Earlier quoted context omitted.
Use Equalizer APO with a noise-reduction VST. This is by far the best option on Windows if you are concerned about latency×compatibility×underruns as a figure of merit. It is far superior to using "virtual audio cables" and a VST host (like Lighthost or SAVI) or voicemeeter. It's not well known, but it really works spectacularly well compared to those other options. For me it never has had any audible buffer underrun…
What VSTs would you recommend for improving audio quality of video calls?
Some general EQ'ing on the mic also works wonders for how well it sounds, but that's very specific to your voice and mic.
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Another use case of Equalizer APO where it is much better than everything else is compressing game audio. Some games simply have audio that was designed without regard for hearing safety (CS:GO is a strong contender for #1 here), and this helps immensely with it.