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Ozempic shows anti-aging effects in trial

trial.medpath.com

321–330 of 868 posts

Re: Ozempic shows anti-aging effects in trial

#321
post #201

Earlier quoted context omitted.

> some weird injection What’s weird about it? Is insulin some weird injection? What about epinephrine?

Yes, if you don't need it because there is a natural method that starts fixing your problem in the first week (like cutting all carbs does for being fat), then injecting insulin for your easily fixable problem would also be up there with injecting weird stuff into yourself.

> if you don't need it

It seems like a lot of people need something other than "don't eat bread" though.

Re: Ozempic shows anti-aging effects in trial

#322
post #152

Earlier quoted context omitted.

"GLP-1s are beneficial for many conditions downstream of liver dysfunction and metabolic disease" is a much milder claim than "cure-all".

also in the news in the last couple months was "promising for breast cancer" and another cancer (can't remember, don't care), and depression as well as some other mental health disorder. If you would like to give me money i would be happy to do the research on what claims have been published about GLP-1 inhibitors since they became prescribed off-label. I assure you it's more than "many conditions downstream of [...]…

> I assure you it's more than "many conditions downstream of [...]", unless you want to concede that mental health like depression and dementia are related to gut bacteria, then we can be friends.

You have no way to assure that and haven't even made that assertion. Depression and dementia are absolutely related to digestion, gut bacteria (as you mentioned), metabolism, and hormones, all of which are affected by GLP-1s.

Also, if someone starts taking GLP-1's (which has a placebo effect to begin with), loses weight, exercises more, and sees improvement in their diabetes, why wouldn't they also see improvement in their depression?

Re: Ozempic shows anti-aging effects in trial

#323
post #255

Earlier quoted context omitted.

Why waste money and risk side effects for a drug that's not actually needed? Changing your habits is much easier.

Obviously it’s not much easier or the drug wouldn’t be so valuable. People make such a moral crusade of this - the drug works, people will take it. Behavior modification works in theory and fails for most in practice. Even for those that can make it work usually don’t hold out indefinitely.

I made no moral statement. Behavior modification has worked great for several formerly obese people that I know. They made permanent lifestyle changes without relying on drugs. I really don't care whether people take weight loss drugs or not but the reality is that there are cheaper and safer alternatives.

Re: Ozempic shows anti-aging effects in trial

#324
post #68
post #54

Earlier quoted context omitted.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

And not just weight loss, but the people I know on GLP-1's have also significantly cut back on alcohol. I think there are ongoing trials around GLP-1's and general addiction.

Friend of mine took it for his wedding and completely stopped gambling after having a problem with it. He says he's never been more focused in his life on being productive with work and family.

Re: Ozempic shows anti-aging effects in trial

#325
post #54

Earlier quoted context omitted.

I was kind of scared of these when Ozempic starting picking of steam for weight loss. I was worried that this would be having more negative effects. Turns out, generally speaking, if used with you doctor, these things are pretty safe, especially comparatively to some of the negatives of being overweight. And then I saw some of the stories on HN about how it's changed peoples lives for the better. And then people in m…

It's great because we had no other way to address this problem at a population level. Not any realistic ones, anyway. Like, I figured we were just never going to solve it, given the two possibilities were "radically re-engineer US culture such that moving to the US doesn't make previously-skinny people fatter" (with other countries heading the same direction as us needing to make similar moves, one supposes) or "find…

It does solve itself due to natural selection based on fertility rate effect of being obesity prone. Life finds a way.

Re: Ozempic shows anti-aging effects in trial

#326
post #298

Earlier quoted context omitted.

There's anecdotes, and there's science. Individually, there's (previously) been nothing better to suggest than "try harder (and, maybe, smarter)". Statistically it was almost useless, but it's the best we had. It's not bad advice exactly, it's just extremely unlikely to work for long-term, sustained weight loss. It also very much appears to be the case that weight gain and loss are heavily influenced by environmental…

Then what should I do :(

Get a GLP-1 under the supervision of a doctor or other licensed medial provider.

Re: Ozempic shows anti-aging effects in trial

#327

Earlier quoted context omitted.

[flagged]

Doctors don’t get paid for writing prescriptions. They don’t get kickbacks for writing prescriptions. A small subset of doctors are paid by pharmaceutical companies to run trials or provide expertise, but you can look that up since it’s publicly available information, and it’s not based on them prescribing you anything. At most a drug rep comes by and brings donuts or something to talk about their new drugs. Source w…

They get paid in lower risk deductibles. If a patient demands a drug they saw on commercials, the doctor can reduce liability by prescribing it in many cases.

Re: Ozempic shows anti-aging effects in trial

#328

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

Apologies if this sounds argumentative but I would be super curious of the cross-section of people that are pro-semaglutides and also anti-vaccine. I am fascinated by that too! (And I trust that HN will share a lot of great datapoints)

Re: Ozempic shows anti-aging effects in trial

#329

I find it fascinating how much a pretty large group of people just hate semaglutides and seemingly need to believe that it's some kind of Faustian bargain. I'm not talking about the people who are cautious or suspicious, that's more than reasonable, but it's clear that it's not cautious optimism in many.

> I'm not talking about the people who are cautious or suspicious, that's more than reasonable

Yah.. The track record for public health related items that have a really rapid uptake after release is not great.

Re: Ozempic shows anti-aging effects in trial

#330

Earlier quoted context omitted.

You can be gluttonous and still thin. I eat 2 lbs of ground beef a day, with tons of cheese on it. For breakfast I have 6-8 eggs, with cheese. I have my morning coffee with heavy whipping cream. For desert, I whip up some of the heaving whipping cream and have it with frozen berries thawed out. It drives gfs nuts but they're too anti fat to try it.

Eggs have about 60 calories each. Cooking 2lbs of ground beef could yield a little over 1500 calories (Source https://www.uhhospitals.org/health-information/health-and-we... ) A tablespoon of heavy whipping cream is 50 calories. There's nothing incompatible with what you wrote and a 2500 calorie diet. This confuses a lot of people who associate certain foods with becoming fat, or think that eating fat makes you fat.…

That’s a horrifying amount of saturated fat per day, though. This is an extreme risk for heart disease.

I keep hearing this, yet after 13 years of keto my cholesterol is still 100. Being fat is much higher-risk than eating fat.

I'm all for obese people taking Ozempic if they really need it, as well as thoroughly studying its long-term benefits and risks, but the fact that we're at the point of considering medical intervention as the population-wide solution to obesity is an abject failure of policy. Looking at our nutritional guidelines, you'd think everyone in America was an extreme athlete. All we have to do is:

1. Take something like the food pyramid, and put vegetables on the bottom, put fat/dairy/coconut and protein/meat/eggs/soy/mycelium in the next level up, put fruit in the next level up, and put starches and sugars on top. In other words: eat real food, mostly plants, without extreme high-carb macros, and treat fruits as dessert. Reverse the failed policy of demonizing saturated fat, and make this the official dietary recommendations for at least a generation.

2. Provide an incentive structure to use lower-GI ingredients in food products. For example, largely replace sugar with inulin fiber sweetened with stevia and/or monk fruit, and largely replace flour with alternatives made from blends of flax, wheat gluten, and resistant starch; no one will notice the difference. Stop letting Cheerios of all things market itself as "heart healthy", at least with its current formulation.

In this world, people would eat way more veggies because they'd grow up with parents and restaurants preparing them properly (with saturated fat and salt). Even for those who didn't, high fiber fortification of UPFs would provide a reasonable backstop. The low-fat/low-salt era's reframing of healthy food as "bland" is a crime against humanity.

For any fat people we still have after that, sure, put them all on Ozempic. It just shouldn't be the expected default that unmedicated people are fat while the medical establishment shrugs its shoulders and doubles down on half a century of empirically bad advice.

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