I remember watching an interview with the creators of South Park in which they described the transition from animating using cardboard cutouts to a system with CorelDraw and other pieces of software which helped speed up the process. The bulk of the efficiency improvement came from carefully defining all the frequently used objects (characters, houses) once with movable components, and reusing those objects in the pe…
This would be a great proof of concept, in fact someone should work on this as a pet project, but I doubt it would be worth as an investment in the rest of the show's run. I bet they don't spend a lot of time on the basic animation anymore, and instead focus mostly now on one-off set pieces and visual effects