Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Moderna mRNA sequence released to GitHub [pdf]

github.com

Post reply on HN
Print view View original

381–389 of 389 posts

Re: Moderna mRNA sequence released to GitHub [pdf]

#381

Post by carlmr »

bobthebuilders wrote: post #180
carlmr wrote: post #65

Earlier quoted context omitted.

Maybe I'm thinking too simplified here, but wouldn't this only work on the first iteration? After all the virus would replicate with Us in your cells and then the replicas wouldn't have the advantage anymore.

By that point the cell would be producing the associated protein though. Getting it inside the cell is the goal here from what I've read.

But that's what I mean, viruses need to replicate. They do this by injecting their RNA into your cells and hijacking your ribosomes for their replication. So the first viruses would definitely get past your immune system, but the replicated viruses would then be produced by your cells, so they wouldn't have the U->psi replacement that the first generation had. So every subsequent generation of the virus could be fought by your immune system. Effectively giving the virus a head start of one replication cycle. I'm guessing this wouldn't change much. But I'm not a biologist.

Re: Moderna mRNA sequence released to GitHub [pdf]

#382

Post by peter303 »

mrfusion wrote: post #207
mlyle wrote: post #202

Earlier quoted context omitted.

> I have a "I'm sure that means something to somebody" feeling. Break it down! It's not so bad: > A composition A bunch of stuff > a messenger ribonucleic acid (mRNA) mRNA are cellular instructions on how to make proteins that are read by ribosomes that make those proteins as they read along. > an open reading frame This is something that starts with a "start codon" and ends with an "ending codon" and encodes valid i…

Why haven’t viruses or bacteria evolved to use a lipid nano particle to evade the immune system? Seems like a big security flaw in our cells?

Because some have. Phages for example.

Re: Moderna mRNA sequence released to GitHub [pdf]

#383

Post by peter303 »

One of Modernas cofounders, MIT Prof Robert Langer, was profiled on 60 Minutes a few years back as MITs most prolific patent holder. He specialized in nanoparticle delivery systems to any desired internal tissue. One can deliver medicine, nutrients, diagnostics, etc where and when they want. Vaccines are just a small of subset of these applications.

Re: Moderna mRNA sequence released to GitHub [pdf]

#384

Post by dnautics »

shadowofneptune wrote: post #372
nielsbot wrote: post #236

Earlier quoted context omitted.

It blows my mind to see how life (and death) work at the molecular level--it's almost like some kind of manmade machine, but far more subtle and complex.

These might interest you then: 3d visualizations of cellular processes in real time. I was shown them in my intro to biology class, which filled me with the same interest. Transcriptase: https://youtu.be/5MfSYnItYvg DNA polymerase: https://www.youtube.com/watch?v=bee6PWUgPo8 The Ribosome: https://youtu.be/TfYf_rPWUdY

I like the wehi videos because they take effort to make the molecular motions appear to be random, a result of stuff blundering about: https://youtu.be/7Hk9jct2ozY

Re: Moderna mRNA sequence released to GitHub [pdf]

#385

Post by ImaCake »

jonplackett wrote: post #299
shellfishgene wrote: post #286

Earlier quoted context omitted.

The sequence GATTCA appears 4 times in the reference version of the COVID genome :) (Go to https://www.ncbi.nlm.nih.gov/nuccore/NC_045512 , pick "Find in this Sequence" on the right)

AWESOME! I just did a text search for it on github. Maybe it didn't pick any up that had a line break in the middle. I'm much happier now.

Yep, the usual coding tools aren't ideal for bioinformatics. We have our own set of tools that work well with the various "standard" formats for sequence data.

Re: Moderna mRNA sequence released to GitHub [pdf]

#386

Post by calltrak »

Two rats were discussing the covid vax. One rat says to the other, hey are you going to get the covid jib jab? And the other rat replies. Are you completely mad in the head? Sure they have not finished with the testing and the human trials yet. https://brandnewtube.com has lots of eye opening information for those inquiring minds who have discerned that with regards to the covid story, something does indeed smell like a rat.

Re: Moderna mRNA sequence released to GitHub [pdf]

#389

Post by lettergram »

kickopotomus wrote: post #362
lettergram wrote: post #237

Earlier quoted context omitted.

Yes, that's one of the concerns many have about this technology. Literally, anything can be injected and done at this point. Not sure where the technology is exactly at, but I suspect we're no more than 5 years from major incident related to this. Even this vaccine, we really don't know the long-term impacts or risks involved with this. For instance, this vaccine does appear more risky than the standard flu vaccine:…

Do you happen to have a more verifiable source for your claim that COVID-19 vaccines are more risky than the flu vaccine? Excerpt from the disclaimer in your source: > VAERS accepts reports of adverse events and reactions that occur following vaccination. Healthcare providers, vaccine manufacturers, and the public can submit reports to VAERS. While very important in monitoring vaccine safety, VAERS reports alone cann…

Give the incentives no, however it should be noted VAERS is only going to undercount not over count. Physicians are required to fill it out if there’s adverse side effects at the hospital.

Wish there was more but the incentives aren’t really aligned for open research on this.

We can get the real cdc idc10 (billing) results in several months.

Post reply on HN