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Peptides: where to begin?

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Re: Peptides: where to begin?

#341

Post by cjbgkagh »

aeonik wrote: post #206
ramraj07 wrote: post #168

Earlier quoted context omitted.

Im sorry for your quality of life problems but calling doctors bad at statistics and then giving anecdotal evidence as proof has to start ringing some logical bells right? You dont even have to take our word. Use an LLM as judge. Paste your comment into chatgpt and see what it says.

I didn't read their whole comment, but I worked in the Internal Research department of a medical school. I did their statistical studies and built software for analysis pipelines. Doctors, at least 15 years ago, were definitely bad at statistics. They were not required to take a statistics course at all . Most programs would require Algebra and Calculus as part of their science reqs. Some would maybe take one basic r…

I’ve not only visited many doctors personally I was also part of a team working on a medical diagnostic instrument, the result of the instrument was a probability distribution function and it was impossible to explain this to the doctors who really would only accept a small number discrete classifications, which in effect throws out about half of the data we had worked so hard to collect.

Re: Peptides: where to begin?

#342

Post by TeMPOraL »

tekla wrote: post #323
steveBK123 wrote: post #312

Earlier quoted context omitted.

Mandate vs interest. Compare how seriously many SWEs take mandatory HR/compliance trainings vs hanging out on HN, taking online courses, arguing about code, trying new frameworks, coding in spare time, etc.

HN SWE's rarely do anything important. Doctors generally do.

Also doctors go to conferences and usually like doing it.

Re: Peptides: where to begin?

#343

Post by TeMPOraL »

allador wrote: post #328
arjie wrote: post #213

I used retatrutide for weight loss and went from 199.3 lbs to just under 175 lbs. I kept daily notes through the process. Here's a quick AI one-paragraph summary if you're curious: https://pastebin.com/XACNYKvs Overall I'm quite pleased with the effects and many of the properties of this treatment that people dislike are actually properties I was looking for. Essentially, for pharmacological interventions I want impe…

Please be careful here, as Retatritude is not actually commercially available in most of the world, outside of research labs. And is not FDA approved to buy or use in the US (where most of HN readers are). I fear this kind of post will encourage gullible people to go chasing reta on the grey market, where they might as well be getting a placebo, as there's no mechanism for your typical person to verify that they're g…

> there's no mechanism for your typical person to verify that they're getting what they think they're getting.

Think what would happen if there was one.

In the spirit of selling shovels in a gold rush, the first company to commercialize a tricorder is going to make bank off all the fitness fads and off-label/DIY medicine markets.

Re: Peptides: where to begin?

#344

Post by cjbgkagh »

dotancohen wrote: post #151
cjbgkagh wrote: post #65

Peptides are a revolution and you don't need to know how they work to know that they work (for various people for various conditions). There is a tension between empiricism and fundamentalism with much of medical science focusing on fundamentalism. Now with the ability to collect and search large amounts of empirical data and communicate it peer-to-peer people are picking up on a lot of things that work without knowi…

> Peptides are a revolution and you don't need to know how they work to know that they work Perhaps. But knowing the mechanism of how they work sure seems fundamental to ensuring that they are safe to use.

If a lot of people take the mediation and die is that evidence that the medication is unsafe? If they live is that evidence that the medication is safe? Either both are true or neither is true. The relative weight of evidence is dependent on priors but it is still evidence.

Re: Peptides: where to begin?

#345

Post by kube-system »

Bender wrote: post #280
kube-system wrote: post #9

Earlier quoted context omitted.

The regulation of drugs or most any consumer product is not due to the inherent danger of an item itself, but the danger presented to a consumer inside the context of societal mechanisms that influence behavior. You're right that many regulations don't make sense outside of a societal context -- but that's because they also don't exist outside of a societal context. The reason we don't need tight regulations on bleac…

The reason we don't need tight regulations on bleach is because we don't have a societal issue causing people to drink it and hurt themselves.. I think you missed out on a long time period of 4chan. They managed to get a number of people to mix ammonia and bleach.

More people do this accidentally trying to clean something than have ever done it because 4chan told them to. Still, the incidence rate is low.

Re: Peptides: where to begin?

#346

Post by littlestymaar »

throwaway2037 wrote: post #252
JumpCrisscross wrote: post #139

Earlier quoted context omitted.

> hamburgers and milkshakes don’t give you heart disease and cancer They absolutely do, particularly if you're getting most of your calories from them. If evidence-based medicine doesn't convince you, uh, hamburgers and supermarket milk tends to be processed.

I agree 100% with your follow-up. In the last 30 years of medical research, I do not recall anything but negative health results from eating red meat (beef). The real culprit is saturated fat. It is the cigarettes of food. There is almost no healthy level to consume, so keep it to 20g per day or less. Reading this chain of responses from the original is making my internal bullshit alarm (Brandolini's law) go "wee woo…

> The real culprit is saturated fat. It is the cigarettes of food. There is almost no healthy level to consume

Not at all an expert, but from what I understood saturated fat isn't particularly good but it's not “no healthy level to consume” either (fortunately because you practically cannot avoid them).

I think you're confusing them with trans-insaturated fat (which I don't think are as bad as cigarettes either, but are still bad).

Re: Peptides: where to begin?

#347

Post by mapontosevenths »

ifyoubuildit wrote: post #313
mapontosevenths wrote: post #286

Earlier quoted context omitted.

> That said, the issue for many is autonomy Your right to swing a fist ends where the other fella's nose begins. That doesn't mean you aren't free, it just means you recognize that the right not to suffer grievous bodily harm trumps the right to swing your fist willy-nilly. As a fist-swinger you may not always agree, and you may even get hurt one day because you couldn't swing your fist whenever you wanted, but that'…

[flagged]

I appreciate why you might feel that way. It's reasonable for reasonable people to disagree, but in this case the experts we trust to decide these things decided that you were the one who presented a danger to society. I seriously doubt that you have the sort of medical credentials that would be required to get any serious person to take your word over those of the world class epidemiologists, virologists, etc who said the opposite.

Regardless of correctness though, even if they'd been wrong it's just part of life that sometimes you have to go along to get along. There are a lot of things I disagree with society about, but I depend on society to live. It would childish to try not to participate.

Re: Peptides: where to begin?

#348

Post by Bender »

kube-system wrote: post #345
Bender wrote: post #280

Earlier quoted context omitted.

The reason we don't need tight regulations on bleach is because we don't have a societal issue causing people to drink it and hurt themselves.. I think you missed out on a long time period of 4chan. They managed to get a number of people to mix ammonia and bleach.

More people do this accidentally trying to clean something than have ever done it because 4chan told them to. Still, the incidence rate is low.

Maybe so. Still one would be amazed at how many people will follow extremely dangerous and dumb trends on the interwebs. Don't get me wrong, I see it as just a small part in the great filter much like I think we should remove all warning labels.

Re: Peptides: where to begin?

#349

Post by aeonik »

cjbgkagh wrote: post #341
aeonik wrote: post #206

Earlier quoted context omitted.

I didn't read their whole comment, but I worked in the Internal Research department of a medical school. I did their statistical studies and built software for analysis pipelines. Doctors, at least 15 years ago, were definitely bad at statistics. They were not required to take a statistics course at all . Most programs would require Algebra and Calculus as part of their science reqs. Some would maybe take one basic r…

I’ve not only visited many doctors personally I was also part of a team working on a medical diagnostic instrument, the result of the instrument was a probability distribution function and it was impossible to explain this to the doctors who really would only accept a small number discrete classifications, which in effect throws out about half of the data we had worked so hard to collect.

Yes! good point, I have noticed this as well.

You reminded me about another idiosyncrasy: Doctors are addicted to double blind randomized control trials.

Which yes, those are powerful. But good evidence can come from many other study designs. Especially when mechanisms and first principles are being studied.

Re: Peptides: where to begin?

#350

Post by kube-system »

JumpCrisscross wrote: post #141
kube-system wrote: post #33

Earlier quoted context omitted.

Pfft -- they're common among anyone over 30 who exercises!

> they're common among anyone over 30 who exercises They shouldn't be. If someone has chronic tendon or joint issues, that's something to discuss with a doctor and a trainer.

I think we are, and I'd presume that's why sports medicine centers are so common.
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