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GLP-1 drugs: An economic disruptor? (2024)

wildfirelabs.substack.com

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Re: GLP-1 drugs: An economic disruptor? (2024)

#341

Post by glp1guide »

jijji wrote: post #338
macintux wrote: post #3

Interesting, but I’m not sure I buy it. I certainly don’t think Simon is preparing for this massive economic shift; I think they’re reacting to an existing trend. > America's largest mall operator, Simon Property Group, is converting anchor stores into medical centers and wellness spaces. They're doing this because they recognize the writing on the wall. Malls have been dying for years, and COVID felt like the nail i…

In October of 2023, when Walmart CEO told Bloomberg [0] that ozempic was partially responsible for sales declining, other shares including Coca-Cola [1] started to fall as well.... [0] https://web.archive.org/web/20231006122607/https://www.bnnbl... [1] https://www.marketwatch.com/story/coca-cola-and-pepsicos-sto...

I think this is the appropriate response — it’s clear that lack of appetite control is driving purchases a nontrivial amount of the time for junk foods — companies that depend on that revenue have never really had a challenge until now

Re: GLP-1 drugs: An economic disruptor? (2024)

#342

Post by glp1guide »

wakawaka28 wrote: post #270
cedws wrote: post #104

Earlier quoted context omitted.

There are some signs that these drugs have effects beyond just apetite supression leading to weight loss. I recall reading something about them having a direct slowing effect on the metabolism, which increases longevity, among other benefits. I can foresee it being used like a supplement among those who can afford it.

It will probably fuck up your body in ways that we can hardly imagine. Ozempic has been linked to lots of horrible side effects.

No it hasn’t— its well researched and the short to mid term (ish) side effects are well known:

https://glp1.guide/tag/category-side-effects/

Re: GLP-1 drugs: An economic disruptor? (2024)

#343

Post by thisisnotauser »

appleorchard46 wrote: post #334

Obesity causes many health problems, but it's also a symptom - of our poor relationship with food, of the way American society is set up around instant gratification, of the predatory nature of food manufacturers. Though treating the symptom is undeniably good, it also lets the deeper problems that lead to it go unchecked, and my fear is that it will lead to novel problems down the line. How recreational drugs are be…

The destructive behavior is overeating and this treatment eliminates the overeating. The problem is human beings are imperfect creatures. This drugs corrects the hormone imbalance that leads to overeating. It is fixing the actual problem.

The idea that medical treatment makes us weaker is genuinely harmful nonsense on the order of claiming vaccines make us sick, and you should seriously reconsider your position here.

Re: GLP-1 drugs: An economic disruptor? (2024)

#344

Post by jijji »

gibspaulding wrote: post #296
Earw0rm wrote: post #88

The article posits that 80% of the top income quintile will be on this medication. I have to ask, why? (I'm not in the US, I should add). Like, sure, is the average American overweight? Yes. Are 80% of the top 20% of earners? Seems pretty doubtful, plenty of the rich look to be in reasonable shape. That statistic suggests that 80% of successful people have such poor impulse control that they end up seriously overweig…

> if there were a GLP1 for procrastination Adderall?

Guanfacine? Atomoxetine? safer, non-narcotic (not on a Schedule), non-habit forming, non-stimulant medication for attention deficit disorder (ADD)

Re: GLP-1 drugs: An economic disruptor? (2024)

#345

Post by glp1guide »

Earw0rm wrote: post #88

The article posits that 80% of the top income quintile will be on this medication. I have to ask, why? (I'm not in the US, I should add). Like, sure, is the average American overweight? Yes. Are 80% of the top 20% of earners? Seems pretty doubtful, plenty of the rich look to be in reasonable shape. That statistic suggests that 80% of successful people have such poor impulse control that they end up seriously overweig…

> Admittedly if there were a GLP1 for procrastination, I'd be on that stuff like a shot...

This might be my biggest unknown with GLP1s, how does it affect people with reward system issues — it could dramatically worsen a procrastination problem if it dampen the will to reward seek.

Then again it has only seemed to do this for vices so far

Re: GLP-1 drugs: An economic disruptor? (2024)

#346

Post by thisisnotauser »

LostMyLogin wrote: post #331
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

> being overweight will be a choice (choosing not to take the drug) This may be an ignorant take and if it is I apologize, but isn't it a choice anyway? A calorie deficit and minimal exercise will have you cutting body fat. Or am I missing something here?

It's possible your personal experience with food is different than other people's, and it is easier for you to make that choice than others.

Re: GLP-1 drugs: An economic disruptor? (2024)

#347

Post by aaronblohowiak »

LostMyLogin wrote: post #331
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

> being overweight will be a choice (choosing not to take the drug) This may be an ignorant take and if it is I apologize, but isn't it a choice anyway? A calorie deficit and minimal exercise will have you cutting body fat. Or am I missing something here?

People aren’t computers. Eating fixation and compulsion empirically override the more rational mind in millions of people. One of the effects of these drugs is making eating a more “impersonal” or “detached” kind of decision, so it feels like a real choice rather than something that you think you have a say in but really the more base instincts will override.

Re: GLP-1 drugs: An economic disruptor? (2024)

#348

Post by SimianLogic »

Earw0rm wrote: post #88

The article posits that 80% of the top income quintile will be on this medication. I have to ask, why? (I'm not in the US, I should add). Like, sure, is the average American overweight? Yes. Are 80% of the top 20% of earners? Seems pretty doubtful, plenty of the rich look to be in reasonable shape. That statistic suggests that 80% of successful people have such poor impulse control that they end up seriously overweig…

I think the point was that 80% would have insurance coverage, not that everyone would take it.

Re: GLP-1 drugs: An economic disruptor? (2024)

#349

Post by valunord »

homebrewer wrote: post #327
valunord wrote: post #254

Earlier quoted context omitted.

Thanks for experimenting with your body. I'll be sure to check back in about ten years to see how all this shakes out. Keto + intermittent fasting are my magic pill right now and have been for some years.

I'm pretty sure keto has not been extensively studied for anything but the management of epilepsy in children that do not respond to medication. So tbh this is an odd comparison.

Keto and such diets have been used for millennia. Our bodies are MADE to use keto... Lol.

Re: GLP-1 drugs: An economic disruptor? (2024)

#350

Post by IncreasePosts »

brokensegue wrote: post #26
aljgz wrote: post #14

> When companies like Google see their healthcare costs drop by $12,000 per employee annually and productivity increase by 25%, we observe a restructuring of corporate America that makes remote work a minor adjustment. In my entire office, there's one overweight person that I know. Out of thousands of employees. There could be more, and other cities might be different, but you get the idea. The author intentionally o…

40% of Americans are obese and way more are merely overweight. Either your office is small, a huge fluke, weirdly selected or you're not observant enough.

Well, here in boulder, there are a lot of tech workers, and it is one of the thinnest cities in one of the thinnest states. Having said that, Colorado in 2025 despite being one of the thinnest states is still fatter than the fattest state in 1990.
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