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Increased acidity found in schizophrenia and bipolar patients’ brains

scientificamerican.com

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Re: Increased acidity found in schizophrenia and bipolar patients’ brains

#41
post #34

> "A main source of these temporary surges is the carbon dioxide that is constantly released as the brain breaks > down sugar to generate energy, which subsequently turns into acid." The "Ketosis" / "Ketogenic diets" are helping in this case? https://en.wikipedia.org/wiki/Ketosis https://en.wikipedia.org/wiki/Ketogenic_diet

Go look up Dr Dom D'agostino's work on using "medical keto" (as in, 4:1 ratio (in grams) of fat to carbs+protein, while keeping carbs at below 30g and enough protein to maintain muscle) to control epilepsy in drug resistant patients.

That kind of answers your question, but not directly.

Re: Increased acidity found in schizophrenia and bipolar patients’ brains

#43
post #32

My medical condition makes the body too acidic. This is a well known thing. Doctors know it. Patients know it. Yet, it is not treated as a primary issue. It only gets treated secondarily to help control specific developments, like acid reflux. I have known a number of bipolar people and I tend to easily click with them. I don't think I am actually bipolar, but I do suspect my medical condition sometimes impacts my br…

Great analogy.

Re: Increased acidity found in schizophrenia and bipolar patients’ brains

#44
post #25

This reminds me of research from a while back suggesting schizophrenia was related to an ancient retrovirus that entered our DNA millions of years ago and occasionally causes problems (Discover mag, "The Insanity Virus," June 2010). Reseach is ongoing: ( http://discovermagazine.com/2015/sept/6-insanity-virus ). From the 2010 story: > Sixty million years ago, a lemurlike animal—an early ancestor of humans and monkeys—…

> It may not have made the lemur ill I've often wondered how many viruses we contract that don't present any obvious symptoms. How would we know to look for them? Does anyone know if this idea has been looked in to?

There would be no way to answer that question with our current technology.

Even the idea of contracting a virus is not well defined. Does it have to reproduce from human cells? What if it just passes through us or lives off our gut bacteria?

The whole world is soaked with viruses. They're everywhere all the time and if they don't specifically interfere with us we never notice 'em.

Re: Increased acidity found in schizophrenia and bipolar patients’ brains

#45
post #24

> Other research has revealed that the brains of people with panic disorders produce elevated levels of lactate—an acidic source of fuel that is constantly produced and consumed in the energy-hungry brain. For me, this further confirms that metabolic problems are causally-associated with 'mental disorders'. Lactic acidosis is a medical condition characterized by the buildup of lactate (especially L-lactate) in the bo…

What's the test?

This page has a write up about folate & mental health:

https://www.psychologytoday.com/blog/the-integrationist/2014...

Re: Increased acidity found in schizophrenia and bipolar patients’ brains

#46
post #32

My medical condition makes the body too acidic. This is a well known thing. Doctors know it. Patients know it. Yet, it is not treated as a primary issue. It only gets treated secondarily to help control specific developments, like acid reflux. I have known a number of bipolar people and I tend to easily click with them. I don't think I am actually bipolar, but I do suspect my medical condition sometimes impacts my br…

Interesting analogy but it doesn't always hold. Take the greening of Ascension Island [1] where planting trees created a virtuous cycle: the trees trapped more moisture which promoted the growth of more trees.

In biology there are many complicated feedback loops and in some cases a parameter seems to get stuck outside of the normal range. In those cases, bringing the parameter back into the normal range can be enough to allow the normal feedback mechanisms to work properly again.

Some examples:

* Eczema: There can be a loop between irritation, inflammation, damage to the skin, more irritation. Treat the skin with steroids to both improve symptoms and disrupt the loop.

* Myopia: Studies have shown that undercorrecting for near-sightedness actually makes it worse [2]. Bringing it back into the normal range doesn't just help the symptoms, it also makes it progress slower.

* Depression: Maybe operating at a higher level, but there's a clear loop between changed behaviour and improved motivation.

Even something like acidity could be like this. You could speculate a link between gut bacteria and acidity, whereby changing the acidity directly could alter the balance of bacteria which locks in the change in acidity.

[1] http://faculty.washington.edu/dcatling/Catling2012_GreenMoun...

[2] http://www.journalofoptometry.org/en/under-correction-human-...

Re: Increased acidity found in schizophrenia and bipolar patients’ brains

#47
post #32

My medical condition makes the body too acidic. This is a well known thing. Doctors know it. Patients know it. Yet, it is not treated as a primary issue. It only gets treated secondarily to help control specific developments, like acid reflux. I have known a number of bipolar people and I tend to easily click with them. I don't think I am actually bipolar, but I do suspect my medical condition sometimes impacts my br…

Interesting analogy but it doesn't always hold. Take the greening of Ascension Island [1] where planting trees created a virtuous cycle: the trees trapped more moisture which promoted the growth of more trees. In biology there are many complicated feedback loops and in some cases a parameter seems to get stuck outside of the normal range. In those cases, bringing the parameter back into the normal range can be enough…

I am aware that the existence of trees tends to promote rain, so, no, it isn't an absolute, black or white thing.

My medical condition is genetic in origin. I have reversed a lot of my symptoms and, yes, maintaining my improved condition is easier than I expected.

I have come to believe that "the normal progression" of my condition is rooted in a nasty positive feedback loop. If you can interrupt it, it is game changing.

But interrupting it isn't for sissies, so to speak.

Even so, my body will never be normal. But it is sort of like being a Kosher Jew: As long as I abide by particular dietary and lifestyle restrictions, I don't have to be sick all the time, even though it means I can't live "normally." I am happy to accept that deal over the alternative.

Re: Increased acidity found in schizophrenia and bipolar patients’ brains

#48
post #6

Earlier quoted context omitted.

That the pH is lower has apparently been known for a while. What's not been clear is the cause of the lower pH and whether the low pH is causing the disorders or if it's just a side effect of an underlying cause or of the medications. This still isn't clear. It could even be a combination of factors, with low pH caused by lactate production stimulating the disorder which increases lactate production... etc.

IMO one aspect that isn't well understood enough, and not given enough emphasis in research, are the "cleaning" cycles of the brain. In particular, neuronal autophagy, but also cleaning cycles during sleep. If the overall PH is off, something isn't being cleaned correctly. A byproduct isn't being removed. I'd love to know how a ten day water fast affects the mental processing and bio-markers of a group of schizophren…

Ten day water fast sounds like a great way to die of a starvation-induced heart attack.

What is the significance behind ten days of starvation? Why not 1 or 2 or 3? 10 sounds 100% arbitrary.

Re: Increased acidity found in schizophrenia and bipolar patients’ brains

#49
Two words: Buteyko method

See e.g. http://www.normalbreathing.com

CNS/Diseases of the Brain Are Caused by Low Brain O2/CO2 Levels

http://www.normalbreathing.com/diseases-Brain.php

Sedatives | CO2: Natural Sedative and Tranquilizer http://www.normalbreathing.com/CO2-stabilizer.php

After 15 years of panic attacks, anxiety, migraines, hay fever... if finally found the solution: learn to breathe correctly again. The best and cheapest thing I've ever learned for my health!

This is just one site, but there are many more on the web. Not affiliated to a single one of them, but hopefully I can share the joy of a panic attack free live with at least one other person. :)

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