An hour of exercise in the morning for me has the same effect as the described effects of the drug.
I get by with 30 minutes every day. It would seem the more consistent the routine, the less the cravings at 11pm.
GLP-1 drugs: An economic disruptor? (2024)
361–370 of 553 posts
Re: GLP-1 drugs: An economic disruptor? (2024)
#362I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…
How did you get it? I've wanted something similar.
Re: GLP-1 drugs: An economic disruptor? (2024)
#363Earlier quoted context omitted.
It's not silly at all. In 15-20 years this stuff will be <$100 for weeks of use. For many people $800 dollars is less than the they spend on food in the same time
Yup. The current retail cost in Canada is ~$160 USD per syringe for Ozempic.
How much is Wegovy?
Re: GLP-1 drugs: An economic disruptor? (2024)
#364[flagged]
Re: GLP-1 drugs: An economic disruptor? (2024)
#365Earlier quoted context omitted.
The destructive behavior is overeating and this treatment eliminates the overeating. The problem is human beings are imperfect creatures. This drugs corrects the hormone imbalance that leads to overeating. It is fixing the actual problem. The idea that medical treatment makes us weaker is genuinely harmful nonsense on the order of claiming vaccines make us sick, and you should seriously reconsider your position here.
Where did these hormone imbalances come from, when and why did they arise, why aren't they uniformly distributed across the globe? Answering these questions may lead to a root cause of obesity and obviate the need for medication altogether.
Do you believe overeating to not be the equivalent of depression, schizophrenia, addiction, or bipolar disorder requiring medical intervention? If so, why? This is brain chemistry.
Re: GLP-1 drugs: An economic disruptor? (2024)
#366Earlier quoted context omitted.
Where did these hormone imbalances come from, when and why did they arise, why aren't they uniformly distributed across the globe? Answering these questions may lead to a root cause of obesity and obviate the need for medication altogether.
Do you believe overeating to not be the equivalent of depression, schizophrenia, addiction, or bipolar disorder requiring medical intervention? If so, why? This is brain chemistry.
Suppose a country had very low rates of depression, and another had very high rates. Is that just brain chemistry? Or does maybe one country have problems that cause many people to have depression? Or to push subclinical tendencies into clinical territory?
The US is that but for obesity. Yes, absolutely some individuals have brain chemistry that predisposes them to this.
But also maybe it's related to the cheapest and easiest forms of food being McDonald's-tier shit and 64oz beverages that are literally so much sugar that it would be unpalatable were it not dissolved in acid and carbonated?
Re: GLP-1 drugs: An economic disruptor? (2024)
#367I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…
I am 8 months in, you do develop a tolerance over time to the drug (and why you need to increase the dosage progressively). I have gone up slower than the prescibed steps but still, this drug is to help doing diets, I don't think it would work as a long term medication. And as far as I can tell, when you get off the drug or have become tolerant to the current dosage, it is easy to gain back some weight if you are not…
"I don't think it would work as a long term medication"
It seems like there is a lot of disagreement on this very basic point. Surely there must be data from the decade or so it was prescribed for diabetes.
Re: GLP-1 drugs: An economic disruptor? (2024)
#368Earlier quoted context omitted.
Do you believe overeating to not be the equivalent of depression, schizophrenia, addiction, or bipolar disorder requiring medical intervention? If so, why? This is brain chemistry.
Suppose a country had very low rates of depression, and another had very high rates. Is that just brain chemistry? Or does maybe one country have problems that cause many people to have depression? Or to push subclinical tendencies into clinical territory? The US is that but for obesity. Yes, absolutely some individuals have brain chemistry that predisposes them to this. But also maybe it's related to the cheapest an…
https://data.worldobesity.org/rankings/
https://www.who.int/activities/controlling-the-global-obesit...
The US isn’t even the top 9. Obesity is a global epidemic of Western disease. The food isn’t the cause, it’s the symptom of the brain chemistry. If it isn’t available, yes, the disease may not present. But if available, due to hormones causing the drive, it presents. Like cigarettes (nicotine), like cocaine, like alcoholism. Same reward center.
https://recursiveadaptation.com/p/the-growing-scientific-cas...
Are we more likely to give GLP-1s to everyone? Or outlaw calorie dense, nutrition lacking products? I argue the former, based on all available evidence.
Re: GLP-1 drugs: An economic disruptor? (2024)
#369Earlier quoted context omitted.
No brain fog. I walk at a very brisk pace ~6 miles a day. My calories are far less than before I started. I have to be very careful to have enough protein. When I exert myself, the recovery period is the same time as before.
Do you have any idea of how many calories you eat per day? I get so confused because the small amounts of food that people talk about eating on GLP, don't seem like enough to sustain themselves long-term. Are they exaggerating? Or do they talk about not eating dinner, but that's because they had 1,700 calorie lunch at the burger place? Or is that just during weight loss, and then once a target weight is hit, they're…
> I just genuinely don't understand how people are surviving with the diets they describe.
Because obese folks have stored energy reserves. The body is really good at adapting and using them.
I was attempting to be at a 1k/day calorie deficit during my peak weight loss phase. I typically met or beat this target, usually eating around 1200-1600 calories/day plus a lot of walking - 25k steps/day minimum as an absolute non-negotiable. I'd check my step counter before bed, and put pants back on and go for a "midnight" walk if I was under my count for the day.
The first few weeks were quite hard, but it was pretty smooth sailing after that. Lots of naps. After that I was tired some days, but not overly so. I peaked at about 30lbs/mo weight loss for ~3 months, then tapered off to 5-10lbs/mo for my final 30ish I had to lose.
I don't really suggest anyone else attempt to "crash" their program like I did - but it's how my brain operates. I need immediate and obvious results, and those turn into a feedback loop for me. Being a bit more tired each day was perfectly acceptable for the goals being achieved.
That said - I wish I had started resistance training when I started my dieting program. I took it up at the very end of my weight loss, and it took me about 9mo to get back to roughly the same lean muscle mass as I had before I lost weight. I'm still working on min/maxing body comp about 18mo later.
The best weight loss program is the one that works for you. Pretty much full stop. It's going to be highly individualized. Some folks will do much better with a small deficit for a few years, but I know from experience that would never work for me.
I think a lot of the stuff you see on-line about "forgetting to eat dinner" is exaggerated and folks starting off on the drugs being amazed at it. Very few people will post a "well, I'm a bit less hungry" type of result. Everyone I know on them eventually became somewhat habituated to this sort of effect, but everyone is highly different. For me, I considered Tirzepatide a performance enhancing drug for my diet. I still went to bed hungry most nights - it was just far easier to chain together days and weeks of doing so on the drug vs. off. It still took a lot of willpower and habit building for me to pull it off at that level.
Re: GLP-1 drugs: An economic disruptor? (2024)
#370Big food corporations profit from ultra-processed foods that manipulate our natural systems. They design products that override satiety signals using calculated combinations of sugar, fat and salt to activate brain dopamine pathways. Their priority is profit growth, not consumer health. The consequences are significant health issues like obesity, diabetes and cardiovascular diseases. Healthcare systems struggle with…
GLP-1 drugs also manipulate our natural systems. It's not a panacea. There are early indications of increased suicidal ideation in cohorts that take this drug. Caveat emptor