Earlier quoted context omitted.
How do you manage keeping all the keys "synced" in terms of which services they are registered with. I keep keys in separate locations for safety, but that makes adding all keys to a new account a big pain. This hasn't been a big problem yet because there are so few services that support the keys, but I wonder how people would manage it if it became widespread.
For U2F there's nothing to be in sync: each key is added individually, and you don't have to add all of them at once. I.e. if you register the key on your keychain at work, you could later add the backup key in your home vault. For storing TOTP keys on your YubiKeys, those must be the same, so you probably have to add them at the same time, or take a picture of the QR-code before you complete the registration.
The challenge is remembering to enroll using your backup device. Also, ideally your 2 devices would never be in the same room as each other, otherwise you are at risk of something like a fire destroying both.