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Cannabidiol in Anxiety and Sleep: A Large Case Series

ncbi.nlm.nih.gov

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Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#41

Post by jaequery »

mettamage wrote: post #3

Why I post this: I am trying to sleep but can’t (on my phone to not wake anyone). I was wondering whether CBD might help. The study is simply a discussion prompt. My query also found [1]. I wonder who else has some insight into CBD. Edit: since this comment is quite down the discussion thread I would like to promote another topic [2]. It is about creating wearables that are able to measure stress. Measuring stress [2…

I’ve had chronic insomnia for over 3 years. The day I started CBD, was about 4 months ago. Right before that, my option was to try Ambien that I had to pry off from the doctors hands. I’ve not had the guts to try it after hearing it messes with your brain and causes you to have suicidal thoughts.

So I tried CBD after a quick research. First night, I didn’t feel a difference. I did feel a bit sleepier but I thought that was just my mind wanting to think that way. But after weeks of using it, I now can notice a calming effect that happens within 30 mins to an hour. And after I sleep, I wake up actually feeling refreshed. Some nights, I feel like I slept for days. It various night to night.

But compared to when I did not take CBd, I am sleeping way better now with cbd. I used to be on the fence about it’s effectiveness but the effects are so noticeable to me now that I’m incredibly thankful for CBD.

And for those that say just take a puff of the real thing, I never got a good night sleep with thc, I may get knocked out but I feel tired waking up. On the contrary, CBD actually increases your deep sleep cycle where as THC shortens it, similar to Ambien. This is a big factor you can’t ignore.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#42

Post by halbritt »

spectramax wrote: post #6

Stupid question but I’ve always wondered this - I hear Cannabis is used for anxiety relief but doesn’t smoking marijuana induce anxiety? Everyone I know who has smoked weed agrees with my experience - they’ve encountered some level of anxiety and paranoia. So, how exactly does weed help in reducing anxiety? Edit: Follow up question -> Is weed used to treat anxiety during the high or when you are normal (and have gene…

I've never been able to tolerate marijuana and have been around recreational users all my life. It's always caused me extreme anxiety. In the past year, I've experimented with various CBD products for chronic pain.

I've had mixed results for the pain, but the CBD definitely produces an anti-anxiety and a relaxing effect with none of the negative effects that I associate with marijuana, presumably with a great deal more THC.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#43

Post by TaylorAlexander »

spectramax wrote: post #6

Stupid question but I’ve always wondered this - I hear Cannabis is used for anxiety relief but doesn’t smoking marijuana induce anxiety? Everyone I know who has smoked weed agrees with my experience - they’ve encountered some level of anxiety and paranoia. So, how exactly does weed help in reducing anxiety? Edit: Follow up question -> Is weed used to treat anxiety during the high or when you are normal (and have gene…

A few personal anecdotes:

Sativa has a stronger anxiety producing effect for me than Indica if I remember correctly. I really only smoke sativa. That said, some sativa strains produce more anxiety than others. But when I do experience marijuana-induced anxiety, it tends to be very near the beginning of the high and subsides pretty quickly.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#44

Post by [deleted] »

spectramax wrote: post #6

Stupid question but I’ve always wondered this - I hear Cannabis is used for anxiety relief but doesn’t smoking marijuana induce anxiety? Everyone I know who has smoked weed agrees with my experience - they’ve encountered some level of anxiety and paranoia. So, how exactly does weed help in reducing anxiety? Edit: Follow up question -> Is weed used to treat anxiety during the high or when you are normal (and have gene…

[deleted]

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#45

Post by arkades »

jey wrote: post #2

This is a case series and literally has no control group. What's the background rate of people getting better without using CBD?

Importantly:

Inducing unconsciousness isn’t the same as sleep. Many chemicals that knock you on your ass also disrupt sleep architecture. A study that doesn’t at least throw a polysomnography on the patients to make a gesture in the direction of “they’re getting actual sleep” isn’t worth the paper it’s printed on.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#46

Post by TaylorAlexander »

duncan-donuts wrote: post #39
hrangozz wrote: post #28

Earlier quoted context omitted.

It wasn't until things were legalized that I had the option to try a 1:1 strain (equal ratio of CBD to THC) and I've found that to be a much better balance for me. The psychoactive aspects are still there, but less intense, more relaxing and without negative feelings. Kind of like sipping beer vs shooting tequila.

This is the most exciting thing about legalization to me. If I could go buy high cbd strains with a manageable level of thc I’d be first in line. I don’t want to get super high on thc. I just want all of the other effects.

They definitely sell 10:1 CBD:THC and 100% CBD in California. 100% CBD weed doesn’t even need to be sold at dispensaries. They sell that at lots of stores. My mom said the feed store has CBD oil for your pets.

Legalization is the best.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#47

Post by cwkoss »

hn_throwaway_99 wrote: post #23
spectramax wrote: post #6

Stupid question but I’ve always wondered this - I hear Cannabis is used for anxiety relief but doesn’t smoking marijuana induce anxiety? Everyone I know who has smoked weed agrees with my experience - they’ve encountered some level of anxiety and paranoia. So, how exactly does weed help in reducing anxiety? Edit: Follow up question -> Is weed used to treat anxiety during the high or when you are normal (and have gene…

In my experience, if I smoke a very small amount of weed (like literally one hit) it can relax me and make me less anxious. It slows things down, and can just generally numb some of my underlying anxieties. However, it doesn't take much for me to cross that threshold where it can make me extremely paranoid. Usually this is what I call the "will I be stuck this way forever" threshold, where I get stoned to the point w…

This comment made me curious and I did some googling for studies on the anxiogenic (anxiety-increasing) effects of THC. Some interesting resuts:

THC's anxiety inducing effects are (at least in part) caused by CB! receptor activity in the right amygdala. "Fourteen healthy males were studied with fMRI twice, one month apart, following an oral dose of either delta-9-THC (10 mg) or placebo, while they performed a fear-processing task. Baseline availability of the CB1 receptor was studied using PET with [11C]MePPEP, a CB1 inverse agonist radioligand. Relative to the placebo condition, delta-9-THC induced anxiety and modulated right amygdala activation while processing fear. Both these effects were positively correlated with CB1 receptor availability in the right amygdala. These results suggest that the acute effects of cannabis on anxiety in males are mediated by the modulation of amygdalar function by delta-9-THC and the extent of these effects are related to local availability of CB1 receptors." https://www.nature.com/articles/s41598-017-14203-4

Would be interested to study if there is a difference in fear response in sober thc users and non-users. Does 'tolerance' of THC entail amygdalar CB1 downregulation? Does this have measurable effects besides intoxication-related anxiety?

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Anxiogenic effects in rats are greater in adults than adolescents https://www.ncbi.nlm.nih.gov/pubmed/17211649

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"Guiaol, eucalyptol, γ-terpinene, α-phellandrene, 3-carene, and sabinene hydrate all have significant correlations with decreased anxiolytic activity." (Certain strains may have constituents which increase anxiety - many of these have distinctive smells) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6204402/

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CBD is widely regarded as safe - this study raises some concern. Could chronic CBD use could possible cause upregulation of amygdalar CB1?

Anxiogenic-like effects of chronic cannabidiol administration in rats https://www.researchgate.net/publication/51798464_Anxiogenic...

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#49

Post by swest »

mettamage wrote: post #3

Why I post this: I am trying to sleep but can’t (on my phone to not wake anyone). I was wondering whether CBD might help. The study is simply a discussion prompt. My query also found [1]. I wonder who else has some insight into CBD. Edit: since this comment is quite down the discussion thread I would like to promote another topic [2]. It is about creating wearables that are able to measure stress. Measuring stress [2…

This is definitely anecdotal, but I also have a hard time getting to sleep. I tried CBD just on a whim to see if how it would affect me. I didn't really read up on it's affects, I was just curious. The only thing I noticed was when I laid in bed at night, I fell asleep super quickly.

Re: Cannabidiol in Anxiety and Sleep: A Large Case Series

#50

Post by gnulinux »

colordrops wrote: post #22
spectramax wrote: post #6

Stupid question but I’ve always wondered this - I hear Cannabis is used for anxiety relief but doesn’t smoking marijuana induce anxiety? Everyone I know who has smoked weed agrees with my experience - they’ve encountered some level of anxiety and paranoia. So, how exactly does weed help in reducing anxiety? Edit: Follow up question -> Is weed used to treat anxiety during the high or when you are normal (and have gene…

As others have mentioned, it's the THC component that can cause anxiety. I have high anxiety and THC usually makes it worse, but that's just temporary. I find that THC is bringing subconscious worries and pains to the surface, and if I actively process them, then I come out of the high feeling extreme relaxation and peace, more than I ever got from pure CBD.

Just a data point. I dealt with anxiety my entire life, and too much weed absolutely destroys me but small amount of weed definitely calms me down. When I smoke too much weed, it really doesn't feel like my anxieties deep down are surfaces. It feels like my brain is making up new stupid things. To me, weed is a very strong sensory experience. When I'm too high it almost feels I'm hearing too much, feeling too much, seeing too much and that disorients me. Also due to my anxiety I've dealt with dp/dr in the past (luckily I don't have this problem any more) and too much weed induces this dp/dr back.

When I was young and stupid I did get too high and got bitten by it. One needs to learn lessons the hard way. You need to be respectful to drugs, try understand the science behind how substances affect your brain and start small and increase doses infinitesimally as you feel comfortable and as you decide it does not affect your life negatively in any way objectively.

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