Hi,

sorry for the late reply. Had to get back to my contacts re your questions. I did not check or ask for reference / primary data sources, but I was talking to medical doctor directly involved in the German SARS-CoV2 vaccination program on a local level.

> Is that with AZ or an mRNA vaccine?

It seems to be unclear by now which combination of vaccination dosages (and their timing) gives the best results. When it comes to double shots, I was told that

- AZ: 1 in 5 get infected

- Biontech: 1 in 20 get infected

> Also by "problematic", do you know if they meant WHO's "mild" or "severe"? "Mild" is still quite bad, just not enough to hospitalize you.

Unfortunately, I did not ask regarding these specifics, but I believe that the wording was according to WHO standards.

According to my source, after two shots:

- AZ: 90% less severe cases, 85% less infections

- Biontech: 85% less severe cases, 95% less infections.

So, statistically speaking, AZ is better to avoid bad cases, while Biontech is better for spread.

In southern Germany, it seems that there is increased activity in administration a combination of both vaccines. This is done because there seems to be an indication that a combination might be better than a mono-vaccine, and/or because of the supply situation / available vaccines.

There is a meta study coming out in the UK regarding AZ/Biontech/Moderna vaccine combination and vaccination timing effects.

Hope it helps a bit.