA1c goes down by definition. However, limiting your feeding window will naturally reduce the amount of time you spend with elevated blood sugar, without any calorie reduction. Again, that'll lower your HbA1c by definition. Calorie reduction on the other hand can slow down metabolism and cause a…

https://www.medicalnewstoday.com/articles/321864 > New research suggests that intermittent fasting may raise insulin levels, damage pancreatic cells, and increase the amount of abdominal fat. > Specifically, the new study — led by Ana Cláudia Munhoz Bonassa, a researcher at the University of São Paulo in Brazil — suggests that intermittent fasting may impair the normal activity of the pancreas and the production of i…

Dr Nicola Guess, Lecturer in Nutritional Sciences at King’s College London, responding to that study:

> Firstly, it’s important to bear in mind there are important differences between rodents and humans – particularly with regard to diet. For example, a high fat diet causes insulin resistance in rats but it does not appear to in humans.

> The exact method is unclear from the abstract, but if the rats were fasted for one day, this is equivalent to an approximately 3 to 4 week fast in humans! So it’s not applicable to the 24-hour or 48-hour fasts practised by humans on common fasting diets.

(Note: the study made rats fast for 3 days)

Doesn't seem like the study I'd stop at when evaluating the benefits of intermittent fasting. For example, what about the promising ones that study actual humans and only see all markers improve?

I'd certainly stop going around spouting "fasting is bad" if this rat study is all you've got. Reminds me of that political cartoon of a soccer mom digging through a massive stack of studies, finally finding one that says vaccines might be bad, and going "Hah! Knew it!"

Re: Diabetes in mice cured rapidly using human stem cell strategy

#44
post #6
post #2

Am I assuming correctly that this only applies for type 1 diabetes? With type 2 diabetes the body is in general less sensitive to insulin, more insulin producing cells won't fix the underlying insensitivity issue, right?

T2D patients also have a reduced amount of insuline-producing beta cells. At diagnosis, there's been a 50% destruction of insuline-producing beta-cells. The destruction progresses with the disease.

I really wish the discussion on T2 would change - I'm tired of being blamed for being diabetic by medical professionals, I even lost a significant amount of weight (well over 100 lbs) but the diabetes returned.

In my case, my liver seems to emit a virtually endless amount of glucose, This is probably why I'm fat, and oddly, when my diabetes is well controlled, I'm never hungry, when its poorly controlled I'm hungry all the time and gain weight - which is how I was most of my life, being hungry virtually 24/7, even when my blood sugar was normal.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#45
post #3

Earlier quoted context omitted.

Isn't type 2 somewhat reversible by cleaning up diet and a prolonged fast?

>> prolonged fast That can potentially kill a person with T2 through diabetic ketoacidosis(DKA). Please be careful if you refer this to someone else.

T1 person, yes, but not T2, at least not with the T2 people I know.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#46
post #7

This reminds me of the time I spent at the NIH conducting research on cancer vaccines. After lots of trial and error, I had finally found something that seemed to prevent lung cancer in mice. I rushed to show my PI the results. He listened intently and asked thoughtful questions. Once I finished, I asked if the findings would be worthy of submitting to Nature. He looked me straight in the eye and said, “I wouldn’t pu…

I stopped counting how many times we cured any forms of diabetes in various mouse models. Then there is this thing that bugs me: amount of money spent on finding a treatment vs. preventing type 2 diabetes in the first place. Because 95% of type 2 cases are caused by life style decisions. And as climate change, healthcare costs, covid-19, and other self-inflicted societal crises we prefer to wait until it chronically…

> 95% of type 2 cases are caused by life style decisions

Do you have a source for that claim? My understanding is that genetics is the primary risk factor for diabetes.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#47
post #42

Earlier quoted context omitted.

https://www.medicalnewstoday.com/articles/321864 > New research suggests that intermittent fasting may raise insulin levels, damage pancreatic cells, and increase the amount of abdominal fat. > Specifically, the new study — led by Ana Cláudia Munhoz Bonassa, a researcher at the University of São Paulo in Brazil — suggests that intermittent fasting may impair the normal activity of the pancreas and the production of i…

Dr Nicola Guess, Lecturer in Nutritional Sciences at King’s College London, responding to that study: > Firstly, it’s important to bear in mind there are important differences between rodents and humans – particularly with regard to diet. For example, a high fat diet causes insulin resistance in rats but it does not appear to in humans. > The exact method is unclear from the abstract, but if the rats were fasted for…

I am very near 100% my attempts at intermittent fasting caused this blood sugar spike but since I do not have a lab result from before I can't prove it but I dislike coincidences like that.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#48

Earlier quoted context omitted.

Rice may be relatively high GI but it and similar foods do not usually give you type 2 diabetes. Junk food does. Rice is far cheaper than that. I don’t really think you can make the case that T2 diabetes is a poor man’s sickness.

White rice is linked with 10% increased chance of t2 with each serving per day(1). I don't know if poor Americans are doomed to diabetes, but it is certainly orders of magnitude easier for the poor to eat poorly compared to the rich. Boosting morale in the poor is difficult without cheap fatty/sweet food and drugs, other poor people have nearly nothing else to get by excessive stressors except exercise. Running a per…

I‘m pretty sure that that‘s a reverse causation. People who eat very high amounts of rice are the poor who can not afford a better mix of food. They are then malnourished as rice is not providing all needed nutrients. Also being poor means often no health care. Controlling for these socioeconomic factors is very difficult.

Rice in itself is a healthy food, especially when it is brown. I read a study some years ago where a doctor even cured mild forms of diabetes with high loads of rice instead of junk food. Don‘t have a link handy though.

Americans are not doomed to diabetes. Diabetes T2 is one of the easiest diseases to prevent. Vegans for example have 60-70% less diabetes according to observational studies like Adventist Health II.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#49
post #21

Earlier quoted context omitted.

It is true, the produce department has some of the cheapest food in the store. How much is a bundle of bananas? That's a week's breakfast. Unless you only buy organic, then you might go broke while hungry.

Bananas by themselves are not healthy food, they're very high in sugar and have little else to offer. Produce may look cheap, but if you add up the macros (and also some of the micros), it doesn't look cheap at all.

Bananas are high in potassium. And for a healthy individual fruit consumption has never been a problem. Please show me a study that fruit consumption is linked with higher rates of disease in healthy individuals.

Re: Diabetes in mice cured rapidly using human stem cell strategy

#50

Earlier quoted context omitted.

If you are well informed you could just cook once a week and eat that. I do that on the weekend with my family of five and it's quite a nice ritual. We cook rice and potatoes, put beans and sauce on top. And then put it in 20 containers for the week. I can prepare these meals within 2 minutes with a microwave. Breakfast is basically the same every day: Oat meal with some fruits. In the evening we eat bread with sprea…

Without any further context, this is most likely not a healthy diet. You're certainly missing out on B vitamins and heme iron due to lack of meat and likely have a poor Omega 6 to Omega 3 ratio due to the use of plant oils over other fats. Just a guess. You also probably get way too much sugar from sugary fruits which you overindulge in because your diet otherwise is so "healthy". Instead of soft drinks you have frui…

I did my research. Also I tracked my nutrition with Cronometer in the first weeks. Not a single day did I miss on B-vitamins.

Heme iron is associated with disease in all major studies. I don‘t see a reason to ingest it.

I have a great O3/O6 ratio. I don‘t use oil at all and avoid foods that are filled with plant oils. My breakfast contains lots of flax seeds. Our usual foods contain hemp seeds. All good sources of O3. And all without pollutants from fish.

I get a lot of information from nutritionfacts.org. Dr. Greger offers free information as in free beer. No ads, no sponsors, even the earnings from his books are given to charity. I highly recommend you check him out. He certainly has his biases but still way less than most other doctors.

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