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Semaglutide linked to lower predicted dementia risk

alz-journals.onlinelibrary.wiley.com

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Re: Semaglutide linked to lower predicted dementia risk

#381

Post by onefish »

dripdry45 wrote: post #373
onefish wrote: post #303

Earlier quoted context omitted.

I have a very similar situation: on it for about a year, 220lbs to 180 at age ~40. Also very active: weight lifting / biking / swimming and - the sport that made me realize I needed to loose weight - rock climbing. I've always been very outdoorsy-adventurous, and climbing/mountaineering is the natural sort of "end game" for this lifestyle. My weight never really got in the way of anything else in my life (maybe my se…

Thanks for the details, really liked your posting this. As a former Climber, moved to an area that doesn’t have a decent rock Gym and bought a house, this is inspiring. I have a chance to climb again and it will require losing some weight loss. I’m just a hair into the overweight category at the doctor. One question: how tall are you?

I'm about 5'10", so technically "just a hair into the overweight category" as well, hence the desire to loose another 10lbs. Sounds like you'd be starting where I took a year getting to, so go get after it.

Re: Semaglutide linked to lower predicted dementia risk

#382

Post by vladvasiliu »

dawnerd wrote: post #242
SubmarineClub wrote: post #170

Earlier quoted context omitted.

> metabolic changes that make weight loss harder Which are vastly overblown. I diet every year as part of bodybuilding, at a range of intensities and durations, and have never had issues with sudden metabolic changes that make it harder to lose weight.

See that’s the problem. What works for you doesn’t work for others like me that have tried dieting. It’s the food noise that’s the problem and it’s a mental issue. Glp-1 has helped me a lot. The metabolic changes are kind of insane. Even doing keto which did help lose weight didn’t have this kind of effect on me.

> It’s the food noise that’s the problem and it’s a mental issue.

Yes, I've been through this, and I think it's the reason I got fat in the first place. I had a constant feeling of hunger, but which was "fake", as some other commenter put it, since I was clearly eating more than enough.

But I've found that one way to fight this, which at least worked for me, was not just eating less, but eating differently. I increased foods with low calories per volume, such as salads, peppers, peas, and the like, and combined them with some form of high-protein, low-fat meat. This fills my stomach for a good while, and this feeling of fullness chased away the food noise. I just couldn't think about eating anything, since my belly still seemed full a long time after the meal.

Re: Semaglutide linked to lower predicted dementia risk

#383

Post by throwaway82931 »

phil21 wrote: post #279
throwaway82931 wrote: post #110

Earlier quoted context omitted.

All my immediate family members are obese. I'm not (BMI 24.5, borderline overweight at the high end of normal, highest lifetime BMI was 29.5), but that's through strenuous, exhausting effort over decades. I also exercise regularly, though I've learned over time how disconnected exercise is from weight management. At my weight, I'm not a candidate for going on a GLP-1. I'm sure I could find an unethical doctor to pres…

> I'm sure I could find an unethical doctor to prescribe it if I looked hard enough I'd say the only unethical doctors here would be the ones not prescribing it for you based on your description of your life and needs. Guidelines are guidelines, not strict rules for a reason. BMI is not the end-all measurement to decide if you are a candidate for these drugs. Find a competent doctor who understands GLP-1s and you mig…

I have a Kaiser Permanente health plan via the ACA. I assume based on capitalist incentives that Kaiser would fire my primary care physician for prescribing outside the official guidelines.

But I've been thinking about this for a while and I'll talk to him anyway about the prospect of going on a low-dose GLP-1. If he's unreceptive then I'll ask about how to find a trustworthy out-of-network physician who isn't bound by the same incentives.

Re: Semaglutide linked to lower predicted dementia risk

#384

Post by jaggederest »

preg_match wrote: post #371
inglor_cz wrote: post #361

Earlier quoted context omitted.

People in certain regions always ate a lot of meat. For example, the Inuit don't really have anything else to eat. Nothing edible grows that far North. And they are neither obese nor suffer from classical diseases of civilization, until they start eating highly processed modern food. The Maasai are also known to eat a lot of meat and dairy.

I'm sure you can eat a diet fairly high in meat and dairy and be healthy, IF you are lean enough and exercise enough. However, I can pretty confidently say the Intuit did not eat nearly as much meat and dairy as modern Americans. And, the meat they did eat was not the same because it was wild, not farmed. But, humans have been eating unsaturated fat from nuts, seeds, and meat for millennia. Unsaturated fat is not the…

> However, I can pretty confidently say the Intuit did not eat nearly as much meat and dairy as modern Americans.

Incorrect, your points are otherwise true. Inuit diet was close to 100% animal products, way more than anyone but carnivore diet people today eat.

Re: Semaglutide linked to lower predicted dementia risk

#385

Post by tsoukase »

anovikov wrote: post #346
tsoukase wrote: post #345

Diabates can harm the brain either indirectly, through vascular damage, or directly through nerve cell degeneration. The latter is a less studied mechanism and can explain the benefit from GLPs. But I agree, it's not different than a low calorie diet. In the modern times of abundance and sedentary lifestyle, fasting makes wonders. So, if you have even one vascular risk factor, just cut your calories in half, just sto…

GLP-1 provides the only plausible way to do so.

Let's not be absolute. There are some people craving for food (esp. endomorphs), some binge eaters (eg under depression) or low metabolizers (hypothyroid) but for many it's easy to cut calories.

Re: Semaglutide linked to lower predicted dementia risk

#386

Post by inglor_cz »

preg_match wrote: post #371
inglor_cz wrote: post #361

Earlier quoted context omitted.

People in certain regions always ate a lot of meat. For example, the Inuit don't really have anything else to eat. Nothing edible grows that far North. And they are neither obese nor suffer from classical diseases of civilization, until they start eating highly processed modern food. The Maasai are also known to eat a lot of meat and dairy.

I'm sure you can eat a diet fairly high in meat and dairy and be healthy, IF you are lean enough and exercise enough. However, I can pretty confidently say the Intuit did not eat nearly as much meat and dairy as modern Americans. And, the meat they did eat was not the same because it was wild, not farmed. But, humans have been eating unsaturated fat from nuts, seeds, and meat for millennia. Unsaturated fat is not the…

The Inuit don't really have any choice, nothing of nutritional value grows up there. They also prefer fat to lean meat, no surprise in conditions of the Far North. Also, during the Polar Night, they didn't move that much.

I agree that the fact that this meat and fat is wild may be the root cause of the differences between their and our health outcomes. That indicates, though, that we may have something in our forms of meat and dairy that potentially harms us - and that if we identify what, we may be able to get rid of that specific problem.

Re: Semaglutide linked to lower predicted dementia risk

#387

Post by inglor_cz »

adjejmxbdjdn wrote: post #359
somenameforme wrote: post #295

Earlier quoted context omitted.

No idea where you're getting this from. The paleolithic was during an ice age full of big fatty game like sloths, mammoths, and so on. Some believe we hunted these animals to the point of extinction with a tiny population, which would imply a very high level, arguably unbelievably high, of consumption of meat. Even if we didn't hunt them to extinction we certainly did engage in relatively large scale hunting and cons…

This is just not true. In reality we have little to no idea what the proportion of meat to non meat humans ate at the time. More realistically, different groups of humans ate different ratios of such foods. There were almost certainly a pretty large group of humans, for example, who were basically frugivores. You can simply look up Wikipedia and find all the references about our limited knowledge and the high likelih…

IIRC you can analyze dental calculus found on teeth and detect the proportions of various protein sources in the diet of that individual, but IDK how far back in time you can do this.

Several hundred years is certainly possible, Medieval cemeteries can be analyzed like that.

(Whenever my dentist cleans my calculus, we joke that we are ruining some future archeologist's work :)

Re: Semaglutide linked to lower predicted dementia risk

#388

Post by sowbug »

01100011 wrote: post #205
loeg wrote: post #133

Earlier quoted context omitted.

Maybe start lifting weights again? 50 isn't a death sentence; I know a lot of competitive 50s-year-olds.

I'm trying but I've got a toddler and now it seems like every joint hurts. No time to get to a gym and no room for a decent home gym. I did start to do back day again at the Y when we go on the weekend for the pool. We'll see...

One small thing to try is so-called Asian squats while you're playing with your kid.

Hip and groin neuralgia started suspiciously soon after my tirzepatide weight loss. I seem to have gotten it under control after mobility exercises centered around squatting. It took almost six months to get from falling backwards to being able to squat flat-footed. Now it's a comfortable and useful stance.

My theory is the weight loss shifted my center of gravity, calling on muscles and joints that weren't ready for the load. Learning to squat helped the new version of my body relearn how to support itself.

Re: Semaglutide linked to lower predicted dementia risk

#389

Post by anukin »

declan_roberts wrote: post #39
01100011 wrote: post #27

Earlier quoted context omitted.

Semaglutide cleared my liver fat and fixed my moderate NAFLD in a matter of months. Why is retatrutide necessary?

Retatrutide has a specific mechanism for clearing liver fat (glucagon) which makes it one of the most effective ways to treat T2D. This is the 3rd agonist not found in semaglutide or tirzepatide.

Might be a noob question. What does the liver and clearing of fat have to do with inability of body to clear the sugar from blood?

Re: Semaglutide linked to lower predicted dementia risk

#390

Post by alyandon »

aucisson_masque wrote: post #192
alyandon wrote: post #69

Earlier quoted context omitted.

Similar experience here on minimal dose of GLP-1. There is definitely something going on here other than "you are just losing weight and that's really why you are healthier". With my labs at my current weight you can not tell that I am a type 2 diabetic. Previously, when I was at this very same weight in the past - all my labs indicated I was prediabetic.

Could be just because you stopped eating bad food. Things improve dramatically once you limit your intake of industrialized food.

My diet consisted mostly of lean meats like chicken and vegetables.
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