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Teenager's sickle cell reversed using a treatment to change his DNA

bbc.com

41–50 of 78 posts

Re: Teenager's sickle cell reversed using a treatment to change his DNA

#41

Earlier quoted context omitted.

Not impossible but much, much, much more plausible with embryos. Modifying billions of neurons is a very, very tall order, and would likely be much less effective after the brain is grown. Embryo selection and modification are almost doable now, we just don't know which alleles to select for or edit in. A gift you can give your children but one you are unlikely to be able to get for yourself.

This is true, as much as I disagree with his ideas. Trying to genetically modify a living adult across many cells is very difficult.

Who's ideas?

Re: Teenager's sickle cell reversed using a treatment to change his DNA

#42
"He no longer requires a transfusion so we are quite pleased with that"

I like that language so much more than, than the increasing THIS IS AMAZING, SO AWESOME, WHAT WE GREAT GUYS ACCOMPLISHED!!! even though it would fit here much more, than in the usual context people use it fore ...

Re: Teenager's sickle cell reversed using a treatment to change his DNA

#43
post #30

Is this using CRISPR or some other method of editing the DNA?

This treatment does not use CRISPR. It involves the hollowed out and repurposed lentivirus (similar in kind to HIV)[1]. The virus keeps it's own viral 'insert-into-DNA' machinery, but is stripped of its replication machinery as well as the code for its physical shell. The insert-into-DNA machinery is further hijacked so it can insert nothing but the DNA that encodes for the new mutated hemoglobin (HBB [T87Q][2]) that…

Applying the patch directly on production, with no backups, too (!)

Re: Teenager's sickle cell reversed using a treatment to change his DNA

#44

"He no longer requires a transfusion so we are quite pleased with that" I like that language so much more than, than the increasing THIS IS AMAZING, SO AWESOME, WHAT WE GREAT GUYS ACCOMPLISHED!!! even though it would fit here much more, than in the usual context people use it fore ...

I don't think I have ever seen medical professionals speak in the manner you described.

Re: Teenager's sickle cell reversed using a treatment to change his DNA

#45

"He no longer requires a transfusion so we are quite pleased with that" I like that language so much more than, than the increasing THIS IS AMAZING, SO AWESOME, WHAT WE GREAT GUYS ACCOMPLISHED!!! even though it would fit here much more, than in the usual context people use it fore ...

I don't think I have ever seen medical professionals speak in the manner you described.

I did not say that, I was talking about other tech branches, startup hype speak etc.

Re: Teenager's sickle cell reversed using a treatment to change his DNA

#46

Earlier quoted context omitted.

I don't think I have ever seen medical professionals speak in the manner you described.

I did not say that, I was talking about other tech branches, startup hype speak etc.

Aha my mistake.

Re: Teenager's sickle cell reversed using a treatment to change his DNA

#47

Earlier quoted context omitted.

Nope. Genetic engineering works far, far better. We've already plucked the low hanging fruit of adequate nutrition, early education, salt iodization, and lead reduction. Anyway, those reduce mental retardation, they don't improve the baseline too much. And the Flynn effect looks to be slowing or reversing. 50 IQ points is huge. It's the difference between a burger flipper and a physics professor. The change to the wo…

People in Flint, Michigan still don't have clean water. Lots of other folks in the world also don't have clean water. Doesn't that seem like an easier thing to fix than trying out experimental therapies?

This might particularly interest you: http://www.lettersofnote.com/2012/08/why-explore-space.html

The gist of it is, in 1970 someone asked a director of NASA why billions of dollars were being spent on exploring space when millions of children were still dying on Earth. The response in part explained that NASA's R&D was paving the way for satellites with better weather forecasting, better communications, and better equipment that was making its way into people's everyday lives. While a bit morbid to say, the advancements made by NASA have arguably saved many more lives in the long run.

It's hard to see the point in investing in experimental technology whose payoff is unknown, especially when we have definite problems with feasible solutions. That doesn't mean we shouldn't try. The possible payoffs - cancer cures, age prolongation, enhanced food production, disease and sickness prevention - that can come from investing in gene therapies are just too great to ignore.

As a side-thought, the technological singularity is thought of as the point at which we create an AI smarter than us, triggering a run-away effect of self-improvement. What if we end up doing it to our own race first through intelligence-improving gene modification? Can you imagine the implications of applying that intelligence to solving the rest of our problems?

Re: Teenager's sickle cell reversed using a treatment to change his DNA

#48

Earlier quoted context omitted.

A better way to increase iq would be to raise the socioeconomic level...

Nope. Genetic engineering works far, far better. We've already plucked the low hanging fruit of adequate nutrition, early education, salt iodization, and lead reduction. Anyway, those reduce mental retardation, they don't improve the baseline too much. And the Flynn effect looks to be slowing or reversing. 50 IQ points is huge. It's the difference between a burger flipper and a physics professor. The change to the wo…

You sound like you went to Trump University? Sorry, but even here, I can only take so much.

Re: Teenager's sickle cell reversed using a treatment to change his DNA

#49
post #30

Is this using CRISPR or some other method of editing the DNA?

This treatment does not use CRISPR. It involves the hollowed out and repurposed lentivirus (similar in kind to HIV)[1]. The virus keeps it's own viral 'insert-into-DNA' machinery, but is stripped of its replication machinery as well as the code for its physical shell. The insert-into-DNA machinery is further hijacked so it can insert nothing but the DNA that encodes for the new mutated hemoglobin (HBB [T87Q][2]) that…

CRISPR is typically delivered via a lentivirus.

Re: Teenager's sickle cell reversed using a treatment to change his DNA

#50

Earlier quoted context omitted.

I agree with this, but not a popular opinion. Hence the down votes you are getting. Korea and China don't have the same memetic immune response to such ideas, injecting one's children with growth hormone in hope of increasing future job prospects, for example, is extremely common in Korea. I suspect embryo selection and generic engineering for increased IQ will take off in East Asia first. Then we will be forced to a…

A better way to increase iq would be to raise the socioeconomic level...

No amount of life quality can raise iq by the magnitude in the parent post.
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