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GLP-1 drugs: An economic disruptor? (2024)

wildfirelabs.substack.com

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Re: GLP-1 drugs: An economic disruptor? (2024)

#321

Post by taurath »

xattt wrote: post #304
taurath wrote: post #297

Earlier quoted context omitted.

I tried, I got some results but it meant that my entire body’s digestive system felt like it stopped working. Constipation, nausea at the drop of a hat, finding I’d have to take a fast acting prescription anti nausea multiple times a day. I’m not that overweight, and I felt like my body was getting far less healthy and like I was starving myself. This is on the lowest starter dose, too! It just… yeah, it works as I’d…

Are these the same effects that folks would get if they stopped eating cold turkey? Would Zofran throughout the day help with the side effects until the body adjusted?

That was my hope, and I gave it a shot for a few months. I seem to be an outlier though!

Re: GLP-1 drugs: An economic disruptor? (2024)

#322

Post by pkaye »

blackeyeblitzar wrote: post #158
cj wrote: post #61

Earlier quoted context omitted.

Luckily during the “shortage” you can currently get GLP-1’s in vials rather than injection pens. The brand name GLP’s you can’t control the dose. But when you get it in a vial from a compounding pharmacy you can inject however much or little you want. Not looking forward to ever using the brand name version specifically for this reason

Aren’t any states like California trying to ban compounding pharmacies? It’s an unfortunate attack on individual freedom, but I am not sure if we will still have them 20 years from now.

Last week the FDA said the shortages are over so compounding will probably decline as they get sued by the companies.

https://www.barrons.com/articles/eli-lilly-zepbound-higher-d...

Re: GLP-1 drugs: An economic disruptor? (2024)

#324

Post by alostpuppy »

throwaway657656 wrote: post #255
netsharc wrote: post #78

Earlier quoted context omitted.

Wasn't there an ADHD drug that was popular for hyper-productivity, in the years where being productive was all the hype?

Not ADHD specifically, but about 12 years ago, the media was hyping Provigil as a "secret weapon" of the ultra-productive. Despite having a prescription, CVS told me that my insurance wouldn't cover it and it would cost $1500 for 30 pills. I walked away and then went back to buy it. If I could just get 30 additional minutes of billable time per day per pill it would be worth it. I took about 5 over a week and destroy…

That was a weird hype train when that happened around that one. I tried it and gained like 40 pounds.

Re: GLP-1 drugs: An economic disruptor? (2024)

#325

Post by gg82 »

throwaway657656 wrote: post #176
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

The above describes me but it is the consequence of my behaviors/habits. Being a workaholic, I learned long ago to ignore the leash that pulls me to the refrigerator. It seems by brain no longer sends me a "you need to eat" signal similar to the way free divers can become oblivious to the "you need to breath" signal. I wonder if with time, you can learn from this drug, form the helpful habits/behaviors and then stop…

Probably not. If it suppresses your hunger response, you will likely lose the ability to deal with hunger when you go off it.

Re: GLP-1 drugs: An economic disruptor? (2024)

#326

Post by homebrewer »

TeMPOraL wrote: post #138
SoftTalker wrote: post #67

Earlier quoted context omitted.

People who don't need to be chronically medicated should not be. There are always side effects, and we don't even know for sure what the long term risks of these medications are yet. And crowing about saving $200/mo not buying food at Starbucks, well now Novo Nordisk is getting that. Toast a bagel at home for $0.50/day instead.

> People who don't need to be chronically medicated should not be. If they're like typical westerners, they already self-medicate with coffee every day, with alcohol occasionally, and a big fraction of them (though much less than couple decades ago) also treat themselves with tobacco smoke - and ironically, weight loss is one of the few benefits some people actually use to defend their smoking. Do they need all that…

That "medication" has been used for millenia and its side effects are well understood by now. Not so much with these relatively new drugs.

Re: GLP-1 drugs: An economic disruptor? (2024)

#327

Post by homebrewer »

valunord wrote: post #254
cj wrote: post #19

I started Tirzepatide 3-4 weeks ago. (Mostly as an experiment to understand the hype around GLP's... I don't have diabetes and only very slightly overweight at 20% body fat). Even at the lowest 2.5mg starter dose which you're only allowed to stay on for 1 month: - Extreme appetite suppression to the point where I've started calorie counting specifically to make sure that I'm eating enough. It's incredibly easy to for…

Thanks for experimenting with your body. I'll be sure to check back in about ten years to see how all this shakes out. Keto + intermittent fasting are my magic pill right now and have been for some years.

I'm pretty sure keto has not been extensively studied for anything but the management of epilepsy in children that do not respond to medication. So tbh this is an odd comparison.

Re: GLP-1 drugs: An economic disruptor? (2024)

#328

Post by brianbreslin »

j_timberlake wrote: post #303
maleldil wrote: post #289

Earlier quoted context omitted.

> being overweight will be a choice Not everyone can take these drugs. Some people will have severe side effects. It's very common to have nausea, vomiting, etc., and some people will experience these frequently enough that the prescribing doctor will rescind the prescription.

Those side effects are from injecting weekly doses, right? I'm curious if daily oral doses which are smaller will solve a bunch of these problems at once, while also mitigating the supply-chain problems.

The oral semaglutide (sublingual dissolving) is like 10% as effective as the injected version. But it presumably could be given in higher doses to counteract that. I'd be shocked if the manufacturers aren't working on a more effective non-injectable version.

Re: GLP-1 drugs: An economic disruptor? (2024)

#329

Post by YokoZar »

The article warns about impending future inequality:

> Imagine two employees. One can afford these medications, the other cannot. One has regulated impulses, higher energy, better focus, and lower healthcare costs. The other doesn't. In a few years, data shows the first is three times more likely to be promoted.

> Scale that across society.

I'm not sure this is a reasonable worry. Ozempic is going out of patent in less than a year's time. There will be cheap generics all over the place. Purportedly the drug has a very low unit cost and uncomplicated manufacturing process, and every potential generic manufacturer knows it'll be a huge hit. That means we should expect it to rapidly become a commodity that's quite available.

If it really does cut food, alcohol, and cigarette costs so dramatically then I suspect a decent amount of poorer people would budget for the drug even if it didn't become cheap. It's not like poor people don't buy food, alcohol, or cigarettes today -- if it's a net savings and health/life improvement, it's even more worth buying than the alternative.

Re: GLP-1 drugs: An economic disruptor? (2024)

#330

Post by jijji »

YokoZar wrote: post #329

The article warns about impending future inequality: > Imagine two employees. One can afford these medications, the other cannot. One has regulated impulses, higher energy, better focus, and lower healthcare costs. The other doesn't. In a few years, data shows the first is three times more likely to be promoted. > Scale that across society. I'm not sure this is a reasonable worry. Ozempic is going out of patent in le…

when semaglutide and tirzepatide first came out, they were being synthesized in labs across the world for pennies per milligram, as with all compounds.
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