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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

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Re: Semaglutide linked to lower predicted dementia risk

#391

Post by alyandon »

anon291 wrote: post #165
alyandon wrote: post #69

Earlier quoted context omitted.

Similar experience here on minimal dose of GLP-1. There is definitely something going on here other than "you are just losing weight and that's really why you are healthier". With my labs at my current weight you can not tell that I am a type 2 diabetic. Previously, when I was at this very same weight in the past - all my labs indicated I was prediabetic.

A lot of metabolic stuff is due to insulin and insulin sensitivity. This drives pretty much everything. Insulin sensitization is pretty terrible and it gets more important as you age. Unfortunately natural selection doesn't need to fix this as it doesn't cause issues until after reproduction and often until after your grandkids are born. Semaglutide and glp1s resensitize it which is why they have these effects. My op…

I strongly suspect that it has had an impact on my insulin sensitivity as well.

Re: Semaglutide linked to lower predicted dementia risk

#392

Post by BobbyJo »

alyandon wrote: post #69
jaggederest wrote: post #64

Earlier quoted context omitted.

I have some individual anecdotal evidence. I spent a long time, basically a year, relatively heavy but on a very small dose of GLP drugs due to tolerability issues, and my labs improved dramatically , to a degree we redid them out of disbelief, even without weight loss. I believe one of the suspected underlying causes is reduction in fatty liver despite constant body weight and composition, and also inflammation redu…

Similar experience here on minimal dose of GLP-1. There is definitely something going on here other than "you are just losing weight and that's really why you are healthier". With my labs at my current weight you can not tell that I am a type 2 diabetic. Previously, when I was at this very same weight in the past - all my labs indicated I was prediabetic.

Being weight X while gaining weight is a significantly different metabolic state than being weight X while losing weight.

Re: Semaglutide linked to lower predicted dementia risk

#393

Post by blensor »

preg_match wrote: post #223
aucisson_masque wrote: post #192

Earlier quoted context omitted.

Could be just because you stopped eating bad food. Things improve dramatically once you limit your intake of industrialized food.

Not that dramatically. Things like fatty liver take a long time to reverse. It’s not like you stop eating junk food and then suddenly your body is chilling. No, the damage is done and takes a long time to repair. It’s like smoking. You can benefits from quitting smoking within 20 minutes. But to reach the full benefit and reversal, you need 15 years.

About 2 years ago I my cardiologist wanted to put me on medication because my blood test was already so bad ( prediabetic, liver was impacted, overweight, etc. )

However I wanted to try to get it under control myself ( cutting out almost all carbs, liver friendly diet, lot's of exercise ), she didn't think it would make a difference but she humored me and gave me a 3 month period to try and get it back to normal.

This year ( about 2 years since I started and about 1 3/4 years since my values were good ) she told me that she now has to completely remove prediabetis from my diagnosis because she can no longer justify it based on all the tests we did since then.

Re: Semaglutide linked to lower predicted dementia risk

#394

Post by sizzle »

stephbook wrote: post #344
sizzle wrote: post #297

Earlier quoted context omitted.

How has it been treating you? Do you keep muscle mass without having to hit 1g/lb of protein intake daily?

Haven't measured it exactly, but haven't noticed a reduction in my lifts either. I do have a home gym, throttled my marathon training and try my best with Skyr and protein shakes though.

Any idea if a pill form will be available in the future?

Re: Semaglutide linked to lower predicted dementia risk

#396

Post by bgnn »

nwienert wrote: post #305
Aurornis wrote: post #35

Earlier quoted context omitted.

> and very likely the weight-loss and a lot of the other emerging benefits are likely the effects of reduced inflammation. That’s not correct. GLP-1s interact with satiety (fullness) circuits and reduce appetite. They also have minor effects delaying gastric emptying, meaning the stomach stays full longer. There is some early data suggesting that they might reduce some inflammation markers slightly more than weigh lo…

> The question now is if GLP-1s have additional anti-inflammatory influence. This is well established, not at all a question. > they might reduce some inflammation markers slightly more than weigh loss alone There's no "slightly," It's going to be a news story for years to come. It's a broad spectrum anti-inflammatory drug of a breadth and efficacy never seen before.

Can you please share a good reference on this? All I read about GLP-1 stuff is popular science style punlications. I'm genuinely interested in learning about their benefits over reducing caloric intake, i.e. diet.

Re: Semaglutide linked to lower predicted dementia risk

#397

Post by highfrequency »

alyandon wrote: post #69
jaggederest wrote: post #64

Earlier quoted context omitted.

I have some individual anecdotal evidence. I spent a long time, basically a year, relatively heavy but on a very small dose of GLP drugs due to tolerability issues, and my labs improved dramatically , to a degree we redid them out of disbelief, even without weight loss. I believe one of the suspected underlying causes is reduction in fatty liver despite constant body weight and composition, and also inflammation redu…

Similar experience here on minimal dose of GLP-1. There is definitely something going on here other than "you are just losing weight and that's really why you are healthier". With my labs at my current weight you can not tell that I am a type 2 diabetic. Previously, when I was at this very same weight in the past - all my labs indicated I was prediabetic.

Very cool - to be clear, are both your diet composition and calorie intake similar before vs. after?

Re: Semaglutide linked to lower predicted dementia risk

#398

Post by avgDev »

Lagoon3384_SWE wrote: post #334
throwaway82931 wrote: post #110

Earlier quoted context omitted.

All my immediate family members are obese. I'm not (BMI 24.5, borderline overweight at the high end of normal, highest lifetime BMI was 29.5), but that's through strenuous, exhausting effort over decades. I also exercise regularly, though I've learned over time how disconnected exercise is from weight management. At my weight, I'm not a candidate for going on a GLP-1. I'm sure I could find an unethical doctor to pres…

Very american thread and comments. At most I was 24 BMI and I felt like a fat bastard during COVID. Work from home in sweatpants and I got up to 24 BMI. 77-78kg, 182cm. I just did not weigh myself so I actually did not notice I had gained! But I did and decided to do something about it. But I lost the weight pretty quickly. I grew up at 60-65kg and that is where I feel at home in my body. I feel like myself basically…

Commenting here to add I am at 22 BMI and also feel fat. I am also a degenerate gamer. I realized gaming is actually feeding my ADHD and makes my brain feel "nice". My whole life is just dopamine seeking. My sleep has been trash for years.

Bad sleep also worsens my diet and makes me more hungry.

For me to have a healthy lifestyle I need to treat my ADHD first and quit multiplayer games.

Re: Semaglutide linked to lower predicted dementia risk

#399

Post by 4d4m »

to11mtm wrote: post #97
hattmall wrote: post #42

Earlier quoted context omitted.

Treat junk food like cigarettes

And have a real conversation around Corn syrup. Even today, a Soda with 'real sugar', at least for me, is far more satiating for thirst or a 'quick sweet treat' than the same brand/'flavor' using corn syrup, that includes both the big chains as well as the local names. If I drink a soda with sugar in it, I usually wind up wanting water after. If I drink something with corn syrup, I usually just want more of whatever…

The production of corn syrup is disgusting and its weird we don't talk more about how it is made. Enzymes are for cheese and fermented foods not for subsidizing the manufactured food industry!

Re: Semaglutide linked to lower predicted dementia risk

#400

Post by 4d4m »

brokensegue wrote: post #168
tacon wrote: post #147

Earlier quoted context omitted.

No, the evidence is that there is no significant difference in satiety. HFCS is 55% fructose / 45% glucose, while sucrose is 50% fructose / 50% glucose.

yeah that was my understanding. for some reason corn syrup is vilified. the real problem there (as I understand it) is corn subsidies.

Ding ding ding. HFCS is a tax we all pay for no reason anyone in the general populace actually wants.
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