Flashing Light, Sound Restore Memory in Alzheimer's Mice • Hacker News Board

Re: Flashing Light, Sound Restore Memory in Alzheimer's Mice

#41

Post by louthy » Thu, Mar 21, 2019, 2:30 PM UTC

SubiculumCode wrote: post #35

louthy wrote: post #13

Earlier quoted context omitted.

[3] is definitely not 40hz. 40hz is in the sub-bass range, which this clearly isn't. I'm not at home in my studio right now, so I can't measure what it is, but if I was to guess it would be around 200hz. The ones that are 20hz might make you feel a bit weird because there's not much amateur audio equipment that would do anything other than distort at that low end of the frequency range. It does say binaural though, s…

In the paper, "a 10 kHz tone was played at 40 Hz" So its a high pitched sound played in 40 Hz bursts. Anyone have a generator for something like that? (though 10 kHz can be annoying)

Seems weird that the second value (40) is in Hz. It doesn't specify the duration of the burst, if it is in bursts. Is it once cycle of a 10 KHz tone 40 times a second, or more? Very odd.

Re: Flashing Light, Sound Restore Memory in Alzheimer's Mice

#42

Post by mattkrause » Thu, Mar 21, 2019, 2:32 PM UTC

existencebox wrote: post #27

josephby wrote: post #9

Mice clap don’t clap get clap Alzheimer’s. They have neural plaques, artificially, chemically induced, that are coincident with Alzheimer’s in humans.

I don't know why this is being downvoted as much as it is. Wife works in a related field of neuro-sci, and regularly laments this difference, especially how it's played up in both in reporting and in assuming consistency in treatment and response. To the best of my knowledge there's not even consensus that plaques are the "root cause" we should be focusing on, so this sort of model may be multiple steps removed from…

> plaques are the "root cause

The amyloid hypothesis has been pretty popular for ~25 years, and it's pretty clear that the plaques have something to do with Alzheimers, but it's been a absolute disaster as a treatment target. It feels very much like treating a fever by slathering the patient in antiperspirant.

Biogen announced this morning that they're giving up on Phase III trials of aducanumab, an antibody that was supposed to target and remove the plaques (their stock is doing...badly as a result). https://www.reuters.com/article/us-biogen-alzheimers/biogen-...

There were two other big failures last year here too, as this nice little Nature News piece describes: https://www.nature.com/articles/d41586-018-05719-4

Re: Flashing Light, Sound Restore Memory in Alzheimer's Mice

#43

Post by fao_ » Thu, Mar 21, 2019, 7:59 PM UTC

mattkrause wrote: post #34

fao_ wrote: post #33

Earlier quoted context omitted.

Nature is hardly the top of the crust these days with regards to academic oversight. I can recall quite easily that a while back they published an article confirming ESP, and then refused to publish a replication of the same paper stating no results. Because the first one sells issues and the second one doesn't.

Nature does love flashy stories but the ESP stuff wasn’t them, it was JPSP. Here’s the citation: Bem, D. J. (2011). Feeling the future: Experimental evidence for anomalous retroactive influences on cognition and affect. Journal of Personality and Social Psychology, 100(3), 407-425. http://dx.doi.org/10.1037/a0021524 Nature did publish a thing on “water memory” in the 1980s. To their (partial) credit, it was published…

Thank you for the correction! :)