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Inflammation might be the root of preventable disease

harvardmagazine.com

41–50 of 240 posts

Re: Inflammation might be the root of preventable disease

#41

At the same time, anti-inflammatories slow wound healing. Here are a couple of random studies I found. https://www.ncbi.nlm.nih.gov/pubmed/17319622 https://www.ncbi.nlm.nih.gov/pubmed/22381097

Yup, and anti-oxidants actually prevent aerobic conditioning in athletes.[1]. Presumably oxidative stress is a signal to the body to become more aerobically efficient.

Yet at the same time, oxidative stress is linked to numerous diseases.

Biology is hard.

[1] Derek Lowe’s blog (don’t have exact link)

Re: Inflammation might be the root of preventable disease

#43

How can a symptom be the "cause" of a disease? Gingivitis is "inflammation of the gums", but it's "caused" by bacteria, plaque, tarter, etc... inflammation is the description of what is happening (ie, symptom) not the "cause".

Inflammation is not just a symptom, but also an underlying process.

Lots of things can cause inflammation, but the underlying process can be similar. And it can have good and bad effects.

Re: Inflammation might be the root of preventable disease

#44
post #15

Earlier quoted context omitted.

I did. In fact that was a great start, but once you reach a certain point (in having metabolic syndrome), the Keto+IF reaches diminishing returns. It did bring me down 18 inches on the waist. The gut and hypertension will remain. In fact, my hypertension actually went up. To go further requires either Metformin or Berberine. I opted for Berberine, but time will tell.

Awesome that it worked so well for you while it did. Tip for others who may try this: don't forget to lower your macros (and, in turn, calories) an appropriate amount as your weight drops. The same diet that maintains keto at 250 lbs won't keep you in keto at 190. For much, much more: https://peterattiamd.com/

Keto is the absence of carbs. So the same diet that maintains keto at 250 will keep you in keto at 190, since it is what you eat, not how much you are eating. But you are absolutely correct that one must change their caloric intake as they lose weight if they want to keep losing weight.

Re: Inflammation might be the root of preventable disease

#46
post #41

At the same time, anti-inflammatories slow wound healing. Here are a couple of random studies I found. https://www.ncbi.nlm.nih.gov/pubmed/17319622 https://www.ncbi.nlm.nih.gov/pubmed/22381097

Yup, and anti-oxidants actually prevent aerobic conditioning in athletes.[1]. Presumably oxidative stress is a signal to the body to become more aerobically efficient. Yet at the same time, oxidative stress is linked to numerous diseases. Biology is hard. [1] Derek Lowe’s blog (don’t have exact link)

It's almost as-if our cells depend on some sort of chemical equilibrium. The old advice of everything in moderation may be the best way to go.

Re: Inflammation might be the root of preventable disease

#47
post #41

At the same time, anti-inflammatories slow wound healing. Here are a couple of random studies I found. https://www.ncbi.nlm.nih.gov/pubmed/17319622 https://www.ncbi.nlm.nih.gov/pubmed/22381097

Yup, and anti-oxidants actually prevent aerobic conditioning in athletes.[1]. Presumably oxidative stress is a signal to the body to become more aerobically efficient. Yet at the same time, oxidative stress is linked to numerous diseases. Biology is hard. [1] Derek Lowe’s blog (don’t have exact link)

"Biology is hard" doesn't really express what I think people don't get about biology (granted I'm not a biologist).

With everything complex, not just living creatures, the real problems are caused by failure to maintain a negative feedback loop properly, and pushing on it doesn't help because the negative feedback is still there almost the same way as normal and has to be to avert complete disaster.

Re: Inflammation might be the root of preventable disease

#48
post #19

At the same time, anti-inflammatories slow wound healing. Here are a couple of random studies I found. https://www.ncbi.nlm.nih.gov/pubmed/17319622 https://www.ncbi.nlm.nih.gov/pubmed/22381097

Something I experienced about 20 years ago - I threw my back out (just was sitting, and turned my torso - and that was it), major sciatica pain. Went to the doctor. I was prescribed a certain stretching exercise, plus also 800mg ibuprofen, bed rest, etc. I was popping the ibuprofen "on schedule" - 3x a day. At first, it helped some, and so did the exercise. But then, the pain came back, and nothing was cutting it. No…

Anecdotally, my own experience with chronic back issues is the reverse, and jives with the explanation I was given. My lowest 3 disks are degenerating, with the bottom disk almost gone. About 8 years ago I had to have a laminectomy due to a disk bulge pushing against a nerve, and no amount of NSAIDs nor physical therapy would fix it.

I had herniated disks before and after, but only one required surgery. For as long as I can remember, I'll get severe back pain once or twice a year, which eventually goes away. The explanation I received for these events is that it is likely that the outer sheath of a disk is getting torn, stretched, or some other type of trauma. This hurts in and of itself, however, additionally the disk material may begin to bulge. Once bulging, that part of the disk loses access to nutrients and moisture and eventually dries up, with the bulge receding and the damage scarring over. The doctor described this like a grape to a raisin, though I'm sure it looks nothing like the analogy.

Summary, with time, the disk sheathing trauma scars and the bulge dessicates, possibly about the same time NSAIDs are declared of no help.

For me, I definitely notice much less pressure in my back when on an NSAID, and I sleep much better as well.

Re: Inflammation might be the root of preventable disease

#49
post #19

At the same time, anti-inflammatories slow wound healing. Here are a couple of random studies I found. https://www.ncbi.nlm.nih.gov/pubmed/17319622 https://www.ncbi.nlm.nih.gov/pubmed/22381097

Something I experienced about 20 years ago - I threw my back out (just was sitting, and turned my torso - and that was it), major sciatica pain. Went to the doctor. I was prescribed a certain stretching exercise, plus also 800mg ibuprofen, bed rest, etc. I was popping the ibuprofen "on schedule" - 3x a day. At first, it helped some, and so did the exercise. But then, the pain came back, and nothing was cutting it. No…

Inflammation can be a signal to the body to heal an area specifically expressing the inflammation. Many treatments involve causing additional damage to the wounded area to promote inflamation. This is good!

Its chronic inflammation that's not good.

Re: Inflammation might be the root of preventable disease

#50
post #24
post #19

Earlier quoted context omitted.

Something I experienced about 20 years ago - I threw my back out (just was sitting, and turned my torso - and that was it), major sciatica pain. Went to the doctor. I was prescribed a certain stretching exercise, plus also 800mg ibuprofen, bed rest, etc. I was popping the ibuprofen "on schedule" - 3x a day. At first, it helped some, and so did the exercise. But then, the pain came back, and nothing was cutting it. No…

I can’t find the citation right now, but as I recall, a lot of connective tissue has very little blood flow. Inflammation increases blood flow, which can help with healing.

Achilles tendinosis is a good example of this. The achilles tendon replaces cells at a very slow rate. If there is chronic damage, it can take decades to heal on its own. But if you intentionally damage the area with eccentric heel drops, it can heal fairly quickly.
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