41–50 of 133 posts
Does this line of inquiry mesh at all with the idea that "Gum disease–causing bacteria could spur Alzheimer’s" Or are they competing hypotheses? reported here in January: https://news.ycombinator.com/item?id=18987015
Earlier quoted context omitted.
Source?
https://thejns.org/abstract/journals/j-neurosurg/113/3/artic...
I would like to see how the prevalence of Alzheimer's among Neurosurgeons compares against a population with similar work/sleep schedules (eg. finance)
Earlier quoted context omitted.
What eye exam(s) involve physical contact between the eyeball and a medical instrument? Or did a joke just go sailing over my head?
Checking eye pressure involves an instrument touching the eye, and is pretty routine.
Dumb question (Wikipedia was of no help), if amyloid beta looks and acts like a prion, why isn't it classified as a prion?
>"Some amyloid proteins are infectious; these are called prions in which the infectious form can act as a template to convert other non-infectious proteins into infectious form." https://en.wikipedia.org/wiki/Amyloid
So if amyloid-beta is determined to be "infectious" (however that is done) then it would be put in the prion subclass of amyloids.
Does this line of inquiry mesh at all with the idea that "Gum disease–causing bacteria could spur Alzheimer’s" Or are they competing hypotheses? reported here in January: https://news.ycombinator.com/item?id=18987015
Earlier quoted context omitted.
https://thejns.org/abstract/journals/j-neurosurg/113/3/artic...
A possible explanation could be based on research suggesting that regular lack of deep sleep increases risk of Alzheimer’s. Given that Neurosurgeons have a grueling 7-8? year residency period after medical school, it would be possible that they undersleep far more than the control group. I would like to see how the prevalence of Alzheimer's among Neurosurgeons compares against a population with similar work/sleep sch…
They are the most thermodynamically stable structure that polypeptides can form, and require constant housekeeping to prevent. Accumulation of amyloids is like failing to taking out the trash in your house.
Afaik, there has never been a disease state checked for amyloids that failed to be associated with them (heart disease, cancer, stroke, etc).
>"From a wide range of in vitro experiments on peptides and proteins we now know that the formation of amyloid structures is not a rare phenomenon associated with a small number of diseases but rather that it reflects a well-defined structural form of the protein that is an alternative to the native state — a form that may in principle be adopted by many, if not all, polypeptide sequences
[...]
These observations, therefore, have led to the remarkable conclusion that, at the concentrations present in living systems, the native states may not always represent the absolute free energy minima of the corresponding polypeptide chains — the native form of a protein could in some cases simply be a metastable monomeric (or functionally oligomeric) state that is separated from its polymeric amyloid form by high kinetic barriers" http://www.ncbi.nlm.nih.gov/pubmed/24854788
I've previously commented the same thing:
https://news.ycombinator.com/item?id=14914528#14917057
https://hn.algolia.com/?query=amyloid%20nonbel&sort=byPopula...
The more we study the human body, the more questions we get. I wonder if some future Dr. McCoy centuries from now will we us as we do medicine of two centuries ago. We can go to other planets and invent new tech every day, but the body still holds a ton of mysteries.
Earlier quoted context omitted.
A possible explanation could be based on research suggesting that regular lack of deep sleep increases risk of Alzheimer’s. Given that Neurosurgeons have a grueling 7-8? year residency period after medical school, it would be possible that they undersleep far more than the control group. I would like to see how the prevalence of Alzheimer's among Neurosurgeons compares against a population with similar work/sleep sch…
Do they ever stop? What does a surgeon do in their free time?
[1] https://www.eventbrite.com/e/ieee-buenaventura-embs-talk-fig...
[2] https://biologydirect.biomedcentral.com/articles/10.1186/174...