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My 16-month theanine self-experiment

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Re: My 16-month theanine self-experiment

#381

Anecdotally, I’ve found that theanine radically increases the vividness and memorability of my dreams. Of course that might be be a great effect depending on the content of my dreams. That could mean deeper sleep, but I’ve not really measured that.

It does that for me too, but usually that seems to result in worse sleep.

Re: My 16-month theanine self-experiment

#382
post #367
post #356

Earlier quoted context omitted.

I would have taken a well-calibrated photo of the cup each time without looking, maybe with a color card in the bottom, and only entered results at the end of the trial. Given that there is no documentation of whether the events during the hour of test time were more or less stressful than those before it, and no taking the time of day, diet and exercise, sleep, location (quiet island or next to a construction site),…

> As a note, I have no idea why he bothered trying to guess what he had taken. What possible value could that have in this type of experiment? It gives a hint of how well the blinding worked.

Yes, that is a good point. But it also causes him to continuously think about indicators to determine what he has taken. He is constantly trying to punch the veil on this "blind" study instead of doing everything he can to avoid that. Are they really the exact same weight? Do they really feel the same in his hand, mouth and throat? Does one have a slightly different taste - after all, no filling process will leave the outside of the capsule 100% free of powder, etc? Very subtle differences could manifest themselves over 16 months.

Re: My 16-month theanine self-experiment

#383
post #238
post #225

Earlier quoted context omitted.

Citizens science used to be much more common and there were several publications initially built around the concept. Unfortunately, the idea has all but been obliterated by inadequate public education and the chronic lack of time that now embattles the middle classes.

fortunately* citzen science was replaced by solid methods... this is a long fancy self reported post on a metric that is easily figured out by biomarkers (stress levels). what's the consequences if the author decided to make some claim about a substance?

I think you are ignoring the fact that citizen science was alive and very well up into the 1980s. It was never a replacement for professional science, but rather citizen scientists often observed things that were deemed worth of follow-up by academic researchers.

Citizens scientists rarely post “facts” but rather interesting avenues for research or further investigation. Part of being an educated citizen scientist is to understand the limitations of your knowledge, data, and methods.

Quacks and cranks, on the other hand, are always making grand new “discoveries” lol.

Anyone who has a decent education can make observations apply the scientific method. I say this coming from a family of actual scientists from molecular biology to particle physics, who will tell you the same, and also give credit to the multitude of citizen scientists who have done just that.

As for myself, I’ll stick to engineering.

Re: My 16-month theanine self-experiment

#384

Earlier quoted context omitted.

Do you have ADHD? Most neurotypical people seem to experience jittery effects and being extremely alert while for people with ADHD it can actually make them sleepy. Of course everyone's brain is different, it is just a correlation with many exceptions. So yeah, caffeine works differently on different people. Personally, as someone with ADHD, I have a crazy caffeine tolerance. It helps me somewhat with focus but I don…

I have ADHD and caffeine very easily makes me jittery. Ordering my cappuccino 'half-caff' has terrifically improved my life. Stimulant medication, the kind prescribed by the doc, easily makes me jittery, too. The narrative that 'stimulants calm down people with ADHD but make neurotypicals wired' never sat well with me. But I totally believe that it makes you and many other people calmer without any friction. There mu…

> Stimulant medication, the kind prescribed by the doc, easily makes me jittery, too.

How do you treat your ADHD then?

Re: My 16-month theanine self-experiment

#385

Earlier quoted context omitted.

It’s almost as if this post is attempting to gaslight the world into thinking that L-Theanine doesn’t work. It’s the exact equivalent of saying “Look at the data, LSD does not make you hallucinate, it’s just conjecture. Look at my data and numbers.” This entire post makes me think there is either an ulterior motive for writing it to try and discredit the obvious impact L-Theanine has on people, or, the write up is si…

What makes you think it is trying to gaslight anyone? The post makes it clear that it just not working on the author is a possibility, but also fairly points out that there are other studies with more participants that weren't really promising either. It then suggests that those who do really believe it works on them also replicate a blinded self-experiment, which seems pretty fair to me - because then surely they'd…

> The post makes it clear that it just not working on the author is a possibility,

This is my hypothesis. I'm very confident it worked for me, but I'm guessing that there's a certain combination of symptoms and traits that it's effective. If it was a placebo for me, it would be literally a miracle: likely the cheapest thing I've tried and had the biggest effect without requiring me to make a habit out of taking it.

Re: My 16-month theanine self-experiment

#386
post #13

I was surprised that the author’s conclusion didn’t mention another model that looked consistent with the data: that theanine works slowly — over the course of a few days, not hours. (I have no idea whether it would work like this. A placebo effect only is also consistent with the data.)

> that theanine works slowly — over the course of a few days, not hours

This was my experience. I'm not sure if that's "typical", although I've never really tried to take it like that.

Re: My 16-month theanine self-experiment

#387
Amino Acid therapy requires an empty stomach, and the postulated effects usually require larger doses. But that would blow up his experiment design. Also there can be time of day widows for efficacy. Science has gotten far with lock and key receptor models. But some of this stuff can be sensitive to time and cofactors, beyond genetic and epigenetic individual variance.

Re: My 16-month theanine self-experiment

#388

For anyone looking for a sleep supplement, before you go down the rabbit hole of Theanine, Mg, etc. Try an OTC Azelastine or Fluticasone nasal spray for a month. Turns out my chronic poor quality, restless sleep was a dust mite allergy that I should have figured out and treated a decade ago. Would wake up with a stuffy nose and very dry mouth but didn't have too many issues during the day. I was allergic to my bed. B…

You are aware of mattress covers for Dust Mites? And there is an enzyme additive for laundry. Finally a hand steamer for upholstered stuff. I had bad hives from allergies to them, and a medical resident suggested a clearing of all fabric in my life, as best as I could.

Re: My 16-month theanine self-experiment

#389

For anyone looking for a sleep supplement, before you go down the rabbit hole of Theanine, Mg, etc. Try an OTC Azelastine or Fluticasone nasal spray for a month. Turns out my chronic poor quality, restless sleep was a dust mite allergy that I should have figured out and treated a decade ago. Would wake up with a stuffy nose and very dry mouth but didn't have too many issues during the day. I was allergic to my bed. B…

nice! I recently got dust mites out of my home completely, and it was a miraculous upgrade to my health, including several symptoms that are outside the definitions of allergic asthma/eczema/rhinitis. One important thing people are missing about dust mite allergy is the many ways in which they directly damage your immune system and body, outside of the usual frame of "allergies" which is based on type 2 hypersensitiv…

Another simple hack is to exit your outside the home outer clothes when you get home. There are virulent extra allergic dust mites, that has really helped my family. And these products can help with laundry at lower temps and harder to launder items. https://elfbrands.com/collections/elf-brands

Re: My 16-month theanine self-experiment

#390

Earlier quoted context omitted.

And that is exactly the point made in the target post by the author. He explicitly raised that criticism himself. Double kudos for self-criticism. You will not find many conventional science publications pointing out: “Shucks, we could have done this a better”.

The ancestor post is neither a "Complete injustice" nor "derision" nor an "insult", and it doesn't warrant a hostile mocking reply. Its tone could have been gentler, but it wasn't that bad. And the study doesn't really deserve "accolades", it deserves to be recognized for whatever it does well. Such polarization of tone and vocabulary doesn't accomplish much, and I'll even propose that it actually prevents good thing…

Yes, perhaps. But please tell me you have read the original post. It is thoughtful, self-deprecatory, careful, well analyzed, and upfront about limitations and possible improvements.

Re-reading such a negative critique of a solid home-brew experiment is unwarranted. There are several word here worth red flags.

>This is an N=1 trial. Dressing your N=1 trial up with lots of pseudo controls and pseudo blinding and data collection does not make it better. In fact: putting this much effort into any medication trial makes it much more likely that you’re going to be incentivized to find effects that don’t exist. I think it’s nice that the author admits that they found nothing, but statistically, worthless drugs show effects in much better-designed trials than this one: it’s basically a coin toss.

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