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Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

fiercebiotech.com

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Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#381

Post by HWR_14 »

lettergram wrote: post #271
jjuel wrote: post #186

Earlier quoted context omitted.

Pretty sure we don't understand the long term risk of getting COVID either right? I mean it has not even been around for 2 years. Plus we do know it is possible only 1 infection would kill you.

That’s a straw man argument, when you take this drug you already have 100% covid19. Presumably that means you’ll have that risk, plus additional unknown risk. Perhaps the drug works like advertised, but we’ve seen better and more successful studies for things like ivermectin and anti-body treatments. Which have a known risk profile. It’s the same for the vaccine. You still have the risk of what ever the vaccine risk…

> Presumably that means you’ll have that risk, plus additional unknown risk.

That's a bad argument. This makes COVID less severe, which in turn makes the long-term affects less severe. Things in medicine are rarely binary.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#382

Post by warning26 »

mataug wrote: post #377
throwawaymedia wrote: post #337

Before everyone becomes super excited, I want you all to read this article from Nov 2: https://www.bmj.com/content/375/bmj.n2635 Read it carefully. Pfizer falsifies clinical data and covers up significant adverse effects. FDA knows about all of that and covers their asses. Whatever comes from Pfizer will be authorized without any questions being asked. It's not even a legislation, but a straight up internal arrangeme…

I understand this concern, but what can I as an average citizen do about this ? - Should we choose the moderna vaccine instead ? - Should we avoid the oral vaccine, and opt for the injection instead ? - Should we merely be skeptical and wait ?

My advice would be to avoid conspiracy theories on the internet and just live your life.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#383

Post by throwawaymedia »

mataug wrote: post #377
throwawaymedia wrote: post #337

Before everyone becomes super excited, I want you all to read this article from Nov 2: https://www.bmj.com/content/375/bmj.n2635 Read it carefully. Pfizer falsifies clinical data and covers up significant adverse effects. FDA knows about all of that and covers their asses. Whatever comes from Pfizer will be authorized without any questions being asked. It's not even a legislation, but a straight up internal arrangeme…

I understand this concern, but what can I as an average citizen do about this ? - Should we choose the moderna vaccine instead ? - Should we avoid the oral vaccine, and opt for the injection instead ? - Should we merely be skeptical and wait ?

I'm skeptical and I wait. I'll be the last one in line to take the shot. I'm a software engineer and I know that if you deploy a system to production RIGHT AWAY, something is gonna fail.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#384

Post by lightavalanche »

twofornone wrote: post #341
reureu wrote: post #259

Earlier quoted context omitted.

Ivermectin isn't a protease inhibitor though?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7996102/ Almost as if after clinical evidence (sure, arguably week) and a promising mechanism of action (yeah, in silico) a widespread, double blind RCT should have been conducted a year ago...

Another link: https://www.nature.com/articles/s42003-020-01577-x

Paxlovid and Ivermectin are both 3CLPro protease inhibitors.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#385

Post by VRay »

Loughla wrote: post #234
jasonpeacock wrote: post #213

Earlier quoted context omitted.

When hospitalization rates are down. In many metro areas the ICU are still full of un-vaccinated COVID patients, which means people with normal emergencies can't get a bed. Thus, COVID precautions are necessary to reduce the rate of infection to levels that do not overwhelm the healthcare system. And all those areas that have "returned to normal" are sending their COVID patients to regions that are still masking beca…

>And all those areas that have "returned to normal" are sending their COVID patients to regions that are still masking because they've exhausted their local ICU capacity. This has been my experience as well. My state is pretty strict overall, but my area of my state is not. Our hospital has been operating at capacity for 6 months or so, but nobody is talking about it. Because we can just ship to where they have stric…

It’s pretty amazing how stupid and shortsighted people are. We’re so good at overlooking the horrible situation we’re in and focusing on other things that are completely irrelevant

I used to think that one of the worst things in the USA was that 100 people per day die in preventable car accidents, but now we’re getting 10x that from a virus and people pretend that it isn’t happening

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#386

Post by DownGoat »

darthvoldemort wrote: post #307
wonderwonder wrote: post #290

Earlier quoted context omitted.

Interesting. From a quick google search: Pfizer brands include Advil, Bextra, Celebrex, Diflucan, Lyrica, Robitussin and Viagra You never take an advil?

Pfizer also made Celebrex, the anti-inflammatory that they knew caused health issues but they buried them and claimed it was safe. We are living in an upside down world now. All of a sudden the drug companies are the "good" guys. Since when did the drug companies suddenly become the heroes? https://corporatewatch.org/pfizer-six-scandals-to-remember/ 1986: Pfizer had to withdraw an artificial heart valve from the mark…

And if Pfizer fucked up the covid-19 vaccine, one of 20 other alternatives would gladly inform the public and remove a competitor from the market. That's the great thing about having so many alternatives for the covid-19 vaccine, all of them can gain an advantage by pointing out that a competitor's vaccine does not work.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#387

Post by ceejayoz »

throwawaymedia wrote: post #370
ceejayoz wrote: post #347

Earlier quoted context omitted.

One of Pfizer's trial vendors falsified information. https://www.cbs17.com/news/north-carolina-news/fact-check-re... > The Pfizer Phase III trial involved 44,000 people and 153 locations. From August 2020 through Sept. 17, 2020 — when she was fired — Jackson told CBS 17 that Ventavia accounted for at least 1,200 of those people and accounted for three sites. The author of the BMJ piece is quoted as saying “people are…

Quoted post unavailable.

If you open up the actual VAERS (https://vaers.hhs.gov/data.html), you'll see disclaimers like this:

> Reports may include incomplete, inaccurate, coincidental and unverified information.

> The number of reports alone cannot be interpreted or used to reach conclusions about the existence, severity, frequency, or rates of problems associated with vaccines.

The numbers are suddenly high, in part, because of this:

https://vaers.hhs.gov/faq.html

> Healthcare providers are required to report to VAERS the following adverse events after COVID-19 vaccination [under Emergency Use Authorization (EUA)], and other adverse events if later revised by CDC...

There's a COVID-specific reporting requirement on a previously optional system.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#388

Post by anonfornoreason »

bena wrote: post #304
dymk wrote: post #227

Earlier quoted context omitted.

Yeah, that’s the joke

It's a bad one. Because it only works if the numbers are the same across both states. But Missouri is doing better than Kansas. So unless the virus is somehow less contagious in Missouri, it seems like Kansas is just being an idiot in this case.

Depends on your metric. It’s perfectly reasonable to think that Kansas is doing better than Missouri because more people are able to lead the life they want.

There are other metrics beside “least fatalities” to factor.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#389

Post by AshamedCaptain »

AndrewBissell wrote: post #300
Server6 wrote: post #275

Earlier quoted context omitted.

It's fairly clear what the exit criteria is. Hospital capacity. When hospitals are filling up COVID measures are necessary. COVID is endemic now and will ebb and flow over the next decade. As such I would expect COVID measures to come and go based on local health department and hospital capacity needs.

It was a stroke of genius for the powers that be to convince people that they have a personal responsibility to restore/protect a health infrastructure that has been looted out, and structured if not designed to act in a predatory manner. They created new emergency powers and a new moral imperative to avoid contagious respiratory disease out of whole cloth. "Only You Can Prevent Forest Fires!"

Only you can prevent the dismantling of the health infrastructure!

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#390

Post by thehappypm »

It’s crazy that money is such a huge incentive. Knowing that a cure for Covid is a potentially $100B market means you throw the kitchen sink at it. Imagine being this lab. Do you think they ever had trouble hiring an assistant? Buying new equipment? Getting bonuses? This environment must be fantastically different from the typical meat grinder of bio R&D.
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