There was a good chunk of time where my ISP (Verizon FIOS at the time) was having some kind of DNS hijacking attack happening where many CDN IPs were being replaced with an IP of a server that was adding some ad-injecting javascript into many pages (and god knows what else, I still have the payload laying around somewhere as I saved it for future curiosity). At the time my only real recourse was to pump my whole hous…
A similar setup to mine could be deployed at your network edge, and it could then force all of your port 53 DNS requests to go over a more secure protocol. Of course you would have to figure out how to set this up, and it wouldn't protect your devices anywhere except your home network.