What Ozempic does to the gut-brain axis • Hacker News Board

Re: What Ozempic does to the gut-brain axis

#321

Post by faangguyindia » Sun, Jun 28, 2026, 6:12 AM UTC

toasterlovin wrote: post #315

faangguyindia wrote: post #249

Earlier quoted context omitted.

>But this intelectual knowledge doesn't really help if your body is telling you it's hungry all the time and it's hard not to eat something. Better choices can help, because different calories deliver different satiety; but some people don't get much satiety no matter what they eat. Maybe try to figure out why you’re feeling hungry. Is it because you’re running a 1000 kcal deficit? Can your body really tell whether y…

> Maybe try to figure out why you’re feeling hungry. For a lot of people, the reason they feel hungry is because the way their brain works is that they feel better when they feel full and their life sucks for some reason, so they want to feel better . Hence overeating. It’s entirely a psychological issue for a person like this. Counting calories is not going to help them. In fact, them even being able to maintain a c…

>For a lot of people, the reason they feel hungry is because the way their brain works is that they feel better when they feel full and their life sucks for some reason

i am not trying to gain traction, i already know what i am saying applies to vast majority of people and i've yet to come across people who feel 200-300kcal deficit is impossible to apply for them because of their insane appetite.

In most cases where people say this, they are sedentary so their TDEE is very low, applying deficit makes them end up in very low calorie zone where they feel miserable.

Why all these people who are failing can't actually define their fitness journey by putting some numbers into perspective?

because they calculated nothing, they just winged it. I am not denying that there aren't people who cannot control eatingg, there are but they are rare.

Re: What Ozempic does to the gut-brain axis

#322

Post by crooked-v » Sun, Jun 28, 2026, 6:13 AM UTC

SpaceNugget wrote: post #76

saberience wrote: post #69

Earlier quoted context omitted.

[flagged]

They said exercise doesn't help them with reducing the feeling of hunger. I don't know why they thought it would, because generally if you do a lot of exercise you get more hungry not less hungry, but regardless, you are responding to something that wasn't said.

My meaning was more that indulging in that hunger would result in me just eating an exorbitant number of calories, way past anything it would be reasonable to burn off without spending 4 hours a day every day in the gym... but you're completely right that even if I did spend that time in the gym it wouldn't help with the calories-in-calories-out equation, because it would just make me more hungry.

Re: What Ozempic does to the gut-brain axis

#323

Post by grey-area » Sun, Jun 28, 2026, 6:16 AM UTC

rnewme wrote: post #234

sublinear wrote: post #221

Earlier quoted context omitted.

If you want the real answer, people suck at shopping for groceries and don't know how or want to cook. Long before LLMs, there was a different but similarly misguided hype around making food more convenient. Making money off ignorance is not "innovation", but we live in a world convinced by arrogant and pretentious fearmongering liars. As always, just do it yourself. It's not that hard after all.

Do you know what food noise is?

The latest fad promoted by companies to sell you something?

Re: What Ozempic does to the gut-brain axis

#324

Post by faangguyindia » Sun, Jun 28, 2026, 6:16 AM UTC

s1artibartfast wrote: post #319

faangguyindia wrote: post #275

Earlier quoted context omitted.

true but you'll struggle getting tons of calories out of whole foods. This is why mass gainers are popular, underweight people find it hard to gain weight so they dirty bulking using fast food which is often calorie dense. Eating healthy food alone isn't solution, you need to make your life active as well.

This has never been my problem. I can easily eat 5k calories of whole foods

What do you eat in those 5000kcal calories? Genuinely curious.

Re: What Ozempic does to the gut-brain axis

#325

Post by faangguyindia » Sun, Jun 28, 2026, 6:17 AM UTC

tsimionescu wrote: post #310

sublinear wrote: post #298

Earlier quoted context omitted.

Yes. I'm saying that it goes away when you fix your diet. Do you know what nutrients are? Deficiencies are the cause of the noise. This is an evolutionary feature, not a bug. Your body is expecting you to keep eating alternatives until you eventually stumble onto the foods that make you feel better and then keep eating those. In severe cases you might need more patience with the right foods, but if you already feel l…

It answers the question, but you are simply wrong, as anyone who has tried to lose significant weight knows from personal experience, and as countless studies have confirmed again and again.

how many of those studies are designed to fail?

Re: What Ozempic does to the gut-brain axis

#326

Post by faangguyindia » Sun, Jun 28, 2026, 6:21 AM UTC

kube-system wrote: post #318

faangguyindia wrote: post #316

Earlier quoted context omitted.

People overestimate calorie burn from exercise. For example, a lifting session may burn 200-300kcal and then they'd think they've burned a lot, so they will end up eating 500kcal back. so as a result there is no deficit there.

Exercise typically doesn’t cause people to eat because they are confused about estimating caloric expenditure, it causes them to eat by inducing hunger. Even people who track their calories perfectly often eat when hungry because it is the most basic of human instincts and our brains and bodies are wired to respond accordingly.

Higher physical activity does not always boost hunger, it can have hunger suppressing effect too.

>Even people who track their calories perfectly often eat when hungry because it is the most basic of human instincts and our brains and bodies are wired to respond accordingly.

Many people can track calories, hardly any of them are tracking calorie burn and no the ones from your watches or displayed on cardio devices aren't correct.

Many times the eating more issue you are seeing is because average guy may estimate that 1 lifting session burns 800-1000kcal. How do i know? i've asked random people in gym this question.

Re: What Ozempic does to the gut-brain axis

#327

Post by toasterlovin » Sun, Jun 28, 2026, 6:25 AM UTC

faangguyindia wrote: post #321

toasterlovin wrote: post #315

Earlier quoted context omitted.

> Maybe try to figure out why you’re feeling hungry. For a lot of people, the reason they feel hungry is because the way their brain works is that they feel better when they feel full and their life sucks for some reason, so they want to feel better . Hence overeating. It’s entirely a psychological issue for a person like this. Counting calories is not going to help them. In fact, them even being able to maintain a c…

>For a lot of people, the reason they feel hungry is because the way their brain works is that they feel better when they feel full and their life sucks for some reason i am not trying to gain traction, i already know what i am saying applies to vast majority of people and i've yet to come across people who feel 200-300kcal deficit is impossible to apply for them because of their insane appetite. In most cases where…

You’re like a guy who’s confused why drug addicts don’t just try not taking drugs.

Re: What Ozempic does to the gut-brain axis

#328

Post by kube-system » Sun, Jun 28, 2026, 6:28 AM UTC

faangguyindia wrote: post #326

kube-system wrote: post #318

Earlier quoted context omitted.

Exercise typically doesn’t cause people to eat because they are confused about estimating caloric expenditure, it causes them to eat by inducing hunger. Even people who track their calories perfectly often eat when hungry because it is the most basic of human instincts and our brains and bodies are wired to respond accordingly.

Higher physical activity does not always boost hunger, it can have hunger suppressing effect too. >Even people who track their calories perfectly often eat when hungry because it is the most basic of human instincts and our brains and bodies are wired to respond accordingly. Many people can track calories, hardly any of them are tracking calorie burn and no the ones from your watches or displayed on cardio devices ar…

Obesity also doesn’t affect everyone. But within that group, we’re typically talking about the people who do tend to have more eating triggers than people who are not obese.

It is hard to accurately calculate the calories burned in a lifting session but the ability to count calories has little to do with the causes of obesity. Even if a person could count them perfectly that doesn’t mean they are capable of manipulating the numbers to meet their goals.

Re: What Ozempic does to the gut-brain axis

#329

Post by mattlondon » Sun, Jun 28, 2026, 6:29 AM UTC

faangguyindia wrote: post #249

toast0 wrote: post #203

Earlier quoted context omitted.

Plenty of people can take this intelectual knowledge and turn it into eating behaviors that work for them. But this intelectual knowledge doesn't really help if your body is telling you it's hungry all the time and it's hard not to eat something . Better choices can help, because different calories deliver different satiety; but some people don't get much satiety no matter what they eat. Calories in vs calories out i…

>But this intelectual knowledge doesn't really help if your body is telling you it's hungry all the time and it's hard not to eat something. Better choices can help, because different calories deliver different satiety; but some people don't get much satiety no matter what they eat. Maybe try to figure out why you’re feeling hungry. Is it because you’re running a 1000 kcal deficit? Can your body really tell whether y…

> Maybe try to figure out why you’re feeling hungry. Is it because you’re running a 1000 kcal deficit?

For me I always feel hungry. Always ready to eat more. Always.

It doesn't seem to matter what I eat or how much, I have no "off switch" apart from maybe being asleep. I sit at big family meals like Christmas or thanks giving and people around me are all "man I am going to pop if I have another bite" and yet I am still reaching for more while simultaneously thinking about what is for dessert. Once I start eating for the day, that's it game over I am going to be thinking about when I can eat next the entire waking time. I have done calorie counting for years (with deficits of usually around 400-800, tracking macros etc making sure I get enough protein) and am fairly active (running 20-25km a week, strength sessions 1-2 times a week) but even when I am not counting calories or especially active that doesn't stop me wanting to eat the whole damn time.

Dieting or not, exercising or not, it makes no difference I am always ready and willing to eat more. I am in a constant mental state of food binge.

I usually stop eating when the food physically runs out on my plate, so portion control when making meals etc needs to be airtight. I work at a BigCo where there is unlimited free food at every turn, so just going to get a coffee is a nightmare as you can imagine as I am surrounded by things to eat. Like e.g. on a bad day I might end up having 6 or 7 bananas a day just to avoid picking up a chocolate bar or donut instead. It's nuts (..and yes there are nuts too and also too easy to just grab a handful...)

I think of it like an alcoholic. But an alcoholic can "go sober" and just cut it out and not get that first taste that leads to the spiralling binge. I've got to eat to stay alive though so every day I "fall off the wagon"

I am seriously considering the pill form now that is a thing. The refrigerated injections just seemed like they were incompatible with a normal busy life with travel etc

Re: What Ozempic does to the gut-brain axis

#330

Post by faangguyindia » Sun, Jun 28, 2026, 6:31 AM UTC

weregiraffe wrote: post #313

faangguyindia wrote: post #253

Earlier quoted context omitted.

>The unbelievably low success rate of diet and exercise programs for long-term weight reduction is widely documented and quite consistent with the earlier poster's experience. where is your data from? what protocol did they follow?

The problem is the difficulty in following any protocol.

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