Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Nicotinamide riboside effects on aging similar to caloric restriction

colorado.edu

Post reply on HN
Print view View original

41–50 of 86 posts

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#41

Post by truculation »

e9 wrote: post #35
deegles wrote: post #20

Does anyone know where to get it in bulk form? The commercial stuff I've seen seems way overpriced. Also, I'm happy for the disclosure but be wary of potential bias... > The study was partially funded by grants from the National Institutes of Health and the American Federation for Aging Research. ChromaDex, the maker of NIAGEN provided supplements and some financial support.

Just use high quality niacin/nicotinic acid/vitamin-b3. "niacin supplementation increases cellular nicotinamide adenine dinucleotide (NAD+) levels" reference: https://examine.com/supplements/vitamin-b3/

Yes and be prepared for that 'niacin flush' if you take a 500mg capsule the first time. Phew. I had to lie down for half an hour.

https://niacinreviews.com/niacin-max-flush/

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#43

Post by delbel »

p0wn wrote: post #30
deegles wrote: post #20

Does anyone know where to get it in bulk form? The commercial stuff I've seen seems way overpriced. Also, I'm happy for the disclosure but be wary of potential bias... > The study was partially funded by grants from the National Institutes of Health and the American Federation for Aging Research. ChromaDex, the maker of NIAGEN provided supplements and some financial support.

As far as I know it's fairly hard to synthesize, and isn't produced in large quantities yet.

Smoking cigarettes would do it. Nicotine + Oxygen right? Who knew the movie Sleeper had it right, keto diet and tabacco. https://www.youtube.com/watch?v=D2fYguIX17Q

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#44

Post by vondur »

reasonattlm wrote: post #36
deegles wrote: post #20

Does anyone know where to get it in bulk form? The commercial stuff I've seen seems way overpriced. Also, I'm happy for the disclosure but be wary of potential bias... > The study was partially funded by grants from the National Institutes of Health and the American Federation for Aging Research. ChromaDex, the maker of NIAGEN provided supplements and some financial support.

There are any number of suppliers other than the sole sanctioned one. Search Alibaba. Assume you will pay a fraction of what you'd pay the sanctioned suppliers, but you will also have to run a sample via a LC-MS analysis to see that you are in fact getting what you think you are getting. This is all pretty easy to arrange, and works for just about any well known compound, peptide, etc. If you are willing to do that,…

I don't think the average person has access to a Mass Spec or Liquid Chromatography equipment.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#46

Post by scarhill »

Confusion wrote: post #37
oakwhiz wrote: post #5

Earlier quoted context omitted.

>how often did i read a piece of journalism outside my area of expertise with equally lazy mistakes, without noticing them? This is often referred to as the "Gell-Mann Amnesia Effect": "Briefly stated, the Gell-Mann Amnesia effect works as follows. You open the newspaper to an article on some subject you know well. In Murray’s case, physics. In mine, show business. You read the article and see the journalist has abso…

Which should of course not be exaggerated and fully blamed on the reporter. A reporter not understanding what a physicist explained does not mean they lack the ability to understand what a policeman or politician told them. A reporter not being able to explain a theory does not mean they cannot correctly report on the plain facts of a murder or a policy proposal. In such cases the risks are inferences drawn from the…

Except it's not just complex scientific subjects they get wrong. If you start looking for it you'll find it's anything that you know about. I've observed it in articles on pigeon racing.

Here's the source for the Gell-Mann Amnesia Effect quote: https://web.archive.org/web/20061020012137/http://www.cricht...

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#47

Post by reasonattlm »

vondur wrote: post #44
reasonattlm wrote: post #36

Earlier quoted context omitted.

There are any number of suppliers other than the sole sanctioned one. Search Alibaba. Assume you will pay a fraction of what you'd pay the sanctioned suppliers, but you will also have to run a sample via a LC-MS analysis to see that you are in fact getting what you think you are getting. This is all pretty easy to arrange, and works for just about any well known compound, peptide, etc. If you are willing to do that,…

I don't think the average person has access to a Mass Spec or Liquid Chromatography equipment.

https://www.scienceexchange.com

$100-150 to run a sample through LC-MS via any one of dozens of small laboratory groups. Most are willing to explain things to a newcomer who is working his or her way through learning the ropes.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#48

Post by dmix »

JoshMnem wrote: post #38

I think calorie restriction is a more interesting idea, because it forces you to think about eating high-nutrient foods. The first things I did were to eliminate sugars and other processed ingredients, including all flours. Continuing to eat junk and assuming that pills and supplements will compensate for that is probably not a good idea.

From the article:

> From a public health perspective [restricting calories] would be impractical for many and dangerous for some.

Regardless of what's the most optimal solution it's very helpful to have the option when this isn't an easy/practical option. And having tried to cut out sugars and processed foods in my own life, it was certainly not easy and required a significant monetary and time investment to cook my own meals, and buy fast-expiring produce.

It doesn't have to be either/or to reach health goals, as you can mix the two depending on your particular resources.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#49

Post by TheSpiceIsLife »

reasonattlm wrote: post #47
vondur wrote: post #44

Earlier quoted context omitted.

I don't think the average person has access to a Mass Spec or Liquid Chromatography equipment.

https://www.scienceexchange.com $100-150 to run a sample through LC-MS via any one of dozens of small laboratory groups. Most are willing to explain things to a newcomer who is working his or her way through learning the ropes.

I'm often either:

a) surprised that processes that seemed futuristic or industrial are available to the average person at a reasonable price

or

b) surprised that others are surprised

I operate a 4kW laser cutter set up to cut metal. Once new customers realise how much product the machine can put out in an hour they understand that it isn't an expensive service, and that it is in fact almost always cheaper to have an item laser cut rather than do it themselves using any of the tools they have in their workshop.

Re: Nicotinamide riboside effects on aging similar to caloric restriction

#50

Post by VoiceOfWisdom »

truculation wrote: post #41
e9 wrote: post #35

Earlier quoted context omitted.

Just use high quality niacin/nicotinic acid/vitamin-b3. "niacin supplementation increases cellular nicotinamide adenine dinucleotide (NAD+) levels" reference: https://examine.com/supplements/vitamin-b3/

Yes and be prepared for that 'niacin flush' if you take a 500mg capsule the first time. Phew. I had to lie down for half an hour. https://niacinreviews.com/niacin-max-flush/

Beware the niacin flush. Once I took 500mg, after having already been accustomed to the flush. It hit hard that day though. 15 minutes after taking the pill, while driving, my vision started to narrow and go black. It felt like being chocked out. I was rapidly losing consciousness, but was able to safely pull over to the side of the road. Before completely passing out I was able to vomit up what was left of the pill. I was able to return home, and sleep for the rest of the day. This was with a single 500mg pill, after already being used to the flush.
Post reply on HN