There's this http://www.unigui.com make all your web apps in Delphi :-), they've been in beta for a long time but seems to work.
Good find. Some opinions: http://stackoverflow.com/questions/3649969/what-do-you-think...
No source for bits of it which makes it risky since it seems there's only one guy developing it.
Looking at it's comms it seems pretty lightweight, though it does generate a lot of messages.
Last time I looked the Sencha library it used was fairly old
That said if you've got a low-medium weight web app you want to build and don't care if it looks like windows, then it's dead easy (really 1 day or so, it's that easy).