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Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

gavi.org

351–360 of 393 posts

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#351
post #344

Earlier quoted context omitted.

Gotta love the logic of telling adults not to get the vaccine because its probably too late and you're already infected, while also telling parents not to give it to their kids because it's only for "prostitutes and promiscuous gay men" (per RFK)

I believe you are referring to comments made about the hepatitis B vaccine, not HPV.

That's right; that particular HHS Secretary comment was about Hepatitis B.

> "“Hepatitis B vaccine was made for prostitutes and for promiscuous gay men,” Kennedy said in an interview on his Children’s Health Defense show in 2022."

https://www.washingtonpost.com/health/2025/06/25/rfk-jr-vacc...

The WaPo article doesn't bother to refute RFK's lies, but here's /r/medicine responding to them (in the context that's topical this week—RFK ordering the removal of the Hepatitis B vaccine from the children's schedule):

> "Let's be even more clear about this. If you contract Hep B in the first year of life, more than 90% develop the chronic form, and the need for liver transplant is much higher.... Worldwide, the second most common route for children under 5 to catch HBV is from other children, and that's not by doing IV drugs or having sex. (First most common is vertical, through mother.)"

https://old.reddit.com/r/medicine/comments/1niml9d/kennedys_...

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#352

Earlier quoted context omitted.

>I'd rather take my chances with the actual disease at this point.. Gross, @DaSHacka. Absolutely vile.

Not as vile as having sex with someone who's already infected, whether protected/vaccinated or not.

In a world of perfect information, you might have a point.

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#353
post #270

Earlier quoted context omitted.

Also after some research about rate of change: It's extremely slow. HPV is a double-stranded DNA virus with very high replication fidelity. The emergence of types like 16 and 18 happened hundreds of thousands of years ago. I did know it was quite slow but not just how slow. Very long term vaccine efficacy is expected.

Not anti-vax by any means, but it's not too conclusive to use past mutation rate here because the presence of a vaccine targeting successful strains introduces a strong evolutionary pressure for the more rapid emergence of novel strains in the future.

It's not just the past empirical observed rate, it's the type of virus it is/other things that we know about it.

On top of being structurally a dsDNA virus which doesn't change much, HPV is subject to "purifying selection": because of the way it is built and the mechanism it uses to interact with host cells, it is very difficult for it to have productive mutations that don't immediately die out. It's highly constrained in a way that eg influenza, COVID, HIV, are not.

Some pathogens are just easier to deal with than others:

We have been curing syphilis since 1943 with just penicillin. It doesn't develop resistance because it doesn't have horizontal gene transfer and the mechanism it has that penicillin targets is too critical and conserved, it just can't mutate away from it.

Polio mutates quickly, but is extremely constrained, almost all mutations are defective, and the capsid structure is highly conserved. That vaccine has been in use since 1955 without losing effectiveness or introducing new variants.

The biology of HPV says it will be more like those cases, and since the introduction of the vaccine in 2006, that's what studies have been finding empirically.

To emphasize the difference in meaning of "strain" for HPV: There are 200+ HPV genotypes that have been numbered this way, but they are all of ancient origin. There are observed shifts in prevalence of different genotypes, but not newly evolved genotypes.

We also only care about targeting oncogenic strains. If we open up selective pressure for non-oncogenic strains to be more relatively successful and take over, great.

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#354
post #147

Earlier quoted context omitted.

It is actually not straightforward to do. Safeway Pharmacy refused to actually give me the vaccine when I showed up saying I'm not in a group that's eligible. One Medical told me that it would be a $400/shot 3-shot regimen. I'll probably just travel to India some time to visit family and get Cervavac there instead of Gardasil here. It's about $20/shot.

The Walgreens pharmacist scolded my 35 year old girlfriend for getting it, saying that it was useless at her age. She insisted and he reluctantly administered the first dose (and later got the rest at another location). He even questioned her motives for getting it once she was in the room. I was appalled by the whole interaction. Maybe I could have understood if I had said she was my wife. But it is still stupid to…

I'm 44 and didn't catch any gruff from the staff. I'd complain to the head pharmacist.

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#355
post #280

Earlier quoted context omitted.

This is not true any more. The vaccine has been shown to lower cancer risk for those who already carry the virus, so it is recommended even for people who are HPV positive

That's interesting and I would like to take, can you give me a link/ ref for citation?

This is a totally predictable result, there are dozens of HPV strains and the vaccine will immunize against 9 of them that are high risk.

So, unless you are a sex worker or similar, it's unlikely you "have" all of them to the point where the vaccine is completely useless. You might later get infected with a strain that you didn't yet have, and it's precisely the one that kills you.

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#356

Earlier quoted context omitted.

It's not approved for those over 45. (AFIAK, simply because so few people in that age group would have risk without having had prior exposure. Basically only those who had divorced or lost their long time partner.)

This is not true any more. The vaccine has been shown to lower cancer risk for those who already carry the virus, so it is recommended even for people who are HPV positive

so how would one in the US go about getting it? gardasil?

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#357

Earlier quoted context omitted.

It's not approved for those over 45. (AFIAK, simply because so few people in that age group would have risk without having had prior exposure. Basically only those who had divorced or lost their long time partner.)

That feels like a wild assumption to me - we really think people 45+ aren't having casual sex? less casual sex maybe, but I would imagine still a decent amount, statistically.

The original criteria was for people who had not already been exposed.

And over 45s that engage in casual sex have almost certainly been exposed. Those who don't have prior exposure probably have few or one partner in a marriage or marriage-like situation and thus are not likely to be exposed. Yes, they could be cheated on or the like but exposure is not expected so effectiveness can not be measured.

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#358

Earlier quoted context omitted.

If you’re having casual sex at 45+ you probably already carry HPV.

Or, you could have been suddenly cheated on and exposed, or divorced and recently entered the dating market, or thinking about opening up your relationship after decades of monogamy.

But the number of such people is low, it would not be easy to find candidates for the trial. Just because there are some doesn't mean there are enough to make it worthwhile for the drug company to do the testing to be able to market it to such groups.

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#359
post #171

Earlier quoted context omitted.

This is very different from recommending horse dewormer; if you can't tell the difference, I'm sorry.

Ivermectin is also used by dermatologists to fight face parasites that cause bad acne.

Ivermectin is also used to treat COVID in countries that have endemic parasite outbreaks. COVID responds well to steroids, but so do parasites. Giving steroids to someone with parasites causes the parasites to become much stronger, and trigger reactions from the immune system: fever, etc.

I ideally you could test for parasites, but time and resources don't allow for that in many countries. So if it's generally safe to just give ivermectin along with steroids when treating COVID - in countries where parasites are common.

Maybe I'm wrong about this. Maybe I'm making it up. Don't listen to what I say. Listen to your doctor.

Re: Denmark close to wiping out cancer-causing HPV strains after vaccine roll-out

#360
post #308

There is recent research showing that it can (slightly) help even during HPV infection, see "Effect of HPV Vaccination on Virus Disappearance in Cervical Samples of a Cohort of HPV-Positive Polish Patients", J Clin Med (2023) https://pubmed.ncbi.nlm.nih.gov/38137661/ . Also, the eligibility criterion of not vaccinating people above certain age is NOT valid. I mean, sooner better. But if you are adult and there is any…

> any chance that you ever get a new sexual parter, get a vaccine.

Not only that - I learned recently that you can contract certain strains from a shower floor [1]

[1] https://dermnetnz.org/topics/non-sexually-acquired-human-pap...

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