Python has a lot of problems that really slow down development, but they are all fixable. The biggest issue, in my opinion, is in dependency management. Python has a horrible dependency management system, from top-to-bottom. Why do I need to make a "virtual environment" to have separate dependencies, and then source it my shell? Why do I need to manually add version numbers to a file? Why isn't there any builtin way…
Once your project is setup, dependency management is what you do once in two weeks perhaps. Rest is just writing code.