Live data from Hacker News

CRISPR eliminates HIV-1 infection in live animals

sciencedirect.com

41–50 of 267 posts

Re: CRISPR eliminates HIV-1 infection in live animals

#41

Last time I read about CRISPR used to remove HIV from infected cells, the virus mutated to defeat the CRISPR attack - could this happen here?

It seems this would be the question when using CRISPR against any virus. Right now one would have to use gene drive to 'amplify' CRISPR and apply it in a living, adult organism (as I understand it). Perhaps some "similar" feedback machanism could be used against quickly mutating viral pathogens?

Re: CRISPR eliminates HIV-1 infection in live animals

#42

As exciting as this is, we already know how people have used the decreased danger of HIV infection to become careless about other types of STIs. Given that our antibiotics are losing their ability to treat many common STIs, an HIV cure without some advancement in antibiotics will be swapping one epidemic for a series of others. Edit: I wanted to add a couple sources for my claims above. Once people stopped believing…

Does that mean we should pull HIV drugs from the market and return to the situation where it's a death sentence?

Re: CRISPR eliminates HIV-1 infection in live animals

#43

As exciting as this is, we already know how people have used the decreased danger of HIV infection to become careless about other types of STIs. Given that our antibiotics are losing their ability to treat many common STIs, an HIV cure without some advancement in antibiotics will be swapping one epidemic for a series of others. Edit: I wanted to add a couple sources for my claims above. Once people stopped believing…

A syphilis epidemic is a lot less deadly and curable than an HIV epidemic. I fail to see your point.

Re: CRISPR eliminates HIV-1 infection in live animals

#44

As exciting as this is, we already know how people have used the decreased danger of HIV infection to become careless about other types of STIs. Given that our antibiotics are losing their ability to treat many common STIs, an HIV cure without some advancement in antibiotics will be swapping one epidemic for a series of others. Edit: I wanted to add a couple sources for my claims above. Once people stopped believing…

> careless about other types of STIs.

Maybe true, though sounds awfully spun. I think a better read is that the early years of the AIDS outbreak were ones notable for particular caution in sexual behavior, not the baseline you want to look at.

> Given that our antibiotics are losing their ability to treat many common STIs

Kinda true, though you seem to be evoking the spectre of a multi-drug-resistant syphilis that AFAIK doesn't exist. It also sorta misses the point that the overwhelming majority of STDs are viral.

> an HIV cure without some advancement in antibiotics will be swapping one epidemic for a series of others

Wat? This doesn't follow. At all. Are you one of those people who opposes the HPV vaccine too because it will lead to more sex?

Re: CRISPR eliminates HIV-1 infection in live animals

#45

It's awesome that this is possible. Right now HIV infections are basically a minor nuisance, provided you're taking the appropriate medication, but this bodes well for future treatment of viral infections.

>Right now HIV infections are basically a minor nuisance, provided you're taking the appropriate medication

The cost of treating an HIV+ person in the US is roughly $400K over the course of their expected lifetime. This is more than a nuisance sum. HIV treatment can also significantly affect quality of life.It is not yet time to become blase.

Re: CRISPR eliminates HIV-1 infection in live animals

#46

It is worth noting that the real challenge in gene therapy at this time is not editing the genes, but in getting sufficient coverage of edited cells (and especially progenitors and stem cells) in an adult individual to achieve the therapeutic goal and make it last. (Most studies of genetic alterations in the broader sense have bypassed this challenge by working with animal lineages, or animals in which the editing ha…

This might be the biggest issue with CRISPR right now. The other issue is that we are not close to knowing what effect manipulating a single gene has on other areas. Especially if this gene is a switch for multiple genes.

Re: CRISPR eliminates HIV-1 infection in live animals

#47
post #32

Back in 2011, there was an announcement from MIT about a new approach to a broad-spectrum antiviral that appeared to work.[1] This goes way beyond an AIDS-specific cure. But it was at MIT Lincoln Labs, which doesn't usually do bio. So the researcher moved to Draper Labs, but didn't get much funding. Then that funding ran out. Now the guy behind this is trying to get funding on Indiegogo.[3] The problem seems to be th…

The funding the scientist is seeking is a pittance compared to MIT's endowment, especially considering they own his patents , they should be funding it.

MIT Lincoln Labs is owned by MIT but operated relatively independently. It is funded, AFAIK from defense spending. Although I'm slightly surprised it wasn't moved to MIT the University.

Re: CRISPR eliminates HIV-1 infection in live animals

#48
post #32

Back in 2011, there was an announcement from MIT about a new approach to a broad-spectrum antiviral that appeared to work.[1] This goes way beyond an AIDS-specific cure. But it was at MIT Lincoln Labs, which doesn't usually do bio. So the researcher moved to Draper Labs, but didn't get much funding. Then that funding ran out. Now the guy behind this is trying to get funding on Indiegogo.[3] The problem seems to be th…

This antiviral is extremely promising, and it boggles the mind how this has not gotten real funding. My cynical side thinks it would cut very deep into a lot of profits for all the various viral medications for lifetime diseases such as the HIV cocktail, herpes meds, and other viral illnesses, so there isn't much upside for a large company to fund this.

Re: CRISPR eliminates HIV-1 infection in live animals

#50
post #32

Back in 2011, there was an announcement from MIT about a new approach to a broad-spectrum antiviral that appeared to work.[1] This goes way beyond an AIDS-specific cure. But it was at MIT Lincoln Labs, which doesn't usually do bio. So the researcher moved to Draper Labs, but didn't get much funding. Then that funding ran out. Now the guy behind this is trying to get funding on Indiegogo.[3] The problem seems to be th…

This antiviral is extremely promising, and it boggles the mind how this has not gotten real funding. My cynical side thinks it would cut very deep into a lot of profits for all the various viral medications for lifetime diseases such as the HIV cocktail, herpes meds, and other viral illnesses, so there isn't much upside for a large company to fund this.

That theory would work except that if that were the case they would've bought him out and shut it down. Everyone wants to make money, as it stands someone will and they can be from any sort of background. Why hasn't a silicon valley head given this guy a few million though is beyond me.
Post reply on HN