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Moderna mRNA sequence released to GitHub [pdf]

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341–350 of 389 posts

Re: Moderna mRNA sequence released to GitHub [pdf]

#341

Earlier quoted context omitted.

People tend to think of genetic code as a sort of assembly language which is very verbose, but I wonder if the correct way to view it is in fact a very terse domain-specific language, because it actually depends on the entire complex machinery of the cell to be present in order to work, which in itself contains a lot of information?

Yes. Another important metaphor is that the common idea of DNA as blueprints is entirely wrong. It's not blueprints, it's a recipe. A blueprint describes what something is. A recipe describes the steps needed to make something, making use of a lot of complex existing machinery and parts with only a reference to them.

The nucleotide sequence is obviously important, but people also sometimes forget that DNA and RNA are real things with 3D structure too. That matters too: it’s as if builders make errors where the blueprint rolls up or pages stick together.

The whole thing is absolutely fascinating and wild.

Re: Moderna mRNA sequence released to GitHub [pdf]

#342

Earlier quoted context omitted.

Wouldn't the "compiler" be the bioreactor used to mass-produce it and the "installer" be the lipid encapsulation? :)

Maybe the booster shot can be done with a simple apt-get update.

Serious. Unless it requires a separate, native-compiled adaptive immunity package.

Re: Moderna mRNA sequence released to GitHub [pdf]

#343

Earlier quoted context omitted.

Maybe the booster shot can be done with a simple apt-get update.

Got the “GPG Error: No Public Key” error. Probably for the best!

Fawwwwwk. Gotta edit the /etc/apt/apt.conf.d/covid-19-vaccine.conf

Anyone know if sudo works?

Re: Moderna mRNA sequence released to GitHub [pdf]

#344
post #89

Earlier quoted context omitted.

InstallGene by Flexera

Just waiting for first copy protection mechanism for mRNA. SafeGene and SecuGene here we come :o

"The authorization server is down, no longer signing this version of this medication, or this medication has expired. Please contact your supplier for more information."

Shit, I'm going to have to google for a working hex edit or look for a bpatch.

Re: Moderna mRNA sequence released to GitHub [pdf]

#345

Earlier quoted context omitted.

Just waiting for first copy protection mechanism for mRNA. SafeGene and SecuGene here we come :o

Can you imagine, the greedy folk would want some sort of Widevine in humans.

"Drink Brawndo, The Thirst Mutilator." in your DNA too.

Sony is gonna sneak in some DRM and Mark Russinovich is gonna put out a fix.

Re: Moderna mRNA sequence released to GitHub [pdf]

#346
post #89

Earlier quoted context omitted.

InstallGene by Flexera

Just waiting for first copy protection mechanism for mRNA. SafeGene and SecuGene here we come :o

Can't wait for the DNA "chip art" by gene designers. Considering we have so much HERV, they might use that as an equivalence rationalization to do it.

Re: Moderna mRNA sequence released to GitHub [pdf]

#348

Earlier quoted context omitted.

I'm estimating roughly 90-ish characters in a row, roughly 40 rows encoding the spike protein. So about 3600 base pairs. There are 3 base pairs per amino acid, so That's 1200 amino acids. For comparison, the smallest chain that they technically call a protein is 100 amino acids that's an arbitrary limit to separate proteins from enzymes. So this thing isn't tiny tiny. But Titin (also called connectin), a giant protei…

> that's an arbitrary limit to separate proteins from enzymes Do you mean “to separate polypeptides from proteins”? Enzymatic activity has nothing to do with size. For example, one of the smallest enzymes in humans has 62 amino acid residues. And, under certain conditions, even single amino acids can be catalytic. But yeah, the polypeptide-protein threshold can get fuzzy, especially with the recent advances in minipr…

yes, that is what I meant. It's been a long time since I've used that info.

The story I remember was that Insulin was the first protein that was sequenced, which is funny because it was before they made the distinction. It's actually too small to be considered a protein now.

Re: Moderna mRNA sequence released to GitHub [pdf]

#349

Earlier quoted context omitted.

Sure, but if you took that 30k of data and dropped it on a planet just like earth it would still take 10k years or so for us to build civilizations as we know it again.

Not 10k year as it needs to go through the million years scale - rna, hot, uv then dna ... with no oxygen to oxygen etc. Then million of years of evolving ... scale is a bit off.

He's saying if you wiped out human civilization it would take O(10k) years to rebuild, because knowledge/culture isn't stored in the genes.

Re: Moderna mRNA sequence released to GitHub [pdf]

#350
post #243

Earlier quoted context omitted.

> It's an interesting structure... I think that's the question. I'm very much used to reading "A machine-readable medium, comprising..." I'm curious what bits are unique to COVID-19, and what bits are generally protecting the idea of using a carrier to send a specific protein. In this case, is it the "S" protein phrasing that protects the specific embodiment of COVID19's spike?

Here what is claimed is encoding for any betacoronavirus's spike protein.

> Here what is claimed is encoding for any betacoronavirus's spike protein.

Aha! That's what is surprising to me - I assumed that that would have been done previously / protected previously. That explains it.

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