If your website relies on JavaScript to work, then you're excluding people who can't use JavaScript. Disabled people with screen readers. If you don't cater for those people, put some money aside for lawyers.
I've found that one of the major complaints that blind users have is that it's a total bitch to work with dynamically updating pages. If more developers paid attention to web accessibility, a lot of the major problems to disabled folks would be greatly alleviated.
http://en.wikipedia.org/wiki/Web_Accessibility_Initiative http://en.wikipedia.org/wiki/Web_Content_Accessibility_Guide... http://en.wikipedia.org/wiki/Section_508_Amendment_to_the_Re...
I say this as a visually impaired developer with several blind friends and family. To me, web accessibility is serious business.