Earlier quoted context omitted.
There's rarely an antibody that kills every possible strain of a disease, illustrated by the fact that there is not an antibody that kills every disease . 91% of HIV strains means we are 91% of the way to complete eradication. Plus, one of the big problems thus far have been we had NO IDEA how to attack the HIV bodies. Perhaps developing an understanding of this antibody will allow us to gain new understanding, and p…
91% of HIV strains means we are 91% of the way to complete eradication. That is inaccurate. Current antiviral agents remove most (as in over 90%) of the HIV viral particles from the blood of a patient. But then after weeks or months the viral load in blood is just as high. And any given patient has numerous strains within. Furthermore, most viral particles are not active: the virus saturates the immune system with de…
Antibody Kills 91% of HIV Strains
41–50 of 54 posts
Re: Antibody Kills 91% of HIV Strains
#42Re: Antibody Kills 91% of HIV Strains
#43Earlier quoted context omitted.
91% of HIV strains means we are 91% of the way to complete eradication. That is inaccurate. Current antiviral agents remove most (as in over 90%) of the HIV viral particles from the blood of a patient. But then after weeks or months the viral load in blood is just as high. And any given patient has numerous strains within. Furthermore, most viral particles are not active: the virus saturates the immune system with de…
So what you're saying is anyone who has HIV has been infected by every single HIV strain?
Re: Antibody Kills 91% of HIV Strains
#44Earlier quoted context omitted.
91% of HIV strains means we are 91% of the way to complete eradication. That is inaccurate. Current antiviral agents remove most (as in over 90%) of the HIV viral particles from the blood of a patient. But then after weeks or months the viral load in blood is just as high. And any given patient has numerous strains within. Furthermore, most viral particles are not active: the virus saturates the immune system with de…
So what you're saying is anyone who has HIV has been infected by every single HIV strain?
Re: Antibody Kills 91% of HIV Strains
#45Earlier quoted context omitted.
> On the other hand, the antibody would never have been noticed if we hadn't been spending all this money on research. Indeed. But, even though he is a homosexual man, the gene would likely be passed along eventually, and run its course through the human race (if we believe Darwin). We just don't want to wait that long. note: it would be passed one of a few ways: 1) his ancestors also had the gene, and he's not the o…
I don't think the gene arose in 40 years. Obviously it didn't, since the man is more than 40 years old. Instead, I think it's a gene that arose via happenstance and is suddenly much more useful.
Still, the fact that it was already floating around I feel proves my point even more. If the disease ravaged us for hundreds of centuries before this cropped up, THEN it'd be pretty reasonable to say it's highly unlikely to develop again anytime soon.
Re: Antibody Kills 91% of HIV Strains
#46Earlier quoted context omitted.
But how many AIDS patients have multiple strains?
All of them
Most HIV people get infected by one strain, but it mutates so rapidly that in a single individual, multiple strains co exist at different levels (a major one and many, many lower levels ones).
Re: Antibody Kills 91% of HIV Strains
#47Earlier quoted context omitted.
For 'Not An Immunologist' you seem to have a pretty good handle on this stuff. You're mostly right about the heritability stuff, but it's a bit more subtle than that. Antibodies are built from heavy and light chains, which are in turn produced by a combinatorial recombination process: subunits get spliced together. While paternal B cells aren't going anywhere with regards to heritability, the heavy/light chain subuni…
Are any antibodies entirely genetically determined--"off the rack", so to speak? One would think that having an innate immune response to extraordinarily dangerous yet infrequently-mutating pathogens (polio, for example) would be worthwhile. Haha, maybe I should get go get an immunology text. I think I'm pushing the limits of Wikipedia.
There is also evidence that this antibody repertoire is further primed and refined by constant interaction with the incredible molecular diversity produced from the bacteria that live on our mucosa (that is, barrier interfaces with the environment like the lining of the gut and lungs and the skin).
The immune system naturally tweaks antibodies to make them more efficient at binding (Affinity maturation it's called). If you are trying to make a vaccine, you are better off starting off with an antibody which has already had all the hard work done on it.
It should be pointed out that the donor they used is actually infected with HIV, the antibody didn't protect him because prior to infection it wasn't affinity matured or present in high enough concentration.
If there was a heirarchy of medical treatments, vaccines would surely be at the top. A jab when you are too young to remember and suddenly debilitating fatal diseases that have plagued humans for thousands of years are no longer a problem. The immune system is unique in that you can give information to it, you can communicate with it. It's an information technology, actually. I think this is why vaccines are so fantastic, it is a treatment that collaborates with the body. Pretty much all other medical therapies involved taking a broken system and breaking it even more to achieve some kind of withered stability which is inevitability temporary and has consequences for the organism as a whole (eg giving steroids for rheumatoid arthritis, chemotherapy for cancer).
The seasonal flu vaccine is a global immune system in action. It's a molecular rss feed, an app update, a glycoprotein tweet whatever analogy you care to use, perhaps one day an individual's immune system will be part of a greater whole linked via information tech. The immune cloud it might be called.
And millions will still die because of war and poor sanitation and exploitation.
Re: Antibody Kills 91% of HIV Strains
#48Earlier quoted context omitted.
Are any antibodies entirely genetically determined--"off the rack", so to speak? One would think that having an innate immune response to extraordinarily dangerous yet infrequently-mutating pathogens (polio, for example) would be worthwhile. Haha, maybe I should get go get an immunology text. I think I'm pushing the limits of Wikipedia.
The process is amazing. It's a giant highly optimized molecular recognition library. Random diversity in antibody binding motifs is generated by guided mutation of the DNA coding for the proteins in the antibody. This wide repertoire is then screened for antibodies that react to 'self' molecular patterns in the body, and the B cells producing those self-reacting antibodies are deleted. One B cell produces only one ki…
Re: Antibody Kills 91% of HIV Strains
#49I remember reading in "The Tipping Point" by Malcolm Gladwell how STDs like HIV can be effectively stopped before they become epidemics. If this antibody can be administered and eliminate a large chunk of people with weaker strains of HIV, then assuming the stronger strains of HIV are in the same geographic area, a strong campaign of eliminating HIV spreading behavior in those areas could really reduce the spread of…
"a strong campaign of eliminating HIV spreading behavior in those areas could really reduce the spread of the disease." That's a LOT easier said than done. There's a widely held belief in parts of the world (such as Africa) that having sex with a virgin cleanses one of AIDS. Because of this, child-rape is extremely prevalent in that part of the world. I suppose you could make the case that education is the easier par…
Re: Antibody Kills 91% of HIV Strains
#50What happens if we manage to kill 91% of the HIV strains? Won't the remaining 9% of the strains continue to spread and mutate? Then we're back to square one.
At the very least, it could buy a second chance for a lot of people, even if it's not all of them. I'm sure there's plenty of people out there who are not career druggies or sluts who had one stupid or unlucky night that is going to ruin the rest of their lives, and could use a second chance. EDIT: sorry, I worded this terribly. What I meant was there are many people who would not catch HIV again, and thus would bene…