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GLP-1 drugs: An economic disruptor? (2024)

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Re: GLP-1 drugs: An economic disruptor? (2024)

#381

Post by bcoates »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

I don't have a published study to back this up, but in my 10 Giving a GLP-1 to a heavy drinker/alcoholic results in a skinny alcoholic.

Given that the overwhelming majority of alcohol is consumed by heavy+ drinkers this isn't the gamechanger people think it is.

Re: GLP-1 drugs: An economic disruptor? (2024)

#382

Post by Earwig »

raphman wrote: post #253

Is this person an expert of any kind? They throw around dozens of numbers without any sources. For example, > 'A movie theater chain recently analyzed their user data and discovered that 72% of their profits came from concessions, primarily from impulse purchases made by people who swore they "wouldn't buy anything."' This combination of non-descript source, precise numbers, and 'quotes' looks like the usual bullshit…

Yeah, I’m also having a lot of trouble finding sources for the specific claims they’re making (even, say, the NFL stadium redesign thing, which feels like it should be easy to find). And taking into account the AI-generated lead image, I’m a bit skeptical of all this.

Re: GLP-1 drugs: An economic disruptor? (2024)

#383

Post by mlboss »

cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

What are the side effects ? I heard these drugs just freezes the intestine.

Re: GLP-1 drugs: An economic disruptor? (2024)

#384

Post by IG_Semmelweiss »

derkster wrote: post #318
willis936 wrote: post #64

Earlier quoted context omitted.

Because anorexia exists it would do harm to completely unregulate access to appetite suppressants. Someone should be looking out for people who would willingly wither away.

Putting Ozempic over the counter at a local pharmacy would be more than enough to keep people from wasting away, the same thing they do with asthma medication. In 2025, if you really want something, a dark web tutorial is 30 seconds away. And from what I've heard from a client, Ozempic on the dark web is roughly 5x cheaper.

sure thing, but can you trust it ? There are so many horror stories abroad (like LATAM), that despite the 4x price point, people still buy US-manufactured GLPs instead of going to a foreign market to get the same prescription.

This is being injected directly into your flesh, there cannot be any mistake, or shortcut.

Re: GLP-1 drugs: An economic disruptor? (2024)

#385

Post by gcanyon »

homebrewer wrote: post #335
gcanyon wrote: post #154

Earlier quoted context omitted.

> Losing too much weight too quickly, with or without the help of a drug, can be very unhealthy. Is there evidence to back this up? It sounds reasonable, especially without a limit on "too quickly" but (anecdata incoming) I'm curious because: - When I first tried a low-carb diet (for non-weight reasons) I lost about thirty pounds in under three months without really trying, and hit something like 12% bodyfat - When I…

Anecdotally (but in line with what I read about this), I got gallstones after getting rid of 30 kgs in about 6 months, which is too fast for losing a third of your body weight. Since I had a scan before starting the diet for unrelated reasons, I'm sure they weren't there before.

Yikes, good luck with that. Fortunately nothing like that here.

Re: GLP-1 drugs: An economic disruptor? (2024)

#386

Post by SoftTalker »

jrochkind1 wrote: post #306
SoftTalker wrote: post #67

Earlier quoted context omitted.

People who don't need to be chronically medicated should not be. There are always side effects, and we don't even know for sure what the long term risks of these medications are yet. And crowing about saving $200/mo not buying food at Starbucks, well now Novo Nordisk is getting that. Toast a bagel at home for $0.50/day instead.

what kind of crap bagels are you buying for 50 cents?

What do you think Starbucks pays for theirs?

I buy Thomas Everything bagels at the supermarket, FWIW.

Re: GLP-1 drugs: An economic disruptor? (2024)

#387

Post by IG_Semmelweiss »

blackeyeblitzar wrote: post #158
cj wrote: post #61

Earlier quoted context omitted.

Luckily during the “shortage” you can currently get GLP-1’s in vials rather than injection pens. The brand name GLP’s you can’t control the dose. But when you get it in a vial from a compounding pharmacy you can inject however much or little you want. Not looking forward to ever using the brand name version specifically for this reason

Aren’t any states like California trying to ban compounding pharmacies? It’s an unfortunate attack on individual freedom, but I am not sure if we will still have them 20 years from now.

what is happening is more complicated.

First, there's no legislation. What is happening is that the branded drug was in shortage so compounding pharmacies were legally allowed to step in under existing regulations.

The shortage status was first updated in the summer, and Novo went on a lawsuit spree. Suing everyone mentioning GLP on a website.

But, there have been more back and forths since, very recent.

TLDR what is restricted now is not the sale of the compound, but the manufacture of it. Therefore, you can keep selling inventory past the restriction, but of course that will either run out, expire, or be restricted as well. As of now, if everything stays the same, expect the last few compound pharmacies to run out of product at the end of Q3/25 .

However, I understand there's groundbreaking legislation being worked on that will dramatically change the status quo for the better, meaning more choice for end consumers and less profits for Novo.

Re: GLP-1 drugs: An economic disruptor? (2024)

#388

Post by gcanyon »

machomaster wrote: post #196
gcanyon wrote: post #154

Earlier quoted context omitted.

> Losing too much weight too quickly, with or without the help of a drug, can be very unhealthy. Is there evidence to back this up? It sounds reasonable, especially without a limit on "too quickly" but (anecdata incoming) I'm curious because: - When I first tried a low-carb diet (for non-weight reasons) I lost about thirty pounds in under three months without really trying, and hit something like 12% bodyfat - When I…

The issues with "too quickly" are: 1. the loss of muscle mass 2. low energy 3. unnecessary suffering 4. high fatigue 4.1. inability to maintain the low calorie diet for long enough 4.2. relapse; jojo-dieting. 1, 4.1 and 4.2 are the biggest problems.

1. I can't speak to that, no analysis here and the time frame (the low carb thing was back around 2008) is too long for meaningful comparison. 2. Maybe? For normal things, not really, but when I try to row for an hour I feel it. I definitely get cold more easily. 3. I'm not built that way. The low carb thing was completely annoyance-free. As I said, the goal there wasn't weight loss, but raising my HDL; the weight literally came off by accident. Intermittent fasting doesn't bother me at all. Calorie restriction, which I generally do by A. going longer without food -- up to 2+ days; and B. eating less/less carb-rich/processed foods; can be somewhat unpleasant if I push it too hard, but I generally don't. Some days I'm feeling it (in a good way) so I go longer without food, some days I'm not, and I don't sweat which is which much. 4. Generally not a factor for me. 4.1. Definitely not a factor. Two times like I said, weight loss wasn't really the goal, so not relevant; and two times I hit the goal I set (last time), or went further (this time). 4.2 Doesn't really apply, since I've never been visibly overweight? Like, my waist has never been close to half my height. I'm tall, so the large numbers aren't as much of a factor. Regaining weight has never happened to me faster than about 10 pounds/year (just a guesstimate).

The interesting thing will be once I stop losing weight and start rowing again seriously, can I get back to a reasonable performance level. Fingers crossed...

Re: GLP-1 drugs: An economic disruptor? (2024)

#390

Post by esseph »

j_timberlake wrote: post #303
maleldil wrote: post #289

Earlier quoted context omitted.

> being overweight will be a choice Not everyone can take these drugs. Some people will have severe side effects. It's very common to have nausea, vomiting, etc., and some people will experience these frequently enough that the prescribing doctor will rescind the prescription.

Those side effects are from injecting weekly doses, right? I'm curious if daily oral doses which are smaller will solve a bunch of these problems at once, while also mitigating the supply-chain problems.

My wife was on daily doses and it made no difference. She's now having long-term problems, over a year after getting off of it.
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